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Traditional Chinese medicine network pharmacology: theory, methodology and application.
Chin J Nat Med 2013; 11(2):110-20CJ

Abstract

Traditional Chinese medicine (TCM) has a long history of viewing an individual or patient as a system with different statuses, and has accumulated numerous herbal formulae. The holistic philosophy of TCM shares much with the key ideas of emerging network pharmacology and network biology, and meets the requirements of overcoming complex diseases, such as cancer, in a systematic manner. To discover TCM from a systems perspective and at the molecular level, a novel TCM network pharmacology approach was established by updating the research paradigm from the current "one target, one drug" mode to a new "network target, multi-components" mode. Subsequently, a set of TCM network pharmacology methods were created to prioritize disease-associated genes, to predict the target profiles and pharmacological actions of herbal compounds, to reveal drug-gene-disease co-module associations, to screen synergistic multi-compounds from herbal formulae in a high-throughput manner, and to interpret the combinatorial rules and network regulation effects of herbal formulae. The effectiveness of the network-based methods was demonstrated for the discovery of bioactive compounds and for the elucidation of the mechanisms of action of herbal formulae, such as Qing-Luo-Yin and the Liu-Wei-Di-Huang pill. The studies suggest that the TCM network pharmacology approach provides a new research paradigm for translating TCM from an experience-based medicine to an evidence-based medicine system, which will accelerate TCM drug discovery, and also improve current drug discovery strategies.

Authors+Show Affiliations

Bioinformatics Division and Center for Synthetic and Systems Biology, TNLIST/Department of Automation, Tsinghua University, Beijing 100084, China. shaoli@mail.tsinghua.edu.cnNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23787177

Citation

Li, Shao, and Bo Zhang. "Traditional Chinese Medicine Network Pharmacology: Theory, Methodology and Application." Chinese Journal of Natural Medicines, vol. 11, no. 2, 2013, pp. 110-20.
Li S, Zhang B. Traditional Chinese medicine network pharmacology: theory, methodology and application. Chin J Nat Med. 2013;11(2):110-20.
Li, S., & Zhang, B. (2013). Traditional Chinese medicine network pharmacology: theory, methodology and application. Chinese Journal of Natural Medicines, 11(2), pp. 110-20. doi:10.1016/S1875-5364(13)60037-0.
Li S, Zhang B. Traditional Chinese Medicine Network Pharmacology: Theory, Methodology and Application. Chin J Nat Med. 2013;11(2):110-20. PubMed PMID: 23787177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Traditional Chinese medicine network pharmacology: theory, methodology and application. AU - Li,Shao, AU - Zhang,Bo, PY - 2013/02/12/received PY - 2013/6/22/entrez PY - 2013/6/22/pubmed PY - 2014/1/5/medline SP - 110 EP - 20 JF - Chinese journal of natural medicines JO - Chin J Nat Med VL - 11 IS - 2 N2 - Traditional Chinese medicine (TCM) has a long history of viewing an individual or patient as a system with different statuses, and has accumulated numerous herbal formulae. The holistic philosophy of TCM shares much with the key ideas of emerging network pharmacology and network biology, and meets the requirements of overcoming complex diseases, such as cancer, in a systematic manner. To discover TCM from a systems perspective and at the molecular level, a novel TCM network pharmacology approach was established by updating the research paradigm from the current "one target, one drug" mode to a new "network target, multi-components" mode. Subsequently, a set of TCM network pharmacology methods were created to prioritize disease-associated genes, to predict the target profiles and pharmacological actions of herbal compounds, to reveal drug-gene-disease co-module associations, to screen synergistic multi-compounds from herbal formulae in a high-throughput manner, and to interpret the combinatorial rules and network regulation effects of herbal formulae. The effectiveness of the network-based methods was demonstrated for the discovery of bioactive compounds and for the elucidation of the mechanisms of action of herbal formulae, such as Qing-Luo-Yin and the Liu-Wei-Di-Huang pill. The studies suggest that the TCM network pharmacology approach provides a new research paradigm for translating TCM from an experience-based medicine to an evidence-based medicine system, which will accelerate TCM drug discovery, and also improve current drug discovery strategies. SN - 1875-5364 UR - https://www.unboundmedicine.com/medline/citation/23787177/Traditional_Chinese_medicine_network_pharmacology:_theory_methodology_and_application_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1875-5364(13)60037-0 DB - PRIME DP - Unbound Medicine ER -