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Effect of omega-3 fatty acids for indicated prevention of young patients at risk for psychosis: when do they begin to be effective?
Schizophr Res. 2013 Aug; 148(1-3):163-7.SR

Abstract

The results of a recent double-blind, randomized, placebo-controlled trial performed in 81 young patients at ultra-high risk for psychosis indicated that a 12-week intervention of 1.2g/day of ω-3 polyunsaturated fatty acids (PUFA) significantly reduced the risk of transition to psychosis and improved positive, negative and general symptoms as well as functioning. The aim of this post-hoc analysis was to determine at which time point ω-3 PUFAs start to significantly differ from placebo in improving psychopathology and functioning in young people at risk of developing psychosis. Analyses were performed using the mixed model repeated-measures analysis of variance. Compared to placebo, ω-3 PUFAs' significant effects on the amplitude of the reduction in General and Total PANSS scores are evident after the first four weeks of treatment; a reduction of positive symptoms and a lower mean PANSS positive score were apparent after eight weeks, whereas the significant drop in negative symptoms and the significant change and higher mean scores in global functioning occur later at 12weeks. The delay of onset of ω -3 PUFAs seems comparable to that of antipsychotics and antidepressants.

Authors+Show Affiliations

Department of Child and Adolescent Psychiatry, Medical University Vienna, Waehringer Guertel 18-10, 1090 Vienna, Austria. nilufar.mossaheb@meduniwien.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23778032

Citation

Mossaheb, Nilufar, et al. "Effect of Omega-3 Fatty Acids for Indicated Prevention of Young Patients at Risk for Psychosis: when Do They Begin to Be Effective?" Schizophrenia Research, vol. 148, no. 1-3, 2013, pp. 163-7.
Mossaheb N, Schäfer MR, Schlögelhofer M, et al. Effect of omega-3 fatty acids for indicated prevention of young patients at risk for psychosis: when do they begin to be effective? Schizophr Res. 2013;148(1-3):163-7.
Mossaheb, N., Schäfer, M. R., Schlögelhofer, M., Klier, C. M., Cotton, S. M., McGorry, P. D., & Amminger, G. P. (2013). Effect of omega-3 fatty acids for indicated prevention of young patients at risk for psychosis: when do they begin to be effective? Schizophrenia Research, 148(1-3), 163-7. https://doi.org/10.1016/j.schres.2013.05.027
Mossaheb N, et al. Effect of Omega-3 Fatty Acids for Indicated Prevention of Young Patients at Risk for Psychosis: when Do They Begin to Be Effective. Schizophr Res. 2013;148(1-3):163-7. PubMed PMID: 23778032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of omega-3 fatty acids for indicated prevention of young patients at risk for psychosis: when do they begin to be effective? AU - Mossaheb,Nilufar, AU - Schäfer,Miriam R, AU - Schlögelhofer,Monika, AU - Klier,Claudia M, AU - Cotton,Susan M, AU - McGorry,Patrick D, AU - Amminger,G Paul, Y1 - 2013/06/15/ PY - 2012/11/22/received PY - 2013/04/30/revised PY - 2013/05/23/accepted PY - 2013/6/20/entrez PY - 2013/6/20/pubmed PY - 2014/3/13/medline KW - High risk KW - Omega-3 fatty acids KW - Prodrome KW - Psychosis KW - UHR SP - 163 EP - 7 JF - Schizophrenia research JO - Schizophr Res VL - 148 IS - 1-3 N2 - The results of a recent double-blind, randomized, placebo-controlled trial performed in 81 young patients at ultra-high risk for psychosis indicated that a 12-week intervention of 1.2g/day of ω-3 polyunsaturated fatty acids (PUFA) significantly reduced the risk of transition to psychosis and improved positive, negative and general symptoms as well as functioning. The aim of this post-hoc analysis was to determine at which time point ω-3 PUFAs start to significantly differ from placebo in improving psychopathology and functioning in young people at risk of developing psychosis. Analyses were performed using the mixed model repeated-measures analysis of variance. Compared to placebo, ω-3 PUFAs' significant effects on the amplitude of the reduction in General and Total PANSS scores are evident after the first four weeks of treatment; a reduction of positive symptoms and a lower mean PANSS positive score were apparent after eight weeks, whereas the significant drop in negative symptoms and the significant change and higher mean scores in global functioning occur later at 12weeks. The delay of onset of ω -3 PUFAs seems comparable to that of antipsychotics and antidepressants. SN - 1573-2509 UR - https://www.unboundmedicine.com/medline/citation/23778032/Effect_of_omega_3_fatty_acids_for_indicated_prevention_of_young_patients_at_risk_for_psychosis:_when_do_they_begin_to_be_effective L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(13)00282-X DB - PRIME DP - Unbound Medicine ER -