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The effects of child maltreatment and polymorphisms of the serotonin transporter and dopamine D4 receptor genes on infant attachment and intervention efficacy.
Dev Psychopathol. 2011 May; 23(2):357-72.DP

Abstract

This investigation examined the extent to which polymorphisms of the serotonin transporter linked promoter region (5-HTTLPR) and the dopamine receptor D4 (DRD4) genes differentially influenced the development of attachment security and disorganization in maltreated and nonmaltreated infants at age 13 months, and the extent to which the efficacy of preventive interventions to promote attachment security were influenced by genetic variation. The sample consisted of 106 infants from maltreating families, participating in a randomized control trial evaluating the efficacy of two interventions, child-parent psychotherapy and psychoeducational parenting intervention, and 47 infants from nonmaltreating families. DNA samples were genotyped for polymorphisms of 5-HTTLPR, DRD4 exon III variable number tandem repeat, and DRD4-521. Attachment organization at age 1 and at age 2 was assessed with the Strange Situation for all participants, prior to and following the completion of the interventions. High rates of disorganized attachment were observed in the maltreatment compared to the nonmaltreatment group, and both interventions resulted in increased rates of attachment security at age 2. Genetic variation did not influence improvement in attachment organization among maltreated infants. Among maltreated infants, genetic variation had minimal effect on attachment organization. In contrast, among nonmaltreated infants, 5-HTTLPR and DRD4 polymorphisms influenced attachment security and disorganization at age 2 and the stability of attachment disorganization over time.

Authors+Show Affiliations

Institute of Child Development, 51 East River Road, University of Minnesota, Minneapolis, MN 55455, USA. cicchett@umn.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23786683

Citation

Cicchetti, Dante, et al. "The Effects of Child Maltreatment and Polymorphisms of the Serotonin Transporter and Dopamine D4 Receptor Genes On Infant Attachment and Intervention Efficacy." Development and Psychopathology, vol. 23, no. 2, 2011, pp. 357-72.
Cicchetti D, Rogosch FA, Toth SL. The effects of child maltreatment and polymorphisms of the serotonin transporter and dopamine D4 receptor genes on infant attachment and intervention efficacy. Dev Psychopathol. 2011;23(2):357-72.
Cicchetti, D., Rogosch, F. A., & Toth, S. L. (2011). The effects of child maltreatment and polymorphisms of the serotonin transporter and dopamine D4 receptor genes on infant attachment and intervention efficacy. Development and Psychopathology, 23(2), 357-72. https://doi.org/10.1017/S0954579411000113
Cicchetti D, Rogosch FA, Toth SL. The Effects of Child Maltreatment and Polymorphisms of the Serotonin Transporter and Dopamine D4 Receptor Genes On Infant Attachment and Intervention Efficacy. Dev Psychopathol. 2011;23(2):357-72. PubMed PMID: 23786683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of child maltreatment and polymorphisms of the serotonin transporter and dopamine D4 receptor genes on infant attachment and intervention efficacy. AU - Cicchetti,Dante, AU - Rogosch,Fred A, AU - Toth,Sheree L, PY - 2013/6/22/entrez PY - 2011/5/1/pubmed PY - 2014/2/8/medline SP - 357 EP - 72 JF - Development and psychopathology JO - Dev. Psychopathol. VL - 23 IS - 2 N2 - This investigation examined the extent to which polymorphisms of the serotonin transporter linked promoter region (5-HTTLPR) and the dopamine receptor D4 (DRD4) genes differentially influenced the development of attachment security and disorganization in maltreated and nonmaltreated infants at age 13 months, and the extent to which the efficacy of preventive interventions to promote attachment security were influenced by genetic variation. The sample consisted of 106 infants from maltreating families, participating in a randomized control trial evaluating the efficacy of two interventions, child-parent psychotherapy and psychoeducational parenting intervention, and 47 infants from nonmaltreating families. DNA samples were genotyped for polymorphisms of 5-HTTLPR, DRD4 exon III variable number tandem repeat, and DRD4-521. Attachment organization at age 1 and at age 2 was assessed with the Strange Situation for all participants, prior to and following the completion of the interventions. High rates of disorganized attachment were observed in the maltreatment compared to the nonmaltreatment group, and both interventions resulted in increased rates of attachment security at age 2. Genetic variation did not influence improvement in attachment organization among maltreated infants. Among maltreated infants, genetic variation had minimal effect on attachment organization. In contrast, among nonmaltreated infants, 5-HTTLPR and DRD4 polymorphisms influenced attachment security and disorganization at age 2 and the stability of attachment disorganization over time. SN - 1469-2198 UR - https://www.unboundmedicine.com/medline/citation/23786683/The_effects_of_child_maltreatment_and_polymorphisms_of_the_serotonin_transporter_and_dopamine_D4_receptor_genes_on_infant_attachment_and_intervention_efficacy_ L2 - https://www.cambridge.org/core/product/identifier/S0954579411000113/type/journal_article DB - PRIME DP - Unbound Medicine ER -