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Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis.

Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of childbearing age. The risk of pregnancy and neonatal complications in women with PCOS is debatable. In order to determine the risk of pregnancy and neonatal complications, evidence regarding these risks was examined.

METHODS

Literature searches were performed in the electronic databases MEDLINE, EMBASE, and CENTRAL based on the established strategy and eligible tries were included according to inclusion and exclusion criteria. A systematic literature review looking at rates of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preeclampsia, premature delivery, neonatal birth weight, caesarean section and admission to a neonatal intensive care unit (NICU) was conducted in women with PCOS. Pregnancy outcomes between women with PCOS versus controls were included. Sensitivity analyses were performed to determine the reliability of the available evidence and to validate the results. The study was performed with the approval of the ethics committee of the First Affiliated Hospital of Guangxi Medical University.

RESULTS

A total of 27studies, involving 4982 women with PCOS and 119692 controls were eligible for the meta-analysis. Women with PCOS demonstrated a significantly higher risk of developing GDM (OR3.43; 95% CI: 2.49-4.74), PIH (OR3.43; 95% CI: 2.49-4.74), preeclampsia (OR2.17; 95% CI: 1.91-2.46), preterm birth (OR1.93; 95%CI: 1.45-2.57), caesarean section (OR 1.74; 95% CI: 1.38-2.11) compared to controls. Their babies had a marginally significant lower birth weight (WMD -0.11g; 95%CI: -0.19 - -0.03), and higher risk of admission to NICU (OR 2.32; 95% CI: 1.40-3.85) compared to controls.

CONCLUSIONS

Women with PCOS have increased risk of adverse pregnancy and neonatal complications. It is necessary to establish guidelines for supervision during pregnancy and parturition to prevent these complications.

Authors+Show Affiliations

Department of Prenatal Diagnosis Center, First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

23800002

Citation

Qin, Jun Z., et al. "Obstetric Complications in Women With Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis." Reproductive Biology and Endocrinology : RB&E, vol. 11, 2013, p. 56.
Qin JZ, Pang LH, Li MJ, et al. Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis. Reprod Biol Endocrinol. 2013;11:56.
Qin, J. Z., Pang, L. H., Li, M. J., Fan, X. J., Huang, R. D., & Chen, H. Y. (2013). Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis. Reproductive Biology and Endocrinology : RB&E, 11, p. 56. doi:10.1186/1477-7827-11-56.
Qin JZ, et al. Obstetric Complications in Women With Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis. Reprod Biol Endocrinol. 2013 Jun 26;11:56. PubMed PMID: 23800002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis. AU - Qin,Jun Z, AU - Pang,Li H, AU - Li,Mu J, AU - Fan,Xiao J, AU - Huang,Ru D, AU - Chen,Hong Y, Y1 - 2013/06/26/ PY - 2013/04/08/received PY - 2013/06/13/accepted PY - 2013/6/27/entrez PY - 2013/6/27/pubmed PY - 2013/9/27/medline SP - 56 EP - 56 JF - Reproductive biology and endocrinology : RB&E JO - Reprod. Biol. Endocrinol. VL - 11 N2 - BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of childbearing age. The risk of pregnancy and neonatal complications in women with PCOS is debatable. In order to determine the risk of pregnancy and neonatal complications, evidence regarding these risks was examined. METHODS: Literature searches were performed in the electronic databases MEDLINE, EMBASE, and CENTRAL based on the established strategy and eligible tries were included according to inclusion and exclusion criteria. A systematic literature review looking at rates of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preeclampsia, premature delivery, neonatal birth weight, caesarean section and admission to a neonatal intensive care unit (NICU) was conducted in women with PCOS. Pregnancy outcomes between women with PCOS versus controls were included. Sensitivity analyses were performed to determine the reliability of the available evidence and to validate the results. The study was performed with the approval of the ethics committee of the First Affiliated Hospital of Guangxi Medical University. RESULTS: A total of 27studies, involving 4982 women with PCOS and 119692 controls were eligible for the meta-analysis. Women with PCOS demonstrated a significantly higher risk of developing GDM (OR3.43; 95% CI: 2.49-4.74), PIH (OR3.43; 95% CI: 2.49-4.74), preeclampsia (OR2.17; 95% CI: 1.91-2.46), preterm birth (OR1.93; 95%CI: 1.45-2.57), caesarean section (OR 1.74; 95% CI: 1.38-2.11) compared to controls. Their babies had a marginally significant lower birth weight (WMD -0.11g; 95%CI: -0.19 - -0.03), and higher risk of admission to NICU (OR 2.32; 95% CI: 1.40-3.85) compared to controls. CONCLUSIONS: Women with PCOS have increased risk of adverse pregnancy and neonatal complications. It is necessary to establish guidelines for supervision during pregnancy and parturition to prevent these complications. SN - 1477-7827 UR - https://www.unboundmedicine.com/medline/citation/23800002/Obstetric_complications_in_women_with_polycystic_ovary_syndrome:_a_systematic_review_and_meta_analysis_ L2 - https://rbej.biomedcentral.com/articles/10.1186/1477-7827-11-56 DB - PRIME DP - Unbound Medicine ER -