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Evidence of preventive effect of probiotics and prebiotics for infantile eczema.

Abstract

PURPOSE OF REVIEW

Infantile eczema, and in particular atopic dermatitis are, in many children, the first manifestation of their predisposition to an atopic disease. Among existing prevention strategies, supplementation with probiotics and prebiotics belong to the most promising beneficial interventions. Highlighting the most recent literature, we review here the most recent studies on probiotics and prebiotics and hypothesize on the most efficient intervention strategies.

RECENT FINDINGS

Various probiotics and prebiotics, either alone or in combinations, have been administered, in general, during the late phase of pregnancy and up to 6 months of age. In general, a combination of probiotics and prebiotics given from pregnancy until early infancy has a higher potential for protecting the infant from developing early manifestations of eczema than short administration of one specific microorganism.

SUMMARY

The effect of probiotics and prebiotic supplementations on early manifestations of atopy such as infantile eczema are conflicting. Nevertheless, prevention strategies should aim for an enhanced efficacy by addressing not only interventions on the microbiota, but by combining them to other interventions, for example, to those aiming at actively inducing antigen-specific tolerance.

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  • Publisher Full Text
  • Authors+Show Affiliations

    University Hospitals of Geneva and Medical School of The University of Geneva, Department of Child and Adolescent, Geneva, Switzerland. Philippe.Eigenmann@hcuge.ch

    Source

    MeSH

    Dermatitis, Atopic
    Dietary Supplements
    Female
    Humans
    Infant
    Infant, Newborn
    Male
    Prebiotics
    Pregnancy
    Probiotics

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    23799337

    Citation

    Eigenmann, Philippe A.. "Evidence of Preventive Effect of Probiotics and Prebiotics for Infantile Eczema." Current Opinion in Allergy and Clinical Immunology, vol. 13, no. 4, 2013, pp. 426-31.
    Eigenmann PA. Evidence of preventive effect of probiotics and prebiotics for infantile eczema. Curr Opin Allergy Clin Immunol. 2013;13(4):426-31.
    Eigenmann, P. A. (2013). Evidence of preventive effect of probiotics and prebiotics for infantile eczema. Current Opinion in Allergy and Clinical Immunology, 13(4), pp. 426-31. doi:10.1097/ACI.0b013e3283630bad.
    Eigenmann PA. Evidence of Preventive Effect of Probiotics and Prebiotics for Infantile Eczema. Curr Opin Allergy Clin Immunol. 2013;13(4):426-31. PubMed PMID: 23799337.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Evidence of preventive effect of probiotics and prebiotics for infantile eczema. A1 - Eigenmann,Philippe A, PY - 2013/6/27/entrez PY - 2013/6/27/pubmed PY - 2014/2/5/medline SP - 426 EP - 31 JF - Current opinion in allergy and clinical immunology JO - Curr Opin Allergy Clin Immunol VL - 13 IS - 4 N2 - PURPOSE OF REVIEW: Infantile eczema, and in particular atopic dermatitis are, in many children, the first manifestation of their predisposition to an atopic disease. Among existing prevention strategies, supplementation with probiotics and prebiotics belong to the most promising beneficial interventions. Highlighting the most recent literature, we review here the most recent studies on probiotics and prebiotics and hypothesize on the most efficient intervention strategies. RECENT FINDINGS: Various probiotics and prebiotics, either alone or in combinations, have been administered, in general, during the late phase of pregnancy and up to 6 months of age. In general, a combination of probiotics and prebiotics given from pregnancy until early infancy has a higher potential for protecting the infant from developing early manifestations of eczema than short administration of one specific microorganism. SUMMARY: The effect of probiotics and prebiotic supplementations on early manifestations of atopy such as infantile eczema are conflicting. Nevertheless, prevention strategies should aim for an enhanced efficacy by addressing not only interventions on the microbiota, but by combining them to other interventions, for example, to those aiming at actively inducing antigen-specific tolerance. SN - 1473-6322 UR - https://www.unboundmedicine.com/medline/citation/23799337/Evidence_of_preventive_effect_of_probiotics_and_prebiotics_for_infantile_eczema_ L2 - http://Insights.ovid.com/pubmed?pmid=23799337 DB - PRIME DP - Unbound Medicine ER -