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Correlation between serum lipids and age-related macular degeneration: a case-control study.
J Res Health Sci 2013; 13(1):98-101JR

Abstract

BACKGROUND

Age-related macular degeneration (AMD) is one of the leading causes of visual loss among people aged 65 yr and older. The pathophysiology of AMD is poorly understood. The purpose of this study was to evaluate the relationship between serum lipid concentrations and age-related macular degeneration.

METHODS

In this case-control study, total cholesterol (TCH), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglyceride (TG) of 32 patients with AMD were compared with 32 subjects without AMD that were matched for age. Data were analyzed using Independent t and Chi-Square Tests.

RESULTS

TCH, LDL, and TG serum concentrations were significantly higher in AMD patients compared with control group (P<0.001, P<0.001 and P<0.017 respectively). There was no difference in HDL concentration between two groups (P=0.781).

CONCLUSION

High level of total cholesterol, TG and LDL were associated with increased risk of AMD. Results of this study suggest further research to better understand the underlying biological mechanisms of AMD related to serum cholesterol.

Authors+Show Affiliations

Birjand Atherosclerosis and Coronary Artery Research Centre, Department of Ophthalmology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23772022

Citation

Davari, Mohammad Hossein, et al. "Correlation Between Serum Lipids and Age-related Macular Degeneration: a Case-control Study." Journal of Research in Health Sciences, vol. 13, no. 1, 2013, pp. 98-101.
Davari MH, Gheitasi H, Yaghobi G, et al. Correlation between serum lipids and age-related macular degeneration: a case-control study. J Res Health Sci. 2013;13(1):98-101.
Davari, M. H., Gheitasi, H., Yaghobi, G., & Heydari, B. (2013). Correlation between serum lipids and age-related macular degeneration: a case-control study. Journal of Research in Health Sciences, 13(1), pp. 98-101.
Davari MH, et al. Correlation Between Serum Lipids and Age-related Macular Degeneration: a Case-control Study. J Res Health Sci. 2013 May 29;13(1):98-101. PubMed PMID: 23772022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between serum lipids and age-related macular degeneration: a case-control study. AU - Davari,Mohammad Hossein, AU - Gheitasi,Hoda, AU - Yaghobi,Gholamhossein, AU - Heydari,Behrouz, Y1 - 2013/05/29/ PY - 2013/01/04/received PY - 2013/02/18/accepted PY - 2013/01/29/revised PY - 2013/6/18/entrez PY - 2012/1/1/pubmed PY - 2015/10/31/medline KW - Age-related macular degeneration KW - Cholesterol KW - Iran KW - Serum lipids KW - Triglycerides SP - 98 EP - 101 JF - Journal of research in health sciences JO - J Res Health Sci VL - 13 IS - 1 N2 - BACKGROUND: Age-related macular degeneration (AMD) is one of the leading causes of visual loss among people aged 65 yr and older. The pathophysiology of AMD is poorly understood. The purpose of this study was to evaluate the relationship between serum lipid concentrations and age-related macular degeneration. METHODS: In this case-control study, total cholesterol (TCH), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglyceride (TG) of 32 patients with AMD were compared with 32 subjects without AMD that were matched for age. Data were analyzed using Independent t and Chi-Square Tests. RESULTS: TCH, LDL, and TG serum concentrations were significantly higher in AMD patients compared with control group (P<0.001, P<0.001 and P<0.017 respectively). There was no difference in HDL concentration between two groups (P=0.781). CONCLUSION: High level of total cholesterol, TG and LDL were associated with increased risk of AMD. Results of this study suggest further research to better understand the underlying biological mechanisms of AMD related to serum cholesterol. SN - 2228-7809 UR - https://www.unboundmedicine.com/medline/citation/23772022/Correlation_between_serum_lipids_and_age_related_macular_degeneration:_a_case_control_study_ L2 - http://jrhs.umsha.ac.ir/index.php/JRHS/article/view/828/ DB - PRIME DP - Unbound Medicine ER -