Tags

Type your tag names separated by a space and hit enter

No association of coffee consumption with gastric ulcer, duodenal ulcer, reflux esophagitis, and non-erosive reflux disease: a cross-sectional study of 8,013 healthy subjects in Japan.

Abstract

Probably due to caffeine-induced gastric acid secretion, negative effects of coffee upon various upper-gastrointestinal diseases have been precariously accepted, despite the inadequate epidemiological evidence. Our aim is to evaluate the effect of coffee consumption on four major acid-related diseases: gastric ulcer (GU), duodenal ulcer (DU), reflux esophagitis (RE), and non-erosive reflux disease (NERD) based on the large-scale multivariate analysis. Of the 9,517 healthy adults, GU, DU, and RE were diagnosed by endoscopy, and NERD was diagnosed by the symptoms of heartburn and regurgitation without esophageal erosion. Associations between coffee consumption and the four disorders were evaluated, together with age, gender, body mass index (BMI), Helicobacter pylori (HP) infection status, pepsinogen I/II ratio, smoking, and alcohol. We further performed meta-analysis using the random effects model to redefine the relationship between coffee intake and peptic ulcer disease. The eligible 8,013 study subjects comprised of 5,451 coffee drinkers and 2,562 non-coffee drinkers. By univariate analysis, age, BMI, pepsinogen I/II ratio, smoking, and alcohol showed significant associations with coffee consumption. By multiple logistic regression analysis, positively correlated factors with significance were HP infection, current smoking, BMI, and pepsinogen I/II ratio for GU; HP infection, pepsinogen I/II ratio, and current smoking for DU; HP non-infection, male, BMI, pepsinogen I/II ratio, smoking, age, and alcohol for RE; younger age, smoking, and female for NERD. The meta-analyses could detect any association of coffee consumption with neither GU nor DU. In conclusion, there are no significant relationship between coffee consumption and the four major acid-related upper gastrointestinal disorders.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Kameda Medical Center Makuhari, Chiba, Japan.

    , , , , , ,

    Source

    PloS one 8:6 2013 pg e65996

    MeSH

    Adult
    Age Factors
    Alcohol Drinking
    Body Mass Index
    Coffee
    Cross-Sectional Studies
    Duodenal Ulcer
    Endoscopy
    Esophagitis, Peptic
    Female
    Helicobacter Infections
    Humans
    Japan
    Male
    Pepsinogen A
    Pepsinogen C
    Risk Factors
    Sex Factors
    Smoking
    Stomach Ulcer

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23776588

    Citation

    Shimamoto, Takeshi, et al. "No Association of Coffee Consumption With Gastric Ulcer, Duodenal Ulcer, Reflux Esophagitis, and Non-erosive Reflux Disease: a Cross-sectional Study of 8,013 Healthy Subjects in Japan." PloS One, vol. 8, no. 6, 2013, pp. e65996.
    Shimamoto T, Yamamichi N, Kodashima S, et al. No association of coffee consumption with gastric ulcer, duodenal ulcer, reflux esophagitis, and non-erosive reflux disease: a cross-sectional study of 8,013 healthy subjects in Japan. PLoS ONE. 2013;8(6):e65996.
    Shimamoto, T., Yamamichi, N., Kodashima, S., Takahashi, Y., Fujishiro, M., Oka, M., ... Koike, K. (2013). No association of coffee consumption with gastric ulcer, duodenal ulcer, reflux esophagitis, and non-erosive reflux disease: a cross-sectional study of 8,013 healthy subjects in Japan. PloS One, 8(6), pp. e65996. doi:10.1371/journal.pone.0065996.
    Shimamoto T, et al. No Association of Coffee Consumption With Gastric Ulcer, Duodenal Ulcer, Reflux Esophagitis, and Non-erosive Reflux Disease: a Cross-sectional Study of 8,013 Healthy Subjects in Japan. PLoS ONE. 2013;8(6):e65996. PubMed PMID: 23776588.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - No association of coffee consumption with gastric ulcer, duodenal ulcer, reflux esophagitis, and non-erosive reflux disease: a cross-sectional study of 8,013 healthy subjects in Japan. AU - Shimamoto,Takeshi, AU - Yamamichi,Nobutake, AU - Kodashima,Shinya, AU - Takahashi,Yu, AU - Fujishiro,Mitsuhiro, AU - Oka,Masashi, AU - Mitsushima,Toru, AU - Koike,Kazuhiko, Y1 - 2013/06/12/ PY - 2013/03/03/received PY - 2013/04/30/accepted PY - 2013/6/19/entrez PY - 2013/6/19/pubmed PY - 2014/1/24/medline SP - e65996 EP - e65996 JF - PloS one JO - PLoS ONE VL - 8 IS - 6 N2 - Probably due to caffeine-induced gastric acid secretion, negative effects of coffee upon various upper-gastrointestinal diseases have been precariously accepted, despite the inadequate epidemiological evidence. Our aim is to evaluate the effect of coffee consumption on four major acid-related diseases: gastric ulcer (GU), duodenal ulcer (DU), reflux esophagitis (RE), and non-erosive reflux disease (NERD) based on the large-scale multivariate analysis. Of the 9,517 healthy adults, GU, DU, and RE were diagnosed by endoscopy, and NERD was diagnosed by the symptoms of heartburn and regurgitation without esophageal erosion. Associations between coffee consumption and the four disorders were evaluated, together with age, gender, body mass index (BMI), Helicobacter pylori (HP) infection status, pepsinogen I/II ratio, smoking, and alcohol. We further performed meta-analysis using the random effects model to redefine the relationship between coffee intake and peptic ulcer disease. The eligible 8,013 study subjects comprised of 5,451 coffee drinkers and 2,562 non-coffee drinkers. By univariate analysis, age, BMI, pepsinogen I/II ratio, smoking, and alcohol showed significant associations with coffee consumption. By multiple logistic regression analysis, positively correlated factors with significance were HP infection, current smoking, BMI, and pepsinogen I/II ratio for GU; HP infection, pepsinogen I/II ratio, and current smoking for DU; HP non-infection, male, BMI, pepsinogen I/II ratio, smoking, age, and alcohol for RE; younger age, smoking, and female for NERD. The meta-analyses could detect any association of coffee consumption with neither GU nor DU. In conclusion, there are no significant relationship between coffee consumption and the four major acid-related upper gastrointestinal disorders. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23776588/full_citation L2 - http://dx.plos.org/10.1371/journal.pone.0065996 DB - PRIME DP - Unbound Medicine ER -