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Tyrosol exerts a protective effect against dopaminergic neuronal cell death in in vitro model of Parkinson's disease.
Food Chem. 2013 Nov 15; 141(2):1147-57.FC

Abstract

Experimental evidence suggests that tyrosol [2-(4-hydroxyphenyl)ethanol] exhibits potent protective activities against several pathogeneses. In this study, we evaluated the protective effect of tyrosol against 1-methyl-4-phenylpyridinium (MPP(+))-induced CATH.a neuron cell death. Tyrosol dose-dependently protected CATH.a cells from MPP(+)-induced cell death and the protection was more apparent after prolong incubation (48h). The data showed that tyrosol treatment suppressed the reduction of phospho-tyrosine hydroxylase level in CATH.a cells. Further, the compound repressed MPP(+)-induced depletion of mitochondrial membrane potential (Δψm) and thereby maintained intracellular ATP production in the cell. The cellular signalling pathway studies revealed that tyrosol protected CATH.a cells from MPP(+)-induced apoptotic signalling, most likely via activation of PI3K/Akt signalling pathway along with up-regulation of anti-oxidative enzymes (SOD-1 and SOD-2) and DJ-1 protein in the cell. Collectively, present study demonstrates that tyrosol significantly protects dopaminergic neurons from MPP(+)-induced degradation, and reveals potential neuroprotective mechanism of tyrosol.

Authors+Show Affiliations

Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23790897

Citation

Dewapriya, Pradeep, et al. "Tyrosol Exerts a Protective Effect Against Dopaminergic Neuronal Cell Death in in Vitro Model of Parkinson's Disease." Food Chemistry, vol. 141, no. 2, 2013, pp. 1147-57.
Dewapriya P, Himaya SW, Li YX, et al. Tyrosol exerts a protective effect against dopaminergic neuronal cell death in in vitro model of Parkinson's disease. Food Chem. 2013;141(2):1147-57.
Dewapriya, P., Himaya, S. W., Li, Y. X., & Kim, S. K. (2013). Tyrosol exerts a protective effect against dopaminergic neuronal cell death in in vitro model of Parkinson's disease. Food Chemistry, 141(2), 1147-57. https://doi.org/10.1016/j.foodchem.2013.04.004
Dewapriya P, et al. Tyrosol Exerts a Protective Effect Against Dopaminergic Neuronal Cell Death in in Vitro Model of Parkinson's Disease. Food Chem. 2013 Nov 15;141(2):1147-57. PubMed PMID: 23790897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tyrosol exerts a protective effect against dopaminergic neuronal cell death in in vitro model of Parkinson's disease. AU - Dewapriya,Pradeep, AU - Himaya,S W A, AU - Li,Yong-Xin, AU - Kim,Se-Kwon, Y1 - 2013/04/13/ PY - 2012/12/15/received PY - 2013/04/01/revised PY - 2013/04/04/accepted PY - 2013/6/25/entrez PY - 2013/6/26/pubmed PY - 2014/1/5/medline SP - 1147 EP - 57 JF - Food chemistry JO - Food Chem VL - 141 IS - 2 N2 - Experimental evidence suggests that tyrosol [2-(4-hydroxyphenyl)ethanol] exhibits potent protective activities against several pathogeneses. In this study, we evaluated the protective effect of tyrosol against 1-methyl-4-phenylpyridinium (MPP(+))-induced CATH.a neuron cell death. Tyrosol dose-dependently protected CATH.a cells from MPP(+)-induced cell death and the protection was more apparent after prolong incubation (48h). The data showed that tyrosol treatment suppressed the reduction of phospho-tyrosine hydroxylase level in CATH.a cells. Further, the compound repressed MPP(+)-induced depletion of mitochondrial membrane potential (Δψm) and thereby maintained intracellular ATP production in the cell. The cellular signalling pathway studies revealed that tyrosol protected CATH.a cells from MPP(+)-induced apoptotic signalling, most likely via activation of PI3K/Akt signalling pathway along with up-regulation of anti-oxidative enzymes (SOD-1 and SOD-2) and DJ-1 protein in the cell. Collectively, present study demonstrates that tyrosol significantly protects dopaminergic neurons from MPP(+)-induced degradation, and reveals potential neuroprotective mechanism of tyrosol. SN - 1873-7072 UR - https://www.unboundmedicine.com/medline/citation/23790897/Tyrosol_exerts_a_protective_effect_against_dopaminergic_neuronal_cell_death_in_in_vitro_model_of_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0308-8146(13)00427-5 DB - PRIME DP - Unbound Medicine ER -