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Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats.
Biochimie. 2013 Oct; 95(10):1848-54.B

Abstract

Epidemiological studies have demonstrated that the diabetes mellitus is a serious health burden for both governments and healthcare providers. The present study was hypothesized to evaluate the antihyperglycemic potential of fraxetin by determining the activities of key enzymes of carbohydrate metabolism in streptozotocin (STZ) - induced diabetic rats. Diabetes was induced in male albino Wistar rats by intraperitoneal administration of STZ (40 mg/kg b.w). Fraxetin was administered to diabetic rats intra gastrically at 20, 40, 80 mg/kg b.w for 30 days. The dose 80 mg/kg b.w, significantly reduced the levels of blood glucose and glycosylated hemoglobin (HbA1c) and increased plasma insulin level. The altered activities of the key enzymes of carbohydrate metabolism such as glucokinase, glucose-6-phosphate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase and hepatic enzymes (aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP)) in the liver tissues of diabetic rats were significantly reverted to near normal levels by the administration of fraxetin. Further, fraxetin administration to diabetic rats improved body weight and hepatic glycogen content demonstrated its antihyperglycemic potential. The present findings suggest that fraxetin may be useful in the treatment of diabetes even though clinical studies to evaluate this possibility may be warranted.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23806420

Citation

Murali, Raju, et al. "Antihyperglycemic Effect of Fraxetin On Hepatic Key Enzymes of Carbohydrate Metabolism in Streptozotocin-induced Diabetic Rats." Biochimie, vol. 95, no. 10, 2013, pp. 1848-54.
Murali R, Srinivasan S, Ashokkumar N. Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Biochimie. 2013;95(10):1848-54.
Murali, R., Srinivasan, S., & Ashokkumar, N. (2013). Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Biochimie, 95(10), 1848-54. https://doi.org/10.1016/j.biochi.2013.06.013
Murali R, Srinivasan S, Ashokkumar N. Antihyperglycemic Effect of Fraxetin On Hepatic Key Enzymes of Carbohydrate Metabolism in Streptozotocin-induced Diabetic Rats. Biochimie. 2013;95(10):1848-54. PubMed PMID: 23806420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. AU - Murali,Raju, AU - Srinivasan,Subramani, AU - Ashokkumar,Natarajan, Y1 - 2013/06/25/ PY - 2012/12/15/received PY - 2013/06/12/accepted PY - 2013/6/29/entrez PY - 2013/6/29/pubmed PY - 2014/3/13/medline KW - Diabetes mellitus KW - Fraxetin KW - Glucose KW - Streptozotocin SP - 1848 EP - 54 JF - Biochimie JO - Biochimie VL - 95 IS - 10 N2 - Epidemiological studies have demonstrated that the diabetes mellitus is a serious health burden for both governments and healthcare providers. The present study was hypothesized to evaluate the antihyperglycemic potential of fraxetin by determining the activities of key enzymes of carbohydrate metabolism in streptozotocin (STZ) - induced diabetic rats. Diabetes was induced in male albino Wistar rats by intraperitoneal administration of STZ (40 mg/kg b.w). Fraxetin was administered to diabetic rats intra gastrically at 20, 40, 80 mg/kg b.w for 30 days. The dose 80 mg/kg b.w, significantly reduced the levels of blood glucose and glycosylated hemoglobin (HbA1c) and increased plasma insulin level. The altered activities of the key enzymes of carbohydrate metabolism such as glucokinase, glucose-6-phosphate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase and hepatic enzymes (aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP)) in the liver tissues of diabetic rats were significantly reverted to near normal levels by the administration of fraxetin. Further, fraxetin administration to diabetic rats improved body weight and hepatic glycogen content demonstrated its antihyperglycemic potential. The present findings suggest that fraxetin may be useful in the treatment of diabetes even though clinical studies to evaluate this possibility may be warranted. SN - 1638-6183 UR - https://www.unboundmedicine.com/medline/citation/23806420/Antihyperglycemic_effect_of_fraxetin_on_hepatic_key_enzymes_of_carbohydrate_metabolism_in_streptozotocin_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-9084(13)00193-4 DB - PRIME DP - Unbound Medicine ER -