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Significant association of hematinic deficiencies and high blood homocysteine levels with burning mouth syndrome.
J Formos Med Assoc. 2013 Jun; 112(6):319-25.JF

Abstract

BACKGROUND/PURPOSE

Burning mouth syndrome (BMS) is characterized by a burning sensation of the oral mucosa in the absence of clinically apparent mucosal alterations. In this study, we evaluated whether there was an intimate association of the deficiency of hemoglobin (Hb), iron, vitamin B12, or folic acid; high blood homocysteine level; and serum gastric parietal cell antibody (GPCA) positivity with BMS.

METHODS

Blood Hb, iron, vitamin B12, folic acid, and homocysteine concentrations and the serum GPCA level were measured in 399 BMS patients and compared with the corresponding levels in 399 age- and sex-matched healthy control individuals.

RESULTS

We found that 89 (22.3%), 81 (20.3%), 10 (2.5%), and six (1.5%) BMS patients had deficiencies of Hb (men: <13 g/dL, women: <12 g/dL), iron (<60 μg/dL), vitamin B12 (<200 pg/mL), and folic acid (<4 ng/mL), respectively. Moreover, 89 (22.3%) BMS patients had abnormally high blood homocysteine level and 53 (13.3%) had serum GPCA positivity. BMS patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency; of abnormally elevated blood homocysteine level; or of serum GPCA positivity than the healthy control group (all p < 0.001 except for vitamin B12 deficiency, for which p = 0.004). However, no significant difference in frequency of folic acid deficiency (p = 0.129) was found between BMS patients and healthy control individuals.

CONCLUSION

We conclude that there is a significant association of deficiency of Hb, iron, and vitamin B12; abnormally high blood homocysteine level; and serum GPCA positivity with BMS.

Authors+Show Affiliations

Graduate Institute of Clinical Dentistry, National Taiwan University, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23787008

Citation

Lin, Hung-Pin, et al. "Significant Association of Hematinic Deficiencies and High Blood Homocysteine Levels With Burning Mouth Syndrome." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 112, no. 6, 2013, pp. 319-25.
Lin HP, Wang YP, Chen HM, et al. Significant association of hematinic deficiencies and high blood homocysteine levels with burning mouth syndrome. J Formos Med Assoc. 2013;112(6):319-25.
Lin, H. P., Wang, Y. P., Chen, H. M., Kuo, Y. S., Lang, M. J., & Sun, A. (2013). Significant association of hematinic deficiencies and high blood homocysteine levels with burning mouth syndrome. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 112(6), 319-25. https://doi.org/10.1016/j.jfma.2012.02.022
Lin HP, et al. Significant Association of Hematinic Deficiencies and High Blood Homocysteine Levels With Burning Mouth Syndrome. J Formos Med Assoc. 2013;112(6):319-25. PubMed PMID: 23787008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significant association of hematinic deficiencies and high blood homocysteine levels with burning mouth syndrome. AU - Lin,Hung-Pin, AU - Wang,Yi-Ping, AU - Chen,Hsin-Ming, AU - Kuo,Ying-Shiung, AU - Lang,Ming-Jane, AU - Sun,Andy, Y1 - 2012/06/12/ PY - 2012/01/19/received PY - 2012/02/13/revised PY - 2012/02/17/accepted PY - 2013/6/22/entrez PY - 2013/6/22/pubmed PY - 2014/1/31/medline SP - 319 EP - 25 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 112 IS - 6 N2 - BACKGROUND/PURPOSE: Burning mouth syndrome (BMS) is characterized by a burning sensation of the oral mucosa in the absence of clinically apparent mucosal alterations. In this study, we evaluated whether there was an intimate association of the deficiency of hemoglobin (Hb), iron, vitamin B12, or folic acid; high blood homocysteine level; and serum gastric parietal cell antibody (GPCA) positivity with BMS. METHODS: Blood Hb, iron, vitamin B12, folic acid, and homocysteine concentrations and the serum GPCA level were measured in 399 BMS patients and compared with the corresponding levels in 399 age- and sex-matched healthy control individuals. RESULTS: We found that 89 (22.3%), 81 (20.3%), 10 (2.5%), and six (1.5%) BMS patients had deficiencies of Hb (men: <13 g/dL, women: <12 g/dL), iron (<60 μg/dL), vitamin B12 (<200 pg/mL), and folic acid (<4 ng/mL), respectively. Moreover, 89 (22.3%) BMS patients had abnormally high blood homocysteine level and 53 (13.3%) had serum GPCA positivity. BMS patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency; of abnormally elevated blood homocysteine level; or of serum GPCA positivity than the healthy control group (all p < 0.001 except for vitamin B12 deficiency, for which p = 0.004). However, no significant difference in frequency of folic acid deficiency (p = 0.129) was found between BMS patients and healthy control individuals. CONCLUSION: We conclude that there is a significant association of deficiency of Hb, iron, and vitamin B12; abnormally high blood homocysteine level; and serum GPCA positivity with BMS. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/23787008/Significant_association_of_hematinic_deficiencies_and_high_blood_homocysteine_levels_with_burning_mouth_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(12)00188-X DB - PRIME DP - Unbound Medicine ER -