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The association between uric acid and chronic kidney disease in Korean men: a 4-year follow-up study.
J Korean Med Sci. 2013 Jun; 28(6):855-60.JK

Abstract

There have been many studies between serum uric acid (UA) and chronic kidney disease (CKD). However, as far as we know, little research has been done to examine the prospective association between serum UA and development of CKD in Korean men. This prospective cohort study was performed using 18,778 men who participated in a health checkup program both on January, 2005 and on December, 2009. CKD was defined as an estimated glomerular filtration rate < 60 mL/min per 1.73 m(2). The odds ratio (OR) from binary logistic regressions for the development of CKD was determined with respect to the quintiles grouping based on serum UA. During 74,821.4 person-years of follow-up, 110 men were found to develop CKD. The OR for the development of CKD increased as the quintiles for baseline serum UA levels increased from the first to fifth quintiles (1.00 vs 1.22, 1.19, 2.59, and 3.03, respectively, p for linear trend < 0.001) after adjusting for covariates. The adjusted OR comparing those participants with hyperuricemia (≥ 7.0 mg/dL) to those with normouricemia (< 7.0 mg/dL) was 1.96 (1.28-2.99). Elevated serum UA levels were independently associated with increased likelihood for the development of CKD in Korean men (IRB number: KBC10034).

Authors+Show Affiliations

Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23772149

Citation

Ryoo, Jae-Hong, et al. "The Association Between Uric Acid and Chronic Kidney Disease in Korean Men: a 4-year Follow-up Study." Journal of Korean Medical Science, vol. 28, no. 6, 2013, pp. 855-60.
Ryoo JH, Choi JM, Oh CM, et al. The association between uric acid and chronic kidney disease in Korean men: a 4-year follow-up study. J Korean Med Sci. 2013;28(6):855-60.
Ryoo, J. H., Choi, J. M., Oh, C. M., & Kim, M. G. (2013). The association between uric acid and chronic kidney disease in Korean men: a 4-year follow-up study. Journal of Korean Medical Science, 28(6), 855-60. https://doi.org/10.3346/jkms.2013.28.6.855
Ryoo JH, et al. The Association Between Uric Acid and Chronic Kidney Disease in Korean Men: a 4-year Follow-up Study. J Korean Med Sci. 2013;28(6):855-60. PubMed PMID: 23772149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between uric acid and chronic kidney disease in Korean men: a 4-year follow-up study. AU - Ryoo,Jae-Hong, AU - Choi,Joong-Myung, AU - Oh,Chang-Mo, AU - Kim,Min-Gi, Y1 - 2013/06/03/ PY - 2012/12/16/received PY - 2013/04/06/accepted PY - 2013/6/18/entrez PY - 2013/6/19/pubmed PY - 2014/1/8/medline KW - Kidney Failure, Chronic KW - Uric Acid SP - 855 EP - 60 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 28 IS - 6 N2 - There have been many studies between serum uric acid (UA) and chronic kidney disease (CKD). However, as far as we know, little research has been done to examine the prospective association between serum UA and development of CKD in Korean men. This prospective cohort study was performed using 18,778 men who participated in a health checkup program both on January, 2005 and on December, 2009. CKD was defined as an estimated glomerular filtration rate < 60 mL/min per 1.73 m(2). The odds ratio (OR) from binary logistic regressions for the development of CKD was determined with respect to the quintiles grouping based on serum UA. During 74,821.4 person-years of follow-up, 110 men were found to develop CKD. The OR for the development of CKD increased as the quintiles for baseline serum UA levels increased from the first to fifth quintiles (1.00 vs 1.22, 1.19, 2.59, and 3.03, respectively, p for linear trend < 0.001) after adjusting for covariates. The adjusted OR comparing those participants with hyperuricemia (≥ 7.0 mg/dL) to those with normouricemia (< 7.0 mg/dL) was 1.96 (1.28-2.99). Elevated serum UA levels were independently associated with increased likelihood for the development of CKD in Korean men (IRB number: KBC10034). SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/23772149/The_association_between_uric_acid_and_chronic_kidney_disease_in_Korean_men:_a_4_year_follow_up_study_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2013.28.6.855 DB - PRIME DP - Unbound Medicine ER -