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Maternal vitamin D status and risk of pre-eclampsia: a systematic review and meta-analysis.
J Clin Endocrinol Metab 2013; 98(8):3165-73JC

Abstract

BACKGROUND

Although several studies have investigated the association between maternal serum vitamin D levels and risk of pre-eclampsia, findings are inconsistent. This systematic review and meta-analysis of published observational studies was conducted to summarize the evidence on the association between maternal serum vitamin D levels and risk of pre-eclampsia.

METHODS

PubMed, ISI (Web of science), SCOPUS, SCIRUS, Google Scholar, and EMBASE databases were searched to identify related articles published through December 2012. For systematic review, we found 15 articles that assessed the association between maternal serum vitamin D levels and risk of pre-eclampsia. The meta-analysis was done on 8 studies that reported odds ratios or relative risks for pre-eclampsia. Between-study heterogeneity was examined using Cochran's Q test and I(2). Subgroup analysis and meta-regression were used to find possible sources of heterogeneity.

RESULTS

The meta-analysis on 8 relevant papers revealed an overall significant association between vitamin D deficiency and risk of pre-eclampsia; however, there was significant between-study heterogeneity (I(2) = 52.7%; P = .039). In the subgroup analysis, we found that the overall effect was significant for studies that defined vitamin D deficiency as 25(OH)D ≤ 50 nmol/L (20 ng/mL), but not for those that considered it as <38 nmol/L (15.2 ng/mL). The association was seen for "cohort or nested case-control studies" as well as for "cross-sectional or case-control studies" (2.78; 1.45-5.33; P = .002). When the analysis was done by study location, the associations remained significant only for studies that came from the United States.

CONCLUSION

There was a significant relationship between vitamin D deficiency and increased risk of pre-eclampsia. Further studies are required, particularly in developing countries.

Authors+Show Affiliations

Food Security Research Center, Isfahan University of Medical Sciences, Isfahan 81745-151, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

23783101

Citation

Tabesh, Marjan, et al. "Maternal Vitamin D Status and Risk of Pre-eclampsia: a Systematic Review and Meta-analysis." The Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 8, 2013, pp. 3165-73.
Tabesh M, Salehi-Abargouei A, Tabesh M, et al. Maternal vitamin D status and risk of pre-eclampsia: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2013;98(8):3165-73.
Tabesh, M., Salehi-Abargouei, A., Tabesh, M., & Esmaillzadeh, A. (2013). Maternal vitamin D status and risk of pre-eclampsia: a systematic review and meta-analysis. The Journal of Clinical Endocrinology and Metabolism, 98(8), pp. 3165-73. doi:10.1210/jc.2013-1257.
Tabesh M, et al. Maternal Vitamin D Status and Risk of Pre-eclampsia: a Systematic Review and Meta-analysis. J Clin Endocrinol Metab. 2013;98(8):3165-73. PubMed PMID: 23783101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal vitamin D status and risk of pre-eclampsia: a systematic review and meta-analysis. AU - Tabesh,Marjan, AU - Salehi-Abargouei,Amin, AU - Tabesh,Maryam, AU - Esmaillzadeh,Ahmad, Y1 - 2013/06/19/ PY - 2013/6/21/entrez PY - 2013/6/21/pubmed PY - 2013/11/5/medline SP - 3165 EP - 73 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 98 IS - 8 N2 - BACKGROUND: Although several studies have investigated the association between maternal serum vitamin D levels and risk of pre-eclampsia, findings are inconsistent. This systematic review and meta-analysis of published observational studies was conducted to summarize the evidence on the association between maternal serum vitamin D levels and risk of pre-eclampsia. METHODS: PubMed, ISI (Web of science), SCOPUS, SCIRUS, Google Scholar, and EMBASE databases were searched to identify related articles published through December 2012. For systematic review, we found 15 articles that assessed the association between maternal serum vitamin D levels and risk of pre-eclampsia. The meta-analysis was done on 8 studies that reported odds ratios or relative risks for pre-eclampsia. Between-study heterogeneity was examined using Cochran's Q test and I(2). Subgroup analysis and meta-regression were used to find possible sources of heterogeneity. RESULTS: The meta-analysis on 8 relevant papers revealed an overall significant association between vitamin D deficiency and risk of pre-eclampsia; however, there was significant between-study heterogeneity (I(2) = 52.7%; P = .039). In the subgroup analysis, we found that the overall effect was significant for studies that defined vitamin D deficiency as 25(OH)D ≤ 50 nmol/L (20 ng/mL), but not for those that considered it as <38 nmol/L (15.2 ng/mL). The association was seen for "cohort or nested case-control studies" as well as for "cross-sectional or case-control studies" (2.78; 1.45-5.33; P = .002). When the analysis was done by study location, the associations remained significant only for studies that came from the United States. CONCLUSION: There was a significant relationship between vitamin D deficiency and increased risk of pre-eclampsia. Further studies are required, particularly in developing countries. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/23783101/Maternal_vitamin_D_status_and_risk_of_pre_eclampsia:_a_systematic_review_and_meta_analysis_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2013-1257 DB - PRIME DP - Unbound Medicine ER -