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Dietary sources of N-nitroso compounds and bladder cancer risk: findings from the Los Angeles bladder cancer study.

Abstract

N-Nitroso compounds (NOCs) have been proposed as possible bladder carcinogens. The main sources of exogenous exposure to NOCs are cigarette smoke and diet, particularly processed (i.e., nitrite-treated) meats. Perhaps more importantly, NOCs can be formed endogenously from dietary precursors such as nitrate, nitrite and amines. Heme has been shown to increase endogenous nitrosation. We examined the role of dietary sources of NOCs and NOC precursors as potential bladder cancer risk factors using data from the Los Angeles Bladder Cancer Study, a population-based case-control study. Dietary and demographic information was collected from 1,660 bladder cancer cases and 1,586 controls via a structured questionnaire. Intake of liver and of salami/pastrami/corned beef, were both statistically significantly associated with risk of bladder cancer in this study, particularly among nonsmokers. Heme intake was also statistically significantly associated with risk of bladder cancer among nonsmokers only. When considering NOC precursors, risk was consistently higher among subjects with concurrent high intake of nitrate and high intake of the different meats (sources of amines and nitrosamines). Results of this study are consistent with a role of dietary sources of NOC precursors from processed meats in bladder cancer risk, suggesting consumption of meats with high amine and heme content such as salami and liver as a risk factor for bladder cancer. In addition, any effect of consuming these meats may be greater when accompanied by high nitrate intake.

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  • Authors+Show Affiliations

    ,

    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA.

    , , , , ,

    Source

    International journal of cancer 134:1 2014 Jan 01 pg 125-35

    MeSH

    Adult
    Animals
    Carcinogens
    Carcinoma, Transitional Cell
    Case-Control Studies
    Cattle
    Diet
    Female
    Humans
    Los Angeles
    Male
    Meat Products
    Middle Aged
    Nitroso Compounds
    Risk Factors
    Surveys and Questionnaires
    Urinary Bladder Neoplasms

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23775870

    Citation

    Catsburg, Chelsea E., et al. "Dietary Sources of N-nitroso Compounds and Bladder Cancer Risk: Findings From the Los Angeles Bladder Cancer Study." International Journal of Cancer, vol. 134, no. 1, 2014, pp. 125-35.
    Catsburg CE, Gago-Dominguez M, Yuan JM, et al. Dietary sources of N-nitroso compounds and bladder cancer risk: findings from the Los Angeles bladder cancer study. Int J Cancer. 2014;134(1):125-35.
    Catsburg, C. E., Gago-Dominguez, M., Yuan, J. M., Castelao, J. E., Cortessis, V. K., Pike, M. C., & Stern, M. C. (2014). Dietary sources of N-nitroso compounds and bladder cancer risk: findings from the Los Angeles bladder cancer study. International Journal of Cancer, 134(1), pp. 125-35. doi:10.1002/ijc.28331.
    Catsburg CE, et al. Dietary Sources of N-nitroso Compounds and Bladder Cancer Risk: Findings From the Los Angeles Bladder Cancer Study. Int J Cancer. 2014 Jan 1;134(1):125-35. PubMed PMID: 23775870.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary sources of N-nitroso compounds and bladder cancer risk: findings from the Los Angeles bladder cancer study. AU - Catsburg,Chelsea E, AU - Gago-Dominguez,Manuela, AU - Yuan,Jian-Min, AU - Castelao,J Esteban, AU - Cortessis,Victoria K, AU - Pike,Malcolm C, AU - Stern,Mariana C, Y1 - 2013/07/15/ PY - 2012/11/26/received PY - 2013/05/22/accepted PY - 2013/6/19/entrez PY - 2013/6/19/pubmed PY - 2013/12/16/medline KW - N-nitroso compounds KW - bladder cancer KW - nitrosamines KW - processed meats SP - 125 EP - 35 JF - International journal of cancer JO - Int. J. Cancer VL - 134 IS - 1 N2 - N-Nitroso compounds (NOCs) have been proposed as possible bladder carcinogens. The main sources of exogenous exposure to NOCs are cigarette smoke and diet, particularly processed (i.e., nitrite-treated) meats. Perhaps more importantly, NOCs can be formed endogenously from dietary precursors such as nitrate, nitrite and amines. Heme has been shown to increase endogenous nitrosation. We examined the role of dietary sources of NOCs and NOC precursors as potential bladder cancer risk factors using data from the Los Angeles Bladder Cancer Study, a population-based case-control study. Dietary and demographic information was collected from 1,660 bladder cancer cases and 1,586 controls via a structured questionnaire. Intake of liver and of salami/pastrami/corned beef, were both statistically significantly associated with risk of bladder cancer in this study, particularly among nonsmokers. Heme intake was also statistically significantly associated with risk of bladder cancer among nonsmokers only. When considering NOC precursors, risk was consistently higher among subjects with concurrent high intake of nitrate and high intake of the different meats (sources of amines and nitrosamines). Results of this study are consistent with a role of dietary sources of NOC precursors from processed meats in bladder cancer risk, suggesting consumption of meats with high amine and heme content such as salami and liver as a risk factor for bladder cancer. In addition, any effect of consuming these meats may be greater when accompanied by high nitrate intake. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/23775870/Dietary_sources_of_N_nitroso_compounds_and_bladder_cancer_risk:_findings_from_the_Los_Angeles_bladder_cancer_study_ L2 - https://doi.org/10.1002/ijc.28331 DB - PRIME DP - Unbound Medicine ER -