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Modulating efficacy of Rebaudioside A, a diterpenoid on antioxidant and circulatory lipids in experimental diabetic rats.
Environ Toxicol Pharmacol. 2013 Sep; 36(2):472-483.ET

Abstract

The present study was to evaluate the protective effects of Rebaudioside A (Reb A) on antioxidant status and lipid profile in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in Wistar rats by a single intraperitoneal administration of STZ (40mg/kg b.w). Diabetic rats showed significantly increased levels of plasma glucose, thiobarbituric acid reactive substances, hydroperoxides and decreased levels of insulin. The activity of enzymatic antioxidants (superoxide dismutase, catalase and glutathione peroxidase) and the levels of non enzymatic antioxidants (vitamin C, vitamin E and reduced glutathione) were decreased in diabetic rats. The levels of total cholesterol (TC), triglycerides (TGs), free fatty acids (FFAs), phospholipids (PLs), low density lipoproteins (LDL-cholesterol) and very low-density lipoproteins (VLDL-cholesterol) in the plasma significantly increased, while plasma high-density lipoproteins (HDL-cholesterol) were significantly decreased in diabetic rats. Oral administration of Reb A (200mg/kg b.w) brought back plasma glucose, insulin, lipid peroxidation products, enzymatic, non-enzymatic antioxidants and lipid profile levels to near normal. The results of the present investigation suggests that Reb A, a natural sweetener exhibits antilipid peroxidative, antihyperlipidemic and antioxidant properties.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India. Electronic address: jayamsaranbio@gmail.com.Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23792234

Citation

Saravanan, Ramalingam, and Vinayagam Ramachandran. "Modulating Efficacy of Rebaudioside A, a Diterpenoid On Antioxidant and Circulatory Lipids in Experimental Diabetic Rats." Environmental Toxicology and Pharmacology, vol. 36, no. 2, 2013, pp. 472-483.
Saravanan R, Ramachandran V. Modulating efficacy of Rebaudioside A, a diterpenoid on antioxidant and circulatory lipids in experimental diabetic rats. Environ Toxicol Pharmacol. 2013;36(2):472-483.
Saravanan, R., & Ramachandran, V. (2013). Modulating efficacy of Rebaudioside A, a diterpenoid on antioxidant and circulatory lipids in experimental diabetic rats. Environmental Toxicology and Pharmacology, 36(2), 472-483. https://doi.org/10.1016/j.etap.2013.05.009
Saravanan R, Ramachandran V. Modulating Efficacy of Rebaudioside A, a Diterpenoid On Antioxidant and Circulatory Lipids in Experimental Diabetic Rats. Environ Toxicol Pharmacol. 2013;36(2):472-483. PubMed PMID: 23792234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulating efficacy of Rebaudioside A, a diterpenoid on antioxidant and circulatory lipids in experimental diabetic rats. AU - Saravanan,Ramalingam, AU - Ramachandran,Vinayagam, Y1 - 2013/06/03/ PY - 2013/02/08/received PY - 2013/05/10/revised PY - 2013/05/24/accepted PY - 2013/6/25/entrez PY - 2013/6/25/pubmed PY - 2014/3/13/medline KW - Diabetes KW - Lipid profile KW - Oxidative stress KW - Rebaudioside A KW - Streptozotocin SP - 472 EP - 483 JF - Environmental toxicology and pharmacology JO - Environ Toxicol Pharmacol VL - 36 IS - 2 N2 - The present study was to evaluate the protective effects of Rebaudioside A (Reb A) on antioxidant status and lipid profile in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in Wistar rats by a single intraperitoneal administration of STZ (40mg/kg b.w). Diabetic rats showed significantly increased levels of plasma glucose, thiobarbituric acid reactive substances, hydroperoxides and decreased levels of insulin. The activity of enzymatic antioxidants (superoxide dismutase, catalase and glutathione peroxidase) and the levels of non enzymatic antioxidants (vitamin C, vitamin E and reduced glutathione) were decreased in diabetic rats. The levels of total cholesterol (TC), triglycerides (TGs), free fatty acids (FFAs), phospholipids (PLs), low density lipoproteins (LDL-cholesterol) and very low-density lipoproteins (VLDL-cholesterol) in the plasma significantly increased, while plasma high-density lipoproteins (HDL-cholesterol) were significantly decreased in diabetic rats. Oral administration of Reb A (200mg/kg b.w) brought back plasma glucose, insulin, lipid peroxidation products, enzymatic, non-enzymatic antioxidants and lipid profile levels to near normal. The results of the present investigation suggests that Reb A, a natural sweetener exhibits antilipid peroxidative, antihyperlipidemic and antioxidant properties. SN - 1872-7077 UR - https://www.unboundmedicine.com/medline/citation/23792234/Modulating_efficacy_of_Rebaudioside_A_a_diterpenoid_on_antioxidant_and_circulatory_lipids_in_experimental_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1382-6689(13)00122-1 DB - PRIME DP - Unbound Medicine ER -