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Propolis reduces oxidative stress in l-NAME-induced hypertension rats.
Cell Biochem Funct. 2014 Mar; 32(2):150-4.CB

Abstract

The inhibition in the synthesis or bioavailability of nitric oxide (NO) has an important role in progress of hypertension. The blocking of nitric oxide synthase activity may cause vasoconstriction with the formation of reactive oxygen species (ROS). Propolis is a resinous substance collected by honey bees from various plants. Propolis has biological and pharmacological properties. The aim of this study was to examine the effect of propolis on catalase (CAT) activity, malondialdehyde (MDA) and NO levels in the testis tissues of hypertensive rats by Nω-nitro-l-arginine methyl ester (l-NAME). Rats have received nitric oxide synthase inhibitor (l-NAME, 40 mg kg(-1) , intraperitoneally) for 15 days to produce hypertension and propolis (200 mg kg(-1) , by gavage) during the last 5 days. MDA level in l-NAME-treated group significantly increased compared with control group (P < 0.01). MDA level of l-NAME + propolis-treated rats significantly reduced (P < 0.01) compared with l-NAME-treated group. CAT activity and NO level significantly reduced (P < 0.01) in l-NAME group compared with control group. There were no statistically significant increases in the CAT activity and NO level of the l-NAME + propolis group compared with the l-NAME-treated group (P > 0.01). These results suggest that propolis changes CAT activity, NO and MDA levels in testis of l-NAME-treated animals, and so it may modulate the antioxidant system.

Authors+Show Affiliations

Department of Biology, Faculty of Arts and Science, Nigde University, Nigde, Turkey.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23788129

Citation

Selamoglu Talas, Zeliha. "Propolis Reduces Oxidative Stress in l-NAME-induced Hypertension Rats." Cell Biochemistry and Function, vol. 32, no. 2, 2014, pp. 150-4.
Selamoglu Talas Z. Propolis reduces oxidative stress in l-NAME-induced hypertension rats. Cell Biochem Funct. 2014;32(2):150-4.
Selamoglu Talas, Z. (2014). Propolis reduces oxidative stress in l-NAME-induced hypertension rats. Cell Biochemistry and Function, 32(2), 150-4. https://doi.org/10.1002/cbf.2986
Selamoglu Talas Z. Propolis Reduces Oxidative Stress in l-NAME-induced Hypertension Rats. Cell Biochem Funct. 2014;32(2):150-4. PubMed PMID: 23788129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Propolis reduces oxidative stress in l-NAME-induced hypertension rats. A1 - Selamoglu Talas,Zeliha, Y1 - 2013/06/21/ PY - 2013/03/22/received PY - 2013/04/19/revised PY - 2013/05/15/accepted PY - 2013/6/22/entrez PY - 2013/6/22/pubmed PY - 2015/1/16/medline KW - Catalase KW - l-NAME KW - malondialdehyde KW - nitric oxide KW - oxidative stress KW - propolis SP - 150 EP - 4 JF - Cell biochemistry and function JO - Cell Biochem Funct VL - 32 IS - 2 N2 - The inhibition in the synthesis or bioavailability of nitric oxide (NO) has an important role in progress of hypertension. The blocking of nitric oxide synthase activity may cause vasoconstriction with the formation of reactive oxygen species (ROS). Propolis is a resinous substance collected by honey bees from various plants. Propolis has biological and pharmacological properties. The aim of this study was to examine the effect of propolis on catalase (CAT) activity, malondialdehyde (MDA) and NO levels in the testis tissues of hypertensive rats by Nω-nitro-l-arginine methyl ester (l-NAME). Rats have received nitric oxide synthase inhibitor (l-NAME, 40 mg kg(-1) , intraperitoneally) for 15 days to produce hypertension and propolis (200 mg kg(-1) , by gavage) during the last 5 days. MDA level in l-NAME-treated group significantly increased compared with control group (P < 0.01). MDA level of l-NAME + propolis-treated rats significantly reduced (P < 0.01) compared with l-NAME-treated group. CAT activity and NO level significantly reduced (P < 0.01) in l-NAME group compared with control group. There were no statistically significant increases in the CAT activity and NO level of the l-NAME + propolis group compared with the l-NAME-treated group (P > 0.01). These results suggest that propolis changes CAT activity, NO and MDA levels in testis of l-NAME-treated animals, and so it may modulate the antioxidant system. SN - 1099-0844 UR - https://www.unboundmedicine.com/medline/citation/23788129/Propolis_reduces_oxidative_stress_in_l_NAME_induced_hypertension_rats_ DB - PRIME DP - Unbound Medicine ER -