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Reactions to honeybee stings: an allergic prospective.
Curr Opin Allergy Clin Immunol 2013; 13(4):365-71CO

Abstract

PURPOSE OF REVIEW

The purpose of this article is to provide a brief overview of the events involved in honeybee allergy and to concisely update the reader on progress toward knowledge of honeybee venom (HBV), strides in solving diagnostic difficulties, and advancements in improving safety and efficacy of HBV immunotherapy.

RECENT FINDINGS

It is well known that honeybee allergy is unique in venom allergen and protein composition, diagnostic challenges, and immunotherapy safety and efficacy. Many new honeybee allergens have been recognized. Advances in testing, evaluation, and extract manipulation methods, many using recombinant technology, have allowed a greater ability to help with honeybee allergy diagnosis and resultant improvement in immunotherapy safety and evaluation of immunotherapy efficacy.

SUMMARY

In an effort to address many honeybee allergy concerns, specific advances have been recently made. Some recently characterized honeybee allergens appear to be major contributors to honeybee allergy. In the setting of double-positivity, cross-reacting carbohydrate determinants and other cross-reacting components in HBV have made diagnosis of honeybee allergy challenging. Recombinant technology, including component-resolved diagnostics, and other evolving testing methods should help clarify double-positivity, if not now, in the very near future. Purified HBV and possibly depot formulations for immunotherapy appear to make it more well tolerated. Recombinant methods may help with evaluation of immunotherapy's safety and efficacy.

Authors+Show Affiliations

Department of Medicine, Allergy/Immunology Clinic, Keesler Medical Center, Biloxi, Mississippi 39534, USA. tyson.brown@us.af.mil

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23799332

Citation

Brown, Tyson C.. "Reactions to Honeybee Stings: an Allergic Prospective." Current Opinion in Allergy and Clinical Immunology, vol. 13, no. 4, 2013, pp. 365-71.
Brown TC. Reactions to honeybee stings: an allergic prospective. Curr Opin Allergy Clin Immunol. 2013;13(4):365-71.
Brown, T. C. (2013). Reactions to honeybee stings: an allergic prospective. Current Opinion in Allergy and Clinical Immunology, 13(4), pp. 365-71. doi:10.1097/ACI.0b013e3283625144.
Brown TC. Reactions to Honeybee Stings: an Allergic Prospective. Curr Opin Allergy Clin Immunol. 2013;13(4):365-71. PubMed PMID: 23799332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reactions to honeybee stings: an allergic prospective. A1 - Brown,Tyson C, PY - 2013/6/27/entrez PY - 2013/6/27/pubmed PY - 2014/2/5/medline SP - 365 EP - 71 JF - Current opinion in allergy and clinical immunology JO - Curr Opin Allergy Clin Immunol VL - 13 IS - 4 N2 - PURPOSE OF REVIEW: The purpose of this article is to provide a brief overview of the events involved in honeybee allergy and to concisely update the reader on progress toward knowledge of honeybee venom (HBV), strides in solving diagnostic difficulties, and advancements in improving safety and efficacy of HBV immunotherapy. RECENT FINDINGS: It is well known that honeybee allergy is unique in venom allergen and protein composition, diagnostic challenges, and immunotherapy safety and efficacy. Many new honeybee allergens have been recognized. Advances in testing, evaluation, and extract manipulation methods, many using recombinant technology, have allowed a greater ability to help with honeybee allergy diagnosis and resultant improvement in immunotherapy safety and evaluation of immunotherapy efficacy. SUMMARY: In an effort to address many honeybee allergy concerns, specific advances have been recently made. Some recently characterized honeybee allergens appear to be major contributors to honeybee allergy. In the setting of double-positivity, cross-reacting carbohydrate determinants and other cross-reacting components in HBV have made diagnosis of honeybee allergy challenging. Recombinant technology, including component-resolved diagnostics, and other evolving testing methods should help clarify double-positivity, if not now, in the very near future. Purified HBV and possibly depot formulations for immunotherapy appear to make it more well tolerated. Recombinant methods may help with evaluation of immunotherapy's safety and efficacy. SN - 1473-6322 UR - https://www.unboundmedicine.com/medline/citation/23799332/Reactions_to_honeybee_stings:_an_allergic_prospective_ L2 - http://Insights.ovid.com/pubmed?pmid=23799332 DB - PRIME DP - Unbound Medicine ER -