Tags

Type your tag names separated by a space and hit enter

Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease.
Br J Haematol 2013; 162(5):702-5BJ

Abstract

We tested the hypothesis that extracellular haem is linked to the incidence of acute complications of sickle cell disease (SCD). Using multivariable regression analysis, higher plasma free haem, but not total plasma haem, was associated with increased odds of vaso-occlusive crisis (VOC) [P = 0·028, odds ratio (OR); 2·05, 95% Confidence Interval (CI) = 1·08-3·89] and acute chest syndrome (ACS) [P = 0·016, OR; 2·56, CI = 1·19, 5·47], after adjusting for age and gender in children with SCD. These findings suggest that haem and factors that influence its concentration in plasma may be informative of the risk of VOC and ACS in SCD patients.

Authors+Show Affiliations

Division of Hematology, Oncology and Bone Marrow Transplantation, Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23802701

Citation

Adisa, Olufolake A., et al. "Association Between Plasma Free Haem and Incidence of Vaso-occlusive Episodes and Acute Chest Syndrome in Children With Sickle Cell Disease." British Journal of Haematology, vol. 162, no. 5, 2013, pp. 702-5.
Adisa OA, Hu Y, Ghosh S, et al. Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease. Br J Haematol. 2013;162(5):702-5.
Adisa, O. A., Hu, Y., Ghosh, S., Aryee, D., Osunkwo, I., & Ofori-Acquah, S. F. (2013). Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease. British Journal of Haematology, 162(5), pp. 702-5. doi:10.1111/bjh.12445.
Adisa OA, et al. Association Between Plasma Free Haem and Incidence of Vaso-occlusive Episodes and Acute Chest Syndrome in Children With Sickle Cell Disease. Br J Haematol. 2013;162(5):702-5. PubMed PMID: 23802701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease. AU - Adisa,Olufolake A, AU - Hu,Yijuan, AU - Ghosh,Samit, AU - Aryee,Doreen, AU - Osunkwo,Ifeyinwa, AU - Ofori-Acquah,Solomon F, Y1 - 2013/06/27/ PY - 2013/03/11/received PY - 2013/05/17/accepted PY - 2013/6/28/entrez PY - 2013/6/28/pubmed PY - 2013/10/31/medline KW - acute chest syndrome KW - extracellular haem KW - sickle cell disease KW - vaso-occlusive pain crisis SP - 702 EP - 5 JF - British journal of haematology JO - Br. J. Haematol. VL - 162 IS - 5 N2 - We tested the hypothesis that extracellular haem is linked to the incidence of acute complications of sickle cell disease (SCD). Using multivariable regression analysis, higher plasma free haem, but not total plasma haem, was associated with increased odds of vaso-occlusive crisis (VOC) [P = 0·028, odds ratio (OR); 2·05, 95% Confidence Interval (CI) = 1·08-3·89] and acute chest syndrome (ACS) [P = 0·016, OR; 2·56, CI = 1·19, 5·47], after adjusting for age and gender in children with SCD. These findings suggest that haem and factors that influence its concentration in plasma may be informative of the risk of VOC and ACS in SCD patients. SN - 1365-2141 UR - https://www.unboundmedicine.com/medline/citation/23802701/Association_between_plasma_free_haem_and_incidence_of_vaso_occlusive_episodes_and_acute_chest_syndrome_in_children_with_sickle_cell_disease_ L2 - https://doi.org/10.1111/bjh.12445 DB - PRIME DP - Unbound Medicine ER -