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Risk factors and outcomes of maternal obesity and excessive weight gain during pregnancy.
Obesity (Silver Spring) 2013; 21(5):1046-55O

Abstract

OBJECTIVE

The prevalence of overweight and obesity among women of reproductive age is increasing. We aimed to determine risk factors and maternal, fetal and childhood consequences of maternal obesity and excessive gestational weight gain.

DESIGN AND METHODS

The study was embedded in a population-based prospective cohort study among 6959 mothers and their children. The study was based in Rotterdam, The Netherlands (2001-2005).

RESULTS

Maternal lower educational level, lower household income, multiparity, and FTO risk allel were associated with an increased risk of maternal obesity, whereas maternal European ethnicity, nulliparity, higher total energy intake, and smoking during pregnancy were associated with an increased risk of excessive gestational weight gain (all p-values <0.05). As compared to normal weight, maternal obesity was associated with increased risks of gestational hypertension (OR 6.31 (95% CI 4.30, 9.26)), preeclampsia (OR (3.61, (95% CI 2.04, 6.39)), gestational diabetes (OR 6.28 (95%CI 3.01, 13.06)), caesarean delivery (OR 1.91 (95% CI 1.46, 2.50)), delivering large size for gestational age infants (OR 2.97 (95% CI 2.16, 4.08)), and childhood obesity (OR 5.02 (95% CI:2.97, 8.45)). Weaker associations of excessive gestational weight gain with maternal, fetal and childhood outcomes were observed, with the strongest effects for first trimester weight gain.

CONCLUSIONS

Our study shows that maternal obesity and excessive weight gain during pregnancy are associated with socio-demographic, lifestyle, and genetic factors and with increased risks of adverse maternal, fetal and childhood outcomes. As compared to prepregnancy overweight and obesity, excessive gestational weight gain has a limited influence on adverse pregnancy outcomes.

Authors+Show Affiliations

Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23784909

Citation

Gaillard, Romy, et al. "Risk Factors and Outcomes of Maternal Obesity and Excessive Weight Gain During Pregnancy." Obesity (Silver Spring, Md.), vol. 21, no. 5, 2013, pp. 1046-55.
Gaillard R, Durmuş B, Hofman A, et al. Risk factors and outcomes of maternal obesity and excessive weight gain during pregnancy. Obesity (Silver Spring). 2013;21(5):1046-55.
Gaillard, R., Durmuş, B., Hofman, A., Mackenbach, J. P., Steegers, E. A., & Jaddoe, V. W. (2013). Risk factors and outcomes of maternal obesity and excessive weight gain during pregnancy. Obesity (Silver Spring, Md.), 21(5), pp. 1046-55. doi:10.1002/oby.20088.
Gaillard R, et al. Risk Factors and Outcomes of Maternal Obesity and Excessive Weight Gain During Pregnancy. Obesity (Silver Spring). 2013;21(5):1046-55. PubMed PMID: 23784909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors and outcomes of maternal obesity and excessive weight gain during pregnancy. AU - Gaillard,Romy, AU - Durmuş,Büşra, AU - Hofman,Albert, AU - Mackenbach,Johan P, AU - Steegers,Eric A P, AU - Jaddoe,Vincent W V, PY - 2012/09/04/accepted PY - 2012/09/19/received PY - 2013/6/21/entrez PY - 2013/6/21/pubmed PY - 2014/1/15/medline SP - 1046 EP - 55 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 21 IS - 5 N2 - OBJECTIVE: The prevalence of overweight and obesity among women of reproductive age is increasing. We aimed to determine risk factors and maternal, fetal and childhood consequences of maternal obesity and excessive gestational weight gain. DESIGN AND METHODS: The study was embedded in a population-based prospective cohort study among 6959 mothers and their children. The study was based in Rotterdam, The Netherlands (2001-2005). RESULTS: Maternal lower educational level, lower household income, multiparity, and FTO risk allel were associated with an increased risk of maternal obesity, whereas maternal European ethnicity, nulliparity, higher total energy intake, and smoking during pregnancy were associated with an increased risk of excessive gestational weight gain (all p-values <0.05). As compared to normal weight, maternal obesity was associated with increased risks of gestational hypertension (OR 6.31 (95% CI 4.30, 9.26)), preeclampsia (OR (3.61, (95% CI 2.04, 6.39)), gestational diabetes (OR 6.28 (95%CI 3.01, 13.06)), caesarean delivery (OR 1.91 (95% CI 1.46, 2.50)), delivering large size for gestational age infants (OR 2.97 (95% CI 2.16, 4.08)), and childhood obesity (OR 5.02 (95% CI:2.97, 8.45)). Weaker associations of excessive gestational weight gain with maternal, fetal and childhood outcomes were observed, with the strongest effects for first trimester weight gain. CONCLUSIONS: Our study shows that maternal obesity and excessive weight gain during pregnancy are associated with socio-demographic, lifestyle, and genetic factors and with increased risks of adverse maternal, fetal and childhood outcomes. As compared to prepregnancy overweight and obesity, excessive gestational weight gain has a limited influence on adverse pregnancy outcomes. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/23784909/Risk_factors_and_outcomes_of_maternal_obesity_and_excessive_weight_gain_during_pregnancy_ L2 - https://doi.org/10.1002/oby.20088 DB - PRIME DP - Unbound Medicine ER -