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Xanthone glycoside constituents of Swertia kouitchensis with α-glucosidase inhibitory activity.
J Nat Prod. 2013 Jul 26; 76(7):1248-53.JN

Abstract

Ten new xanthone glycosides, kouitchensides A-J (1-10), and 11 known analogues were isolated from an n-butanol fraction of Swertia kouitchensis. The structures of these glycosides were determined on the basis of extensive spectroscopic data interpretation and comparison with data reported in the literature. In an in vitro test, compounds 2, 4, 5, 6, 11, 12, and 13 (IC50 values in the range 126 to 451 μM) displayed more potent inhibitory effects against α-glucosidase activity than the positive control, acarbose (IC50 value of 627 μM).

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wan LS
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Min QX
No affiliation info available
Wang YL
No affiliation info available
Yue YD
No affiliation info available
Chen JC
No affiliation info available

MeSH

1-ButanolDrugs, Chinese HerbalGlycoside Hydrolase InhibitorsGlycosidesInhibitory Concentration 50Molecular StructureNuclear Magnetic Resonance, BiomolecularSaccharomyces cerevisiaeSwertiaXanthones

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23805995

Citation

Wan, Luo-Sheng, et al. "Xanthone Glycoside Constituents of Swertia Kouitchensis With Α-glucosidase Inhibitory Activity." Journal of Natural Products, vol. 76, no. 7, 2013, pp. 1248-53.
Wan LS, Min QX, Wang YL, et al. Xanthone glycoside constituents of Swertia kouitchensis with α-glucosidase inhibitory activity. J Nat Prod. 2013;76(7):1248-53.
Wan, L. S., Min, Q. X., Wang, Y. L., Yue, Y. D., & Chen, J. C. (2013). Xanthone glycoside constituents of Swertia kouitchensis with α-glucosidase inhibitory activity. Journal of Natural Products, 76(7), 1248-53. https://doi.org/10.1021/np400082g
Wan LS, et al. Xanthone Glycoside Constituents of Swertia Kouitchensis With Α-glucosidase Inhibitory Activity. J Nat Prod. 2013 Jul 26;76(7):1248-53. PubMed PMID: 23805995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xanthone glycoside constituents of Swertia kouitchensis with α-glucosidase inhibitory activity. AU - Wan,Luo-Sheng, AU - Min,Qiu-Xia, AU - Wang,Yong-Long, AU - Yue,Yao-Dong, AU - Chen,Jia-Chun, Y1 - 2013/06/27/ PY - 2013/6/29/entrez PY - 2013/6/29/pubmed PY - 2013/11/10/medline SP - 1248 EP - 53 JF - Journal of natural products JO - J Nat Prod VL - 76 IS - 7 N2 - Ten new xanthone glycosides, kouitchensides A-J (1-10), and 11 known analogues were isolated from an n-butanol fraction of Swertia kouitchensis. The structures of these glycosides were determined on the basis of extensive spectroscopic data interpretation and comparison with data reported in the literature. In an in vitro test, compounds 2, 4, 5, 6, 11, 12, and 13 (IC50 values in the range 126 to 451 μM) displayed more potent inhibitory effects against α-glucosidase activity than the positive control, acarbose (IC50 value of 627 μM). SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/23805995/Xanthone_glycoside_constituents_of_Swertia_kouitchensis_with_α_glucosidase_inhibitory_activity_ L2 - https://doi.org/10.1021/np400082g DB - PRIME DP - Unbound Medicine ER -