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Dysregulation of angiopoietin 1 and 2 in Escherichia coli O157:H7 infection and the hemolytic-uremic syndrome.
J Infect Dis. 2013 Sep; 208(6):929-33.JI

Abstract

Escherichia coli O157:H7-associated hemolytic-uremic syndrome (HUS) is characterized by profound prothrombotic abnormalities. Endothelial dysfunction, manifested as dysregulation of angiopoietins 1 and 2 (Ang-1/2), could underlie HUS pathophysiology. We measured Ang-1/2 in 77 children with E. coli O157:H7 infection. Ang-1, Ang-2, and the Ang-2/Ang-1 ratio were significantly different in HUS vs the pre-HUS phase of illness or uncomplicated infection. Angiopoietin dysregulation preceded HUS and worsened as HUS developed. In vitro exposure of human microvascular endothelial cells to Shiga toxin recapitulated the in vivo observations. Angiopoietin regulation is profoundly affected before and during HUS, reflecting that subclinical endothelial dysfunction precedes overt microangiopathy.

Authors+Show Affiliations

Department of Medicine, Sandra A. Rotman, Laboratory for Global Health, Mount Sinai Hospital-University Health Network, University of Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23801605

Citation

Page, Andrea V., et al. "Dysregulation of Angiopoietin 1 and 2 in Escherichia Coli O157:H7 Infection and the Hemolytic-uremic Syndrome." The Journal of Infectious Diseases, vol. 208, no. 6, 2013, pp. 929-33.
Page AV, Tarr PI, Watkins SL, et al. Dysregulation of angiopoietin 1 and 2 in Escherichia coli O157:H7 infection and the hemolytic-uremic syndrome. J Infect Dis. 2013;208(6):929-33.
Page, A. V., Tarr, P. I., Watkins, S. L., Rajwans, N., Petruzziello-Pellegrini, T. N., Marsden, P. A., Kain, K. C., & Liles, W. C. (2013). Dysregulation of angiopoietin 1 and 2 in Escherichia coli O157:H7 infection and the hemolytic-uremic syndrome. The Journal of Infectious Diseases, 208(6), 929-33. https://doi.org/10.1093/infdis/jit268
Page AV, et al. Dysregulation of Angiopoietin 1 and 2 in Escherichia Coli O157:H7 Infection and the Hemolytic-uremic Syndrome. J Infect Dis. 2013;208(6):929-33. PubMed PMID: 23801605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dysregulation of angiopoietin 1 and 2 in Escherichia coli O157:H7 infection and the hemolytic-uremic syndrome. AU - Page,Andrea V, AU - Tarr,Phillip I, AU - Watkins,Sandra L, AU - Rajwans,Nimerta, AU - Petruzziello-Pellegrini,Tania N, AU - Marsden,Philip A, AU - Kain,Kevin C, AU - Liles,W Conrad, Y1 - 2013/06/24/ PY - 2013/6/27/entrez PY - 2013/6/27/pubmed PY - 2013/11/5/medline KW - E. coli O157:H7 KW - angiopoietin 1 KW - angiopoietin 2 KW - endothelial dysfunction KW - hemolytic-uremic syndrome SP - 929 EP - 33 JF - The Journal of infectious diseases JO - J Infect Dis VL - 208 IS - 6 N2 - Escherichia coli O157:H7-associated hemolytic-uremic syndrome (HUS) is characterized by profound prothrombotic abnormalities. Endothelial dysfunction, manifested as dysregulation of angiopoietins 1 and 2 (Ang-1/2), could underlie HUS pathophysiology. We measured Ang-1/2 in 77 children with E. coli O157:H7 infection. Ang-1, Ang-2, and the Ang-2/Ang-1 ratio were significantly different in HUS vs the pre-HUS phase of illness or uncomplicated infection. Angiopoietin dysregulation preceded HUS and worsened as HUS developed. In vitro exposure of human microvascular endothelial cells to Shiga toxin recapitulated the in vivo observations. Angiopoietin regulation is profoundly affected before and during HUS, reflecting that subclinical endothelial dysfunction precedes overt microangiopathy. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/23801605/Dysregulation_of_angiopoietin_1_and_2_in_Escherichia_coli_O157:H7_infection_and_the_hemolytic_uremic_syndrome_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jit268 DB - PRIME DP - Unbound Medicine ER -