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Infusion of galanin into the mid-caudal portion of the dorsal raphe nucleus has an anxiolytic effect on rats in the elevated T-maze.
Behav Brain Res. 2013 Sep 01; 252:312-7.BB

Abstract

Galanin and 5-HT coexist in dorsal raphe nucleus (DRN) neurons. Microinjection of galanin into the DRN reduces the firing rate of serotonin neurons. Serotonergic neurons projecting from the DRN to the amygdala facilitate learned anxiety producing an anxiogenic effect, while those projecting from the periaqueductal grey affect innate anxiety producing a panicolytic effect. We tested the hypothesis that injection of galanin into rat DRN would induce anxiolytic/panicogenic effects in the elevated T-maze (ETM), a model that allows for the evaluation of both of these effects. Galanin infusion into the mid-caudal DRN, but not into the rostral DRN, impaired inhibitory avoidance, suggesting an anxiolytic effect. The effective dose of galanin (0.3 nmol) did not modify locomotor activity in the open field. Contrary to expectations, microinjection of galanin into the DRN did not facilitate the latency of one-way escape in the ETM. Pretreatment with a galanin antagonist, M40, attenuated galanin-induced impairment of inhibitory avoidance. The results show that microinjection of a low dose of galanin only into the mid-caudal DRN has an anxiolytic effect. This effect seems to be mediated, at least in part, by galanin receptors. Further investigation is necessary to identify the receptor subtypes and the DRN subregion involved in the anxiolytic effect of galanin.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Health Science Center, Federal University of Espirito Santo, Vitoria, ES 29043-900, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23791934

Citation

Silote, Gabriela Pandini, et al. "Infusion of Galanin Into the Mid-caudal Portion of the Dorsal Raphe Nucleus Has an Anxiolytic Effect On Rats in the Elevated T-maze." Behavioural Brain Research, vol. 252, 2013, pp. 312-7.
Silote GP, Rosal AB, de Souza MM, et al. Infusion of galanin into the mid-caudal portion of the dorsal raphe nucleus has an anxiolytic effect on rats in the elevated T-maze. Behav Brain Res. 2013;252:312-7.
Silote, G. P., Rosal, A. B., de Souza, M. M., & Beijamini, V. (2013). Infusion of galanin into the mid-caudal portion of the dorsal raphe nucleus has an anxiolytic effect on rats in the elevated T-maze. Behavioural Brain Research, 252, 312-7. https://doi.org/10.1016/j.bbr.2013.06.023
Silote GP, et al. Infusion of Galanin Into the Mid-caudal Portion of the Dorsal Raphe Nucleus Has an Anxiolytic Effect On Rats in the Elevated T-maze. Behav Brain Res. 2013 Sep 1;252:312-7. PubMed PMID: 23791934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infusion of galanin into the mid-caudal portion of the dorsal raphe nucleus has an anxiolytic effect on rats in the elevated T-maze. AU - Silote,Gabriela Pandini, AU - Rosal,Aline Boroto, AU - de Souza,Mayara Machado, AU - Beijamini,Vanessa, Y1 - 2013/06/19/ PY - 2013/05/31/received PY - 2013/06/14/revised PY - 2013/06/16/accepted PY - 2013/6/25/entrez PY - 2013/6/25/pubmed PY - 2013/10/29/medline KW - Anxiety KW - Dorsal raphe nucleus KW - Elevated T-maze KW - Galanin SP - 312 EP - 7 JF - Behavioural brain research JO - Behav Brain Res VL - 252 N2 - Galanin and 5-HT coexist in dorsal raphe nucleus (DRN) neurons. Microinjection of galanin into the DRN reduces the firing rate of serotonin neurons. Serotonergic neurons projecting from the DRN to the amygdala facilitate learned anxiety producing an anxiogenic effect, while those projecting from the periaqueductal grey affect innate anxiety producing a panicolytic effect. We tested the hypothesis that injection of galanin into rat DRN would induce anxiolytic/panicogenic effects in the elevated T-maze (ETM), a model that allows for the evaluation of both of these effects. Galanin infusion into the mid-caudal DRN, but not into the rostral DRN, impaired inhibitory avoidance, suggesting an anxiolytic effect. The effective dose of galanin (0.3 nmol) did not modify locomotor activity in the open field. Contrary to expectations, microinjection of galanin into the DRN did not facilitate the latency of one-way escape in the ETM. Pretreatment with a galanin antagonist, M40, attenuated galanin-induced impairment of inhibitory avoidance. The results show that microinjection of a low dose of galanin only into the mid-caudal DRN has an anxiolytic effect. This effect seems to be mediated, at least in part, by galanin receptors. Further investigation is necessary to identify the receptor subtypes and the DRN subregion involved in the anxiolytic effect of galanin. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/23791934/Infusion_of_galanin_into_the_mid_caudal_portion_of_the_dorsal_raphe_nucleus_has_an_anxiolytic_effect_on_rats_in_the_elevated_T_maze_ DB - PRIME DP - Unbound Medicine ER -