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Comparative pharmacokinetics of aloe-emodin, rhein and emodin determined by liquid chromatography-mass spectrometry after oral administration of a rhubarb peony decoction and rhubarb extract to rats.
Pharmazie. 2013 May; 68(5):333-9.P

Abstract

This study aimed to clarify the rationality of herbaceous compatibility of a rhubarb peony decoction (DaHuang-Mu-Dan-Tang, RPD) by comparing the pharmacokinetics of aloe-emodin, rhein and emodin in rats' plasma after oral administration of RPD and rhubarb extract. A rapid, sensitive LC-MS method was developed and validated for the determination of the plasma concentrations of the three analytes after oral administration RPD and rhubarb extract. The developed method was successfully applied to a pharmacokinetic study of aloe-emodin, rhein and emodin in rats' plasma after oral administration. Compared with administration of single rhubarb, the C(max) of rhein in RPD was decreased significantly (p < 0.05). Meanwhile, the T1/2 of aloe-emodin and emodin were increased significantly (p < 0.05) after administration of RPD. In addition, the T(max) of rhein and emodin were also increased significantly (p < 0.05) in RPD. These results indicated that the absorption of rhein in rats was suppressed after oral administration RPD. Moreover, The time for rhein and emodin to reach the peak concentration was delayed and the elimination of aloe-emodin and emodin was also postponed in RPD. This study could provide a meaningful basis for evaluating the clinical application of traditional Chinese medicine in terms of pharmacokinetics.

Authors+Show Affiliations

Zhang YX
College of Pharmacy, Nanjing University of Chinese Medicine Nanjing, China.
Li JS
No affiliation info available
Peng WW
No affiliation info available
Liu X
No affiliation info available
Yang GM
No affiliation info available
Chen LH
No affiliation info available
Cai BC
No affiliation info available

MeSH

AloeAnimalsAnthraquinonesArea Under CurveCalibrationCatharticsChromatography, High Pressure LiquidLinear ModelsMaleMass SpectrometryOrganization and AdministrationPaeoniaPlant ExtractsQuality ControlRatsRats, Sprague-DawleyReference StandardsReproducibility of ResultsRheum

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23802430

Citation

Zhang, Yong-Xin, et al. "Comparative Pharmacokinetics of Aloe-emodin, Rhein and Emodin Determined By Liquid Chromatography-mass Spectrometry After Oral Administration of a Rhubarb Peony Decoction and Rhubarb Extract to Rats." Die Pharmazie, vol. 68, no. 5, 2013, pp. 333-9.
Zhang YX, Li JS, Peng WW, et al. Comparative pharmacokinetics of aloe-emodin, rhein and emodin determined by liquid chromatography-mass spectrometry after oral administration of a rhubarb peony decoction and rhubarb extract to rats. Pharmazie. 2013;68(5):333-9.
Zhang, Y. X., Li, J. S., Peng, W. W., Liu, X., Yang, G. M., Chen, L. H., & Cai, B. C. (2013). Comparative pharmacokinetics of aloe-emodin, rhein and emodin determined by liquid chromatography-mass spectrometry after oral administration of a rhubarb peony decoction and rhubarb extract to rats. Die Pharmazie, 68(5), 333-9.
Zhang YX, et al. Comparative Pharmacokinetics of Aloe-emodin, Rhein and Emodin Determined By Liquid Chromatography-mass Spectrometry After Oral Administration of a Rhubarb Peony Decoction and Rhubarb Extract to Rats. Pharmazie. 2013;68(5):333-9. PubMed PMID: 23802430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative pharmacokinetics of aloe-emodin, rhein and emodin determined by liquid chromatography-mass spectrometry after oral administration of a rhubarb peony decoction and rhubarb extract to rats. AU - Zhang,Yong-Xin, AU - Li,Jun-Song, AU - Peng,Wen-Wen, AU - Liu,Xiao, AU - Yang,Guang-Ming, AU - Chen,Li-Hua, AU - Cai,Bao-Chang, PY - 2013/6/28/entrez PY - 2013/6/28/pubmed PY - 2013/7/26/medline SP - 333 EP - 9 JF - Die Pharmazie JO - Pharmazie VL - 68 IS - 5 N2 - This study aimed to clarify the rationality of herbaceous compatibility of a rhubarb peony decoction (DaHuang-Mu-Dan-Tang, RPD) by comparing the pharmacokinetics of aloe-emodin, rhein and emodin in rats' plasma after oral administration of RPD and rhubarb extract. A rapid, sensitive LC-MS method was developed and validated for the determination of the plasma concentrations of the three analytes after oral administration RPD and rhubarb extract. The developed method was successfully applied to a pharmacokinetic study of aloe-emodin, rhein and emodin in rats' plasma after oral administration. Compared with administration of single rhubarb, the C(max) of rhein in RPD was decreased significantly (p < 0.05). Meanwhile, the T1/2 of aloe-emodin and emodin were increased significantly (p < 0.05) after administration of RPD. In addition, the T(max) of rhein and emodin were also increased significantly (p < 0.05) in RPD. These results indicated that the absorption of rhein in rats was suppressed after oral administration RPD. Moreover, The time for rhein and emodin to reach the peak concentration was delayed and the elimination of aloe-emodin and emodin was also postponed in RPD. This study could provide a meaningful basis for evaluating the clinical application of traditional Chinese medicine in terms of pharmacokinetics. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/23802430/Comparative_pharmacokinetics_of_aloe_emodin_rhein_and_emodin_determined_by_liquid_chromatography_mass_spectrometry_after_oral_administration_of_a_rhubarb_peony_decoction_and_rhubarb_extract_to_rats_ L2 - https://antibodies.cancer.gov/detail/CPTC-GST+Mu1-6 DB - PRIME DP - Unbound Medicine ER -