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Postprandial lipoproteins and the molecular regulation of vascular homeostasis.
Prog Lipid Res. 2013 Oct; 52(4):446-64.PL

Abstract

Blood levels of triglyceride-rich lipoproteins (TRL) increase postprandially, and a delay in their clearance results in postprandial hyperlipidemia, an important risk factor in atherosclerosis development. Atherosclerosis is a multifactorial inflammatory disease, and its initiation involves endothelial dysfunction, invasion of the artery wall by leukocytes and subsequent formation of foam cells. TRL are implicated in several of these inflammatory processes, including the formation of damaging free radicals, leukocyte activation, endothelial dysfunction and foam cell formation. Recent studies have provided insights into the mechanisms of uptake and the signal transduction pathways mediating the interactions of TRL with leukocytes and vascular cells, and how they are modified by dietary lipids. Multiple receptor and non-receptor mediated pathways function in macrophage uptake of TRL. TRL also induce expression of adhesion molecules, cyclooxygenase-2 and heme-oxygenase-1 in endothelial cells, and activate intracellular signaling pathways involving mitogen-activated protein kinases, NF-κB and Nrf2. Many of these effects are strongly influenced by dietary components carried in TRL. There is extensive evidence indicating that raised postprandial TRL levels are a risk factor for atherosclerosis, but the molecular mechanisms involved are only now becoming appreciated. Here, we review current understanding of the mechanisms by which TRL influence vascular cell function.

Authors+Show Affiliations

Department of Comparative Biomedical Sciences, The Royal Veterinary College, Royal College St., London NW1 0TU, UK. Electronic address: kbotham@rvc.ac.uk.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23774609

Citation

Botham, Kathleen M., and Caroline P D. Wheeler-Jones. "Postprandial Lipoproteins and the Molecular Regulation of Vascular Homeostasis." Progress in Lipid Research, vol. 52, no. 4, 2013, pp. 446-64.
Botham KM, Wheeler-Jones CP. Postprandial lipoproteins and the molecular regulation of vascular homeostasis. Prog Lipid Res. 2013;52(4):446-64.
Botham, K. M., & Wheeler-Jones, C. P. (2013). Postprandial lipoproteins and the molecular regulation of vascular homeostasis. Progress in Lipid Research, 52(4), 446-64. https://doi.org/10.1016/j.plipres.2013.06.001
Botham KM, Wheeler-Jones CP. Postprandial Lipoproteins and the Molecular Regulation of Vascular Homeostasis. Prog Lipid Res. 2013;52(4):446-64. PubMed PMID: 23774609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postprandial lipoproteins and the molecular regulation of vascular homeostasis. AU - Botham,Kathleen M, AU - Wheeler-Jones,Caroline P D, Y1 - 2013/06/15/ PY - 2012/07/06/received PY - 2013/06/06/revised PY - 2013/06/06/accepted PY - 2013/6/19/entrez PY - 2013/6/19/pubmed PY - 2014/6/21/medline KW - 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine KW - ABC KW - AMP kinase KW - AMPK KW - AP KW - ATP binding cassette transporter KW - Akt KW - Apo KW - C reactive protein KW - CD KW - CM KW - CMR KW - COX KW - CREB KW - CRP KW - DHA KW - EC KW - EGF KW - EPA KW - EPC KW - ERK KW - Egr KW - Endothelial cells KW - FAK KW - FFA KW - GPIHBP1 KW - HAEC KW - HDL KW - HMDM KW - HO KW - HSPG KW - HUVEC KW - ICAM KW - IFN KW - IL KW - Inflammation KW - IκB KW - JNK KW - LDL KW - LDLR KW - LOX KW - LPL KW - LPS KW - LR11 KW - LRP KW - M1 KW - M2 KW - MAPK KW - MCP KW - MEK KW - MIP KW - MMP KW - MUFA KW - Macrophages KW - Monocytes KW - Mox KW - NAD(P)H oxidase KW - NF-κB KW - NO KW - Nox KW - Nrf KW - P KW - PAI-1 KW - PAPC KW - PGE(2) KW - PKC KW - PL KW - POA KW - PPAR KW - PUFA KW - Postprandial lipemia KW - RAP KW - RLP KW - ROS KW - RXR KW - SFA KW - SR KW - TG KW - TGF KW - TLR KW - TNF KW - TRL KW - Triglyceride-rich lipoproteins KW - V KW - VCAM KW - VE cadherin KW - VEGF KW - VLDL KW - VLDLR KW - VSMC KW - activator protein KW - alternatively activated macrophages KW - apoB48R KW - apolipoprotein KW - apolipoprotein B48 receptor KW - c-Jun N-terminal kinase KW - cAMP response element binding KW - chylomicron remnants KW - chylomicrons KW - classically activated macrophages KW - cluster of differentiation KW - cyclooxygenase KW - docosahexaenoic acid KW - eNOS KW - early growth response protein KW - eicosapentaenoic acid KW - endothelial cell KW - endothelial nitric oxide synthase KW - endothelial progenitor cell KW - epidermal growth factor KW - extracellular-signal-regulated kinase KW - focal adhesion kinase KW - free fatty acid KW - glycosylphosphatidylinositol-anchored high density lipoprotein binding protein 1 KW - hemeoxygenase KW - heparan sulfate proteoglycans KW - high density lipoprotein KW - human aortic endothelial cell KW - human monocyte-derived macrophages KW - human umbilical vein endothelial cells KW - inhibitor of κB KW - intercellular adhesion molecule KW - interferon KW - interleukin KW - lectin-like oxidized low density lipoprotein receptor KW - lipopolysaccharide KW - lipoprotein lipase KW - low density lipoprotein KW - low density lipoprotein receptor KW - low density lipoprotein receptor-related protein KW - macrophage inflammatory protein KW - macrophage phenotype induced by oxidised phospholipids KW - matrix-metalloproteinase KW - mitogen activated protein kinase kinase KW - mitogen-activated kinase KW - monocyte chemoattractant protein KW - monousaturated fatty acids KW - nitric oxide KW - nuclear factor (erythroid-derived 2)-like 2 KW - nuclear factor-κB KW - ox KW - oxidized KW - peroxisome proliferator-activated receptor KW - phospholipid KW - plasminogen activator inhibitor type 1 KW - polyunsaturated fatty acids KW - pomace oil supplemented with oleanolic acid test meal KW - pomace olive oil test meal KW - prostglandin E2 KW - protein kinase B KW - protein kinase C KW - reactive oxygen species KW - receptor associated protein KW - remnant-like particles KW - retinoid X receptor KW - saturated fatty acids KW - scavenger receptor KW - sortilin-related receptor KW - toll-like receptor KW - transforming growth factor KW - triacylglycerol KW - triglyceride-rich lipoproteins KW - tumor necrosis factor KW - vascular cell adhesion molecule KW - vascular endothelial cadherin KW - vascular endothelial growth factor KW - vascular smooth muscle cells KW - very low density lipoprotein KW - very low density lipoprotein receptor KW - virgin olive oil test meal SP - 446 EP - 64 JF - Progress in lipid research JO - Prog Lipid Res VL - 52 IS - 4 N2 - Blood levels of triglyceride-rich lipoproteins (TRL) increase postprandially, and a delay in their clearance results in postprandial hyperlipidemia, an important risk factor in atherosclerosis development. Atherosclerosis is a multifactorial inflammatory disease, and its initiation involves endothelial dysfunction, invasion of the artery wall by leukocytes and subsequent formation of foam cells. TRL are implicated in several of these inflammatory processes, including the formation of damaging free radicals, leukocyte activation, endothelial dysfunction and foam cell formation. Recent studies have provided insights into the mechanisms of uptake and the signal transduction pathways mediating the interactions of TRL with leukocytes and vascular cells, and how they are modified by dietary lipids. Multiple receptor and non-receptor mediated pathways function in macrophage uptake of TRL. TRL also induce expression of adhesion molecules, cyclooxygenase-2 and heme-oxygenase-1 in endothelial cells, and activate intracellular signaling pathways involving mitogen-activated protein kinases, NF-κB and Nrf2. Many of these effects are strongly influenced by dietary components carried in TRL. There is extensive evidence indicating that raised postprandial TRL levels are a risk factor for atherosclerosis, but the molecular mechanisms involved are only now becoming appreciated. Here, we review current understanding of the mechanisms by which TRL influence vascular cell function. SN - 1873-2194 UR - https://www.unboundmedicine.com/medline/citation/23774609/Postprandial_lipoproteins_and_the_molecular_regulation_of_vascular_homeostasis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-7827(13)00041-6 DB - PRIME DP - Unbound Medicine ER -