Tags

Type your tag names separated by a space and hit enter

Synthesis and antitumor activity evaluation of a novel series of camptothecin analogs.
J Asian Nat Prod Res. 2013; 15(8):867-74.JA

Abstract

A series of novel 10-substituted camptothecin analogs (3-10) with a carbamate linker were synthesized, and their biological activities were evaluated. The amino acid-linked carbamate derivatives (8-10) of the camptothecin-type natural product not only possessed good to excellent inhibitory activity against three human tumor cell lines K562, HepG2, and HT-29, but also showed significantly less cytotoxicity against normal human cell HEK293 (half maximal inhibiting concentration >10 μM). The selectivity of compound 9 toward tumor cells relative to normal cells is at least 250 times better than that of camptothecin. The preliminary testing result indicated that the solubility of these compounds was also improved compared to that of 10-hydroxy camptothecin.

Authors+Show Affiliations

a Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology , Tianjin , 300457 , China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23796391

Citation

Lv, Jian, et al. "Synthesis and Antitumor Activity Evaluation of a Novel Series of Camptothecin Analogs." Journal of Asian Natural Products Research, vol. 15, no. 8, 2013, pp. 867-74.
Lv J, Guo N, Wen SP, et al. Synthesis and antitumor activity evaluation of a novel series of camptothecin analogs. J Asian Nat Prod Res. 2013;15(8):867-74.
Lv, J., Guo, N., Wen, S. P., Teng, Y. O., Ma, M. X., & Yu, P. (2013). Synthesis and antitumor activity evaluation of a novel series of camptothecin analogs. Journal of Asian Natural Products Research, 15(8), 867-74. https://doi.org/10.1080/10286020.2013.804068
Lv J, et al. Synthesis and Antitumor Activity Evaluation of a Novel Series of Camptothecin Analogs. J Asian Nat Prod Res. 2013;15(8):867-74. PubMed PMID: 23796391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and antitumor activity evaluation of a novel series of camptothecin analogs. AU - Lv,Jian, AU - Guo,Na, AU - Wen,Shao-Peng, AU - Teng,Yu-Ou, AU - Ma,Meng-Xin, AU - Yu,Peng, Y1 - 2013/06/25/ PY - 2013/6/26/entrez PY - 2013/6/26/pubmed PY - 2013/11/15/medline SP - 867 EP - 74 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 15 IS - 8 N2 - A series of novel 10-substituted camptothecin analogs (3-10) with a carbamate linker were synthesized, and their biological activities were evaluated. The amino acid-linked carbamate derivatives (8-10) of the camptothecin-type natural product not only possessed good to excellent inhibitory activity against three human tumor cell lines K562, HepG2, and HT-29, but also showed significantly less cytotoxicity against normal human cell HEK293 (half maximal inhibiting concentration >10 μM). The selectivity of compound 9 toward tumor cells relative to normal cells is at least 250 times better than that of camptothecin. The preliminary testing result indicated that the solubility of these compounds was also improved compared to that of 10-hydroxy camptothecin. SN - 1477-2213 UR - https://www.unboundmedicine.com/medline/citation/23796391/Synthesis_and_antitumor_activity_evaluation_of_a_novel_series_of_camptothecin_analogs_ L2 - http://www.tandfonline.com/doi/full/10.1080/10286020.2013.804068 DB - PRIME DP - Unbound Medicine ER -