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Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury.
BMC Surg. 2013 Jun 24; 13:21.BS

Abstract

BACKGROUND

Peripheral nerve (PN) transplantation and ventral root implantation are the two common types of recovery operations to restore the connection between motoneurons and their target muscles after brachial plexus injury. Despite experience accumulated over the past decade, fundamental knowledge is still lacking concerning the efficacy of the two microsurgical interventions.

METHODS

Thirty-eight adult female Sprague-Dawley rats were divided into 5 groups. Immediately following root avulsion, animals in the first group (n = 8) and the second group (n = 8) received PN graft and ventral root implantation respectively. The third group (n = 8) and the fourth group (n = 8) received PN graft and ventral root implantation respectively at one week after root avulsion. The fifth group received root avulsion only as control (n = 6). The survival and axonal regeneration of severed motoneurons were investigated at 6 weeks post-implantation.

RESULTS

Re-implantation of ventral roots, both immediately after root avulsion and in delay, significantly increased the survival and regeneration of motoneurons in the avulsed segment of the spinal cord as compared with PN graft transplantation.

CONCLUSIONS

The ventral root re-implantation is a better surgical repairing procedure than PN graft transplantation for brachial plexus injury because of its easier manipulation for re-implanting avulsed ventral roots to the preferred site, less possibility of causing additional damage and better effects on motoneuron survival and axonal regeneration.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23799915

Citation

Su, Huanxing, et al. "Ventral Root Re-implantation Is Better Than Peripheral Nerve Transplantation for Motoneuron Survival and Regeneration After Spinal Root Avulsion Injury." BMC Surgery, vol. 13, 2013, p. 21.
Su H, Yuan Q, Qin D, et al. Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury. BMC Surg. 2013;13:21.
Su, H., Yuan, Q., Qin, D., Yang, X., Wong, W. M., So, K. F., & Wu, W. (2013). Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury. BMC Surgery, 13, 21. https://doi.org/10.1186/1471-2482-13-21
Su H, et al. Ventral Root Re-implantation Is Better Than Peripheral Nerve Transplantation for Motoneuron Survival and Regeneration After Spinal Root Avulsion Injury. BMC Surg. 2013 Jun 24;13:21. PubMed PMID: 23799915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury. AU - Su,Huanxing, AU - Yuan,Qiuju, AU - Qin,Dajiang, AU - Yang,Xiaoying, AU - Wong,Wai-Man, AU - So,Kwok-Fai, AU - Wu,Wutian, Y1 - 2013/06/24/ PY - 2013/02/24/received PY - 2013/06/19/accepted PY - 2013/6/27/entrez PY - 2013/6/27/pubmed PY - 2015/1/1/medline SP - 21 EP - 21 JF - BMC surgery JO - BMC Surg VL - 13 N2 - BACKGROUND: Peripheral nerve (PN) transplantation and ventral root implantation are the two common types of recovery operations to restore the connection between motoneurons and their target muscles after brachial plexus injury. Despite experience accumulated over the past decade, fundamental knowledge is still lacking concerning the efficacy of the two microsurgical interventions. METHODS: Thirty-eight adult female Sprague-Dawley rats were divided into 5 groups. Immediately following root avulsion, animals in the first group (n = 8) and the second group (n = 8) received PN graft and ventral root implantation respectively. The third group (n = 8) and the fourth group (n = 8) received PN graft and ventral root implantation respectively at one week after root avulsion. The fifth group received root avulsion only as control (n = 6). The survival and axonal regeneration of severed motoneurons were investigated at 6 weeks post-implantation. RESULTS: Re-implantation of ventral roots, both immediately after root avulsion and in delay, significantly increased the survival and regeneration of motoneurons in the avulsed segment of the spinal cord as compared with PN graft transplantation. CONCLUSIONS: The ventral root re-implantation is a better surgical repairing procedure than PN graft transplantation for brachial plexus injury because of its easier manipulation for re-implanting avulsed ventral roots to the preferred site, less possibility of causing additional damage and better effects on motoneuron survival and axonal regeneration. SN - 1471-2482 UR - https://www.unboundmedicine.com/medline/citation/23799915/Ventral_root_re_implantation_is_better_than_peripheral_nerve_transplantation_for_motoneuron_survival_and_regeneration_after_spinal_root_avulsion_injury_ L2 - https://bmcsurg.biomedcentral.com/articles/10.1186/1471-2482-13-21 DB - PRIME DP - Unbound Medicine ER -