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[Infectious exacerbation of chronic obstructive pulmonary disease: prospects for high-dose levofloxacin therapy].
Klin Med (Mosk) 2013; 91(3):44-50KM

Abstract

This open comparative randomized study of efficacy, safety, and pharmacoeconomic characteristics of hilifox-750 (750 mg daily for 5 days) and amoxiclav 2X (875/125 mg twice daily for 10 days) included 60 patients with chronic obstructive pulmonary disease (COPD). Duration of the study was 6 months. Medians of age and smoking index in the group treated with hilifox-750 were 63.5 yr (59, 67) and 30 packs/yr (15, 60) respectively. The treatment reduced cough, apnea, sputum volume and pyoptysis with comparative rates of normalization of body temperature and peripheral leukocyte counts in both groups. Helifox-750 promoted decrease in coughing and apnea within the first three days of therapy. 28 (93%) and 26 (87%) patients recovered by day 4 of helifox and amoxiclav therapy (F-test p = 0.67). Both drugs showed comparable bacteriological efficacy. They were not different in terms of side effect frequency that were mild, resolved spontaneously and did not require withdrawal of therapy. Helifox had advantages over amoxiclav in that it reduced duration of antibacterial therapy to 5 days and of temporary incapacity to 12 days (vs 14); moreover, it needs to be taken only once daily.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

rus

PubMed ID

23789452

Citation

Astaf'ev, A V., et al. "[Infectious Exacerbation of Chronic Obstructive Pulmonary Disease: Prospects for High-dose Levofloxacin Therapy]." Klinicheskaia Meditsina, vol. 91, no. 3, 2013, pp. 44-50.
Astaf'ev AV, Styrt EA, Sinopal'nikov AI. [Infectious exacerbation of chronic obstructive pulmonary disease: prospects for high-dose levofloxacin therapy]. Klin Med (Mosk). 2013;91(3):44-50.
Astaf'ev, A. V., Styrt, E. A., & Sinopal'nikov, A. I. (2013). [Infectious exacerbation of chronic obstructive pulmonary disease: prospects for high-dose levofloxacin therapy]. Klinicheskaia Meditsina, 91(3), pp. 44-50.
Astaf'ev AV, Styrt EA, Sinopal'nikov AI. [Infectious Exacerbation of Chronic Obstructive Pulmonary Disease: Prospects for High-dose Levofloxacin Therapy]. Klin Med (Mosk). 2013;91(3):44-50. PubMed PMID: 23789452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Infectious exacerbation of chronic obstructive pulmonary disease: prospects for high-dose levofloxacin therapy]. AU - Astaf'ev,A V, AU - Styrt,E A, AU - Sinopal'nikov,A I, PY - 2013/6/25/entrez PY - 2013/6/26/pubmed PY - 2013/7/10/medline SP - 44 EP - 50 JF - Klinicheskaia meditsina JO - Klin Med (Mosk) VL - 91 IS - 3 N2 - This open comparative randomized study of efficacy, safety, and pharmacoeconomic characteristics of hilifox-750 (750 mg daily for 5 days) and amoxiclav 2X (875/125 mg twice daily for 10 days) included 60 patients with chronic obstructive pulmonary disease (COPD). Duration of the study was 6 months. Medians of age and smoking index in the group treated with hilifox-750 were 63.5 yr (59, 67) and 30 packs/yr (15, 60) respectively. The treatment reduced cough, apnea, sputum volume and pyoptysis with comparative rates of normalization of body temperature and peripheral leukocyte counts in both groups. Helifox-750 promoted decrease in coughing and apnea within the first three days of therapy. 28 (93%) and 26 (87%) patients recovered by day 4 of helifox and amoxiclav therapy (F-test p = 0.67). Both drugs showed comparable bacteriological efficacy. They were not different in terms of side effect frequency that were mild, resolved spontaneously and did not require withdrawal of therapy. Helifox had advantages over amoxiclav in that it reduced duration of antibacterial therapy to 5 days and of temporary incapacity to 12 days (vs 14); moreover, it needs to be taken only once daily. SN - 0023-2149 UR - https://www.unboundmedicine.com/medline/citation/23789452/[Infectious_exacerbation_of_chronic_obstructive_pulmonary_disease:_prospects_for_high-dose_levofloxacin_therapy] L2 - http://www.diseaseinfosearch.org/result/6084 DB - PRIME DP - Unbound Medicine ER -