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TNF-α inhibition using etanercept prevents noise-induced hearing loss by improvement of cochlear blood flow in vivo.
Int J Audiol. 2013 Aug; 52(8):545-52.IJ

Abstract

OBJECTIVE

Exposure to loud noise can impair cochlear microcirculation and cause noise-induced hearing loss (NIHL). TNF-α signaling has been shown to be activated in NIHL and to control spiral modiolar artery vasoconstriction that regulates cochlear microcirculation. It was the aim of this experimental study to analyse the effects of the TNF-α inhibitor etanercept on cochlear microcirculation and hearing threshold shift in NIHL in vivo.

DESIGN

After assessment of normacusis using ABR, loud noise (106 dB SPL, 30 minutes) was applied on both ears in guinea pigs. Etanercept was administered systemically after loud noise exposure while control animals received a saline solution. In vivo fluorescence microscopy of strial capillaries was performed after surgical exposure of the cochlea for microcirculatory analysis. ABR measurements were derived from the contralateral ear.

STUDY SAMPLE

Guinea pigs (n = 6, per group).

RESULTS

Compared to controls, cochlear blood flow in strial capillary segments was significantly increased in etanercept-treated animals. Additionally, hearing threshold was preserved in animals receiving the TNF-α inhibitor in contrast to a significant threshold raising in controls.

CONCLUSIONS

TNF-α inhibition using etanercept improves cochlear microcirculation and protects hearing levels after loud noise exposure and appears as a promising treatment strategy for human NIHL.

Authors+Show Affiliations

Walter Brendel Centre of Experimental Medicine (WBex), University of Munich (LMU), Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23786392

Citation

Arpornchayanon, Warangkana, et al. "TNF-α Inhibition Using Etanercept Prevents Noise-induced Hearing Loss By Improvement of Cochlear Blood Flow in Vivo." International Journal of Audiology, vol. 52, no. 8, 2013, pp. 545-52.
Arpornchayanon W, Canis M, Ihler F, et al. TNF-α inhibition using etanercept prevents noise-induced hearing loss by improvement of cochlear blood flow in vivo. Int J Audiol. 2013;52(8):545-52.
Arpornchayanon, W., Canis, M., Ihler, F., Settevendemie, C., & Strieth, S. (2013). TNF-α inhibition using etanercept prevents noise-induced hearing loss by improvement of cochlear blood flow in vivo. International Journal of Audiology, 52(8), 545-52. https://doi.org/10.3109/14992027.2013.790564
Arpornchayanon W, et al. TNF-α Inhibition Using Etanercept Prevents Noise-induced Hearing Loss By Improvement of Cochlear Blood Flow in Vivo. Int J Audiol. 2013;52(8):545-52. PubMed PMID: 23786392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TNF-α inhibition using etanercept prevents noise-induced hearing loss by improvement of cochlear blood flow in vivo. AU - Arpornchayanon,Warangkana, AU - Canis,Martin, AU - Ihler,Friedrich, AU - Settevendemie,Claudia, AU - Strieth,Sebastian, Y1 - 2013/06/20/ PY - 2013/6/22/entrez PY - 2013/6/22/pubmed PY - 2014/2/13/medline SP - 545 EP - 52 JF - International journal of audiology JO - Int J Audiol VL - 52 IS - 8 N2 - OBJECTIVE: Exposure to loud noise can impair cochlear microcirculation and cause noise-induced hearing loss (NIHL). TNF-α signaling has been shown to be activated in NIHL and to control spiral modiolar artery vasoconstriction that regulates cochlear microcirculation. It was the aim of this experimental study to analyse the effects of the TNF-α inhibitor etanercept on cochlear microcirculation and hearing threshold shift in NIHL in vivo. DESIGN: After assessment of normacusis using ABR, loud noise (106 dB SPL, 30 minutes) was applied on both ears in guinea pigs. Etanercept was administered systemically after loud noise exposure while control animals received a saline solution. In vivo fluorescence microscopy of strial capillaries was performed after surgical exposure of the cochlea for microcirculatory analysis. ABR measurements were derived from the contralateral ear. STUDY SAMPLE: Guinea pigs (n = 6, per group). RESULTS: Compared to controls, cochlear blood flow in strial capillary segments was significantly increased in etanercept-treated animals. Additionally, hearing threshold was preserved in animals receiving the TNF-α inhibitor in contrast to a significant threshold raising in controls. CONCLUSIONS: TNF-α inhibition using etanercept improves cochlear microcirculation and protects hearing levels after loud noise exposure and appears as a promising treatment strategy for human NIHL. SN - 1708-8186 UR - https://www.unboundmedicine.com/medline/citation/23786392/TNF_α_inhibition_using_etanercept_prevents_noise_induced_hearing_loss_by_improvement_of_cochlear_blood_flow_in_vivo_ L2 - http://www.tandfonline.com/doi/full/10.3109/14992027.2013.790564 DB - PRIME DP - Unbound Medicine ER -