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Incorporation and effects of dietary eicosapentaenoate (20:5(n-3)) on plasma and erythrocyte lipids of the marmoset following dietary supplementation with differing levels of linoleic acid.
Biochim Biophys Acta 1990; 1045(2):164-73BB

Abstract

The effect of dietary eicosapentaenoic acid (EPA, 20:5(n-3), as the ethyl ester) on plasma lipid levels and the incorporation of EPA into erythrocyte and plasma lipids were investigated in the marmoset monkey. Marmosets were fed high mixed-fat diets (14.5% total fat) supplemented with or without 0.8% EPA for 30 weeks. Markedly elevated plasma cholesterol (16.4 mmol/l) was induced by an atherogenic-type diet but with EPA supplementation, plasma cholesterol increased to only 6.6 mmol/l. Plasma triacylglycerol levels were not elevated with an atherogenic type diet. Substantial EPA incorporation was evident for plasma phospholipid, triacylglycerol and cholesterol ester fractions. The proportion of docosapentaenoic acid (22:5(n-3)) but not docosahexaenoic acid (22:6(n-3)) was also elevated in these plasma lipid fractions. Greatest incorporation of EPA occurred when it was administered with an atherogenic type diet having a P:M:S (polyunsaturated:monounsaturated:saturated) fatty acid ratio of about 0.2:0.6:1.0 in comparison to the control diet of 1.0:1.0:1.0. Incorporation of EPA and 22:5(n-3)) into erythrocyte phospholipids was also apparent and this was at the expense of linoleic acid (18:2(n-6)). These results in the marmoset highlight both the cholesterol-lowering properties of EPA and the extent of its incorporation into plasma lipids and erythrocyte membrane phospholipids with far greater incorporation occurring when the level of dietary linoleic acid was reduced.

Authors+Show Affiliations

CSIRO (Australia), Division of Human Nutrition, Glenthorne Laboratory, O'Halloran Hill.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2378908

Citation

McMurchie, E J., et al. "Incorporation and Effects of Dietary Eicosapentaenoate (20:5(n-3)) On Plasma and Erythrocyte Lipids of the Marmoset Following Dietary Supplementation With Differing Levels of Linoleic Acid." Biochimica Et Biophysica Acta, vol. 1045, no. 2, 1990, pp. 164-73.
McMurchie EJ, Rinaldi JA, Burnard SL, et al. Incorporation and effects of dietary eicosapentaenoate (20:5(n-3)) on plasma and erythrocyte lipids of the marmoset following dietary supplementation with differing levels of linoleic acid. Biochim Biophys Acta. 1990;1045(2):164-73.
McMurchie, E. J., Rinaldi, J. A., Burnard, S. L., Patten, G. S., Neumann, M., McIntosh, G. H., ... Gibson, R. A. (1990). Incorporation and effects of dietary eicosapentaenoate (20:5(n-3)) on plasma and erythrocyte lipids of the marmoset following dietary supplementation with differing levels of linoleic acid. Biochimica Et Biophysica Acta, 1045(2), pp. 164-73.
McMurchie EJ, et al. Incorporation and Effects of Dietary Eicosapentaenoate (20:5(n-3)) On Plasma and Erythrocyte Lipids of the Marmoset Following Dietary Supplementation With Differing Levels of Linoleic Acid. Biochim Biophys Acta. 1990 Jul 16;1045(2):164-73. PubMed PMID: 2378908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incorporation and effects of dietary eicosapentaenoate (20:5(n-3)) on plasma and erythrocyte lipids of the marmoset following dietary supplementation with differing levels of linoleic acid. AU - McMurchie,E J, AU - Rinaldi,J A, AU - Burnard,S L, AU - Patten,G S, AU - Neumann,M, AU - McIntosh,G H, AU - Abbey,M, AU - Gibson,R A, PY - 1990/7/16/pubmed PY - 1990/7/16/medline PY - 1990/7/16/entrez SP - 164 EP - 73 JF - Biochimica et biophysica acta JO - Biochim. Biophys. Acta VL - 1045 IS - 2 N2 - The effect of dietary eicosapentaenoic acid (EPA, 20:5(n-3), as the ethyl ester) on plasma lipid levels and the incorporation of EPA into erythrocyte and plasma lipids were investigated in the marmoset monkey. Marmosets were fed high mixed-fat diets (14.5% total fat) supplemented with or without 0.8% EPA for 30 weeks. Markedly elevated plasma cholesterol (16.4 mmol/l) was induced by an atherogenic-type diet but with EPA supplementation, plasma cholesterol increased to only 6.6 mmol/l. Plasma triacylglycerol levels were not elevated with an atherogenic type diet. Substantial EPA incorporation was evident for plasma phospholipid, triacylglycerol and cholesterol ester fractions. The proportion of docosapentaenoic acid (22:5(n-3)) but not docosahexaenoic acid (22:6(n-3)) was also elevated in these plasma lipid fractions. Greatest incorporation of EPA occurred when it was administered with an atherogenic type diet having a P:M:S (polyunsaturated:monounsaturated:saturated) fatty acid ratio of about 0.2:0.6:1.0 in comparison to the control diet of 1.0:1.0:1.0. Incorporation of EPA and 22:5(n-3)) into erythrocyte phospholipids was also apparent and this was at the expense of linoleic acid (18:2(n-6)). These results in the marmoset highlight both the cholesterol-lowering properties of EPA and the extent of its incorporation into plasma lipids and erythrocyte membrane phospholipids with far greater incorporation occurring when the level of dietary linoleic acid was reduced. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/2378908/Incorporation_and_effects_of_dietary_eicosapentaenoate__20:5_n_3___on_plasma_and_erythrocyte_lipids_of_the_marmoset_following_dietary_supplementation_with_differing_levels_of_linoleic_acid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0005-2760(90)90146-O DB - PRIME DP - Unbound Medicine ER -