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Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease.

Abstract

We tested the hypothesis that extracellular haem is linked to the incidence of acute complications of sickle cell disease (SCD). Using multivariable regression analysis, higher plasma free haem, but not total plasma haem, was associated with increased odds of vaso-occlusive crisis (VOC) [P = 0·028, odds ratio (OR); 2·05, 95% Confidence Interval (CI) = 1·08-3·89] and acute chest syndrome (ACS) [P = 0·016, OR; 2·56, CI = 1·19, 5·47], after adjusting for age and gender in children with SCD. These findings suggest that haem and factors that influence its concentration in plasma may be informative of the risk of VOC and ACS in SCD patients.

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  • Authors+Show Affiliations

    ,

    Division of Hematology, Oncology and Bone Marrow Transplantation, Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.

    , , , ,

    Source

    British journal of haematology 162:5 2013 Sep pg 702-5

    MeSH

    Acute Chest Syndrome
    Adolescent
    Anemia, Sickle Cell
    Arterial Occlusive Diseases
    Biomarkers
    Child
    Child, Preschool
    Female
    Heme
    Humans
    Male

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23802701

    Citation

    Adisa, Olufolake A., et al. "Association Between Plasma Free Haem and Incidence of Vaso-occlusive Episodes and Acute Chest Syndrome in Children With Sickle Cell Disease." British Journal of Haematology, vol. 162, no. 5, 2013, pp. 702-5.
    Adisa OA, Hu Y, Ghosh S, et al. Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease. Br J Haematol. 2013;162(5):702-5.
    Adisa, O. A., Hu, Y., Ghosh, S., Aryee, D., Osunkwo, I., & Ofori-Acquah, S. F. (2013). Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease. British Journal of Haematology, 162(5), pp. 702-5. doi:10.1111/bjh.12445.
    Adisa OA, et al. Association Between Plasma Free Haem and Incidence of Vaso-occlusive Episodes and Acute Chest Syndrome in Children With Sickle Cell Disease. Br J Haematol. 2013;162(5):702-5. PubMed PMID: 23802701.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease. AU - Adisa,Olufolake A, AU - Hu,Yijuan, AU - Ghosh,Samit, AU - Aryee,Doreen, AU - Osunkwo,Ifeyinwa, AU - Ofori-Acquah,Solomon F, Y1 - 2013/06/27/ PY - 2013/03/11/received PY - 2013/05/17/accepted PY - 2013/6/28/entrez PY - 2013/6/28/pubmed PY - 2013/10/31/medline KW - acute chest syndrome KW - extracellular haem KW - sickle cell disease KW - vaso-occlusive pain crisis SP - 702 EP - 5 JF - British journal of haematology JO - Br. J. Haematol. VL - 162 IS - 5 N2 - We tested the hypothesis that extracellular haem is linked to the incidence of acute complications of sickle cell disease (SCD). Using multivariable regression analysis, higher plasma free haem, but not total plasma haem, was associated with increased odds of vaso-occlusive crisis (VOC) [P = 0·028, odds ratio (OR); 2·05, 95% Confidence Interval (CI) = 1·08-3·89] and acute chest syndrome (ACS) [P = 0·016, OR; 2·56, CI = 1·19, 5·47], after adjusting for age and gender in children with SCD. These findings suggest that haem and factors that influence its concentration in plasma may be informative of the risk of VOC and ACS in SCD patients. SN - 1365-2141 UR - https://www.unboundmedicine.com/medline/citation/23802701/Association_between_plasma_free_haem_and_incidence_of_vaso_occlusive_episodes_and_acute_chest_syndrome_in_children_with_sickle_cell_disease_ L2 - https://doi.org/10.1111/bjh.12445 DB - PRIME DP - Unbound Medicine ER -