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Associations of the PTEN -9C>G polymorphism with insulin sensitivity and central obesity in Chinese.
Gene 2013; 527(2):545-52GENE

Abstract

BACKGROUND

Phosphatase and tensin homolog on chromosome 10 gene (PTEN) is known as a tumor-suppressor gene. Previous studies demonstrated that PTEN dysfunction affects the function of insulin. However, investigations of PTEN single nucleotide polymorphisms (SNPs) and IR-related disease associations are limited. The aim of the present study was to investigate whether its polymorphism could be involved in the risk of metabolic syndrome (MetS).

METHODS

The genotype frequency of PTEN -9C>G polymorphism was determined by using a Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) method in 530 subjects with MetS and 202 healthy control subjects of the Han Ethnic Chinese population in a case-control analysis.

RESULTS

The PTEN -9C>G polymorphism was not associated with MetS or its hyperglycemia, hypertension and hypertriglyceridemia components. In the control individuals aged <60 years or ≥60 years, the CG genotype individuals had lower insulin sensitivity than CC individuals (P<0.05). In the <60-year-old MetS group and normal glucose tolerance (NGT) subgroup, the CG individuals had lower insulin sensitivity and higher waist circumference (WC) and waist-height-ratio (WHtR) than CC individuals (P<0.05). Multiple linear regression analysis showed that the PTEN polymorphism (P=0.001) contributed independently to 4.2% (adjusted R(2)) of insulin sensitivity variance (estimated by Matsuda ISI), while age (P=0.004), gender (P=0.000) and the PTEN polymorphism (P=0.032) contributed independently to 5.6% (adjusted R(2)) of WHtR variance.

CONCLUSIONS

The CG genotype of PTEN -9C>G polymorphism was not associated with MetS and some of its components as well. However, it may not only decrease insulin sensitivity in the healthy control and MetS in pre-elderly or NGT subjects, but may also increase the risk of central obesity among these MetS individuals.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23796801

Citation

Yang, Qiu, et al. "Associations of the PTEN -9C>G Polymorphism With Insulin Sensitivity and Central Obesity in Chinese." Gene, vol. 527, no. 2, 2013, pp. 545-52.
Yang Q, Cao H, Xie S, et al. Associations of the PTEN -9C>G polymorphism with insulin sensitivity and central obesity in Chinese. Gene. 2013;527(2):545-52.
Yang, Q., Cao, H., Xie, S., Tong, Y., Zhu, Q., Zhang, F., ... Tong, N. (2013). Associations of the PTEN -9C>G polymorphism with insulin sensitivity and central obesity in Chinese. Gene, 527(2), pp. 545-52. doi:10.1016/j.gene.2013.06.026.
Yang Q, et al. Associations of the PTEN -9C>G Polymorphism With Insulin Sensitivity and Central Obesity in Chinese. Gene. 2013 Sep 25;527(2):545-52. PubMed PMID: 23796801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of the PTEN -9C>G polymorphism with insulin sensitivity and central obesity in Chinese. AU - Yang,Qiu, AU - Cao,Hongyi, AU - Xie,Shugui, AU - Tong,Yuzhen, AU - Zhu,Qibo, AU - Zhang,Fang, AU - Lü,Qingguo, AU - Yang,Yan, AU - Li,Daigang, AU - Chen,Mei, AU - Yu,Changyong, AU - Jin,Wei, AU - Yuan,Yuquan, AU - Tong,Nanwei, Y1 - 2013/06/21/ PY - 2013/01/20/received PY - 2013/04/28/revised PY - 2013/06/03/accepted PY - 2013/6/26/entrez PY - 2013/6/26/pubmed PY - 2013/10/31/medline KW - ANOVA KW - BMI KW - CI KW - CVD KW - Central obesity KW - DM KW - HOMA-IR KW - HOMA-β KW - HbA1c KW - IR KW - Insulin resistance KW - MALDI-TOF MS KW - MMAC1 KW - Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry KW - Matsuda ISI KW - Matsuda insulin sensitivity index KW - MetS KW - Metabolic syndrome KW - NAFLD KW - NGT KW - OGTT KW - OR KW - PD KW - PI3K KW - PIP2 KW - PIP3 KW - PKA KW - PKC KW - PTEN KW - SNP KW - TEP1 KW - TGFβ-regulated and epithelial cell-enriched phosphatase 1 KW - WC KW - WHtR KW - analysis of variance KW - body mass index KW - cardiovascular disease KW - confidence interval KW - glycated hemoglobin KW - homeostasis model assessments of insulin resistance KW - homeostasis model assessments of β-cell function KW - insulin resistance KW - metabolic syndrome KW - multiple advanced cancers 1 KW - nonalcoholic fatty liver disease KW - normal glucose tolerance KW - odds ratio KW - oral glucose tolerance test KW - phosphatase and tensin homolog on chromosome 10 KW - phosphatidylinositol (PI) 3-kinase KW - phosphatidylinositol-3,4,5-trisphosphate KW - phosphatidylinositol-4,5-bisphosphate KW - prediabetes KW - protein kinase A KW - protein kinase C KW - single nucleotide polymorphism KW - type 2 diabetes mellitus KW - waist circumference KW - waist circumference/height SP - 545 EP - 52 JF - Gene JO - Gene VL - 527 IS - 2 N2 - BACKGROUND: Phosphatase and tensin homolog on chromosome 10 gene (PTEN) is known as a tumor-suppressor gene. Previous studies demonstrated that PTEN dysfunction affects the function of insulin. However, investigations of PTEN single nucleotide polymorphisms (SNPs) and IR-related disease associations are limited. The aim of the present study was to investigate whether its polymorphism could be involved in the risk of metabolic syndrome (MetS). METHODS: The genotype frequency of PTEN -9C>G polymorphism was determined by using a Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) method in 530 subjects with MetS and 202 healthy control subjects of the Han Ethnic Chinese population in a case-control analysis. RESULTS: The PTEN -9C>G polymorphism was not associated with MetS or its hyperglycemia, hypertension and hypertriglyceridemia components. In the control individuals aged <60 years or ≥60 years, the CG genotype individuals had lower insulin sensitivity than CC individuals (P<0.05). In the <60-year-old MetS group and normal glucose tolerance (NGT) subgroup, the CG individuals had lower insulin sensitivity and higher waist circumference (WC) and waist-height-ratio (WHtR) than CC individuals (P<0.05). Multiple linear regression analysis showed that the PTEN polymorphism (P=0.001) contributed independently to 4.2% (adjusted R(2)) of insulin sensitivity variance (estimated by Matsuda ISI), while age (P=0.004), gender (P=0.000) and the PTEN polymorphism (P=0.032) contributed independently to 5.6% (adjusted R(2)) of WHtR variance. CONCLUSIONS: The CG genotype of PTEN -9C>G polymorphism was not associated with MetS and some of its components as well. However, it may not only decrease insulin sensitivity in the healthy control and MetS in pre-elderly or NGT subjects, but may also increase the risk of central obesity among these MetS individuals. SN - 1879-0038 UR - https://www.unboundmedicine.com/medline/citation/23796801/Associations_of_the_PTEN__9C>G_polymorphism_with_insulin_sensitivity_and_central_obesity_in_Chinese_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1119(13)00783-X DB - PRIME DP - Unbound Medicine ER -