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Sclerosing cholangitis induced by formaldehyde solution injected into the biliary tree of rats.

Abstract

Sclerosing cholangitis has been reported after surgical treatment of hydatid disease of the liver and has been hypothetically attributed to the caustic effect of the parasiticide solution injected into the cyst and diffusing into the biliary tree through a cystic-biliary fistula. In this experimental study, we showed that, in rats, injection into the biliary tract of 20% hypertonic saline solution or 2% formaldehyde solution, the most commonly used scolicidal solutions, was followed by lesions of the biliary epithelium. As compared with 20% hypertonic saline solution, the 2% formaldehyde solution caused more severe lesions of the biliary epithelium and, in addition, induced the development of sclerosis. This experimental study confirms the deleterious effect of scolicidal solutions to the biliary epithelium, shows that their effect is mainly related to the causticity of the scolicidal solution, and indicates that intracystic injection of 2% formaldehyde solution should be abandoned.

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  • Authors+Show Affiliations

    ,

    Service of Digestive Surgery, Hôpital Universitaire Tenon, Paris, France.

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    Source

    MeSH

    Animals
    Cholangitis, Sclerosing
    Common Bile Duct
    Disease Models, Animal
    Duodenum
    Echinococcosis, Hepatic
    Epithelium
    Formaldehyde
    Liver
    Rats
    Rats, Inbred Strains
    Saline Solution, Hypertonic

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    2378559

    Citation

    Houry, S, et al. "Sclerosing Cholangitis Induced By Formaldehyde Solution Injected Into the Biliary Tree of Rats." Archives of Surgery (Chicago, Ill. : 1960), vol. 125, no. 8, 1990, pp. 1059-61.
    Houry S, Languille O, Huguier M, et al. Sclerosing cholangitis induced by formaldehyde solution injected into the biliary tree of rats. Arch Surg. 1990;125(8):1059-61.
    Houry, S., Languille, O., Huguier, M., Benhamou, J. P., Belghiti, J., & Msika, S. (1990). Sclerosing cholangitis induced by formaldehyde solution injected into the biliary tree of rats. Archives of Surgery (Chicago, Ill. : 1960), 125(8), pp. 1059-61.
    Houry S, et al. Sclerosing Cholangitis Induced By Formaldehyde Solution Injected Into the Biliary Tree of Rats. Arch Surg. 1990;125(8):1059-61. PubMed PMID: 2378559.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Sclerosing cholangitis induced by formaldehyde solution injected into the biliary tree of rats. AU - Houry,S, AU - Languille,O, AU - Huguier,M, AU - Benhamou,J P, AU - Belghiti,J, AU - Msika,S, PY - 1990/8/1/pubmed PY - 1990/8/1/medline PY - 1990/8/1/entrez SP - 1059 EP - 61 JF - Archives of surgery (Chicago, Ill. : 1960) JO - Arch Surg VL - 125 IS - 8 N2 - Sclerosing cholangitis has been reported after surgical treatment of hydatid disease of the liver and has been hypothetically attributed to the caustic effect of the parasiticide solution injected into the cyst and diffusing into the biliary tree through a cystic-biliary fistula. In this experimental study, we showed that, in rats, injection into the biliary tract of 20% hypertonic saline solution or 2% formaldehyde solution, the most commonly used scolicidal solutions, was followed by lesions of the biliary epithelium. As compared with 20% hypertonic saline solution, the 2% formaldehyde solution caused more severe lesions of the biliary epithelium and, in addition, induced the development of sclerosis. This experimental study confirms the deleterious effect of scolicidal solutions to the biliary epithelium, shows that their effect is mainly related to the causticity of the scolicidal solution, and indicates that intracystic injection of 2% formaldehyde solution should be abandoned. SN - 0004-0010 UR - https://www.unboundmedicine.com/medline/citation/2378559/Sclerosing_cholangitis_induced_by_formaldehyde_solution_injected_into_the_biliary_tree_of_rats_ L2 - https://jamanetwork.com/journals/jamasurgery/fullarticle/vol/125/pg/1059 DB - PRIME DP - Unbound Medicine ER -