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Fibroblast growth factor receptor 1 (FGFR1) copy number is an independent prognostic factor in non-small cell lung cancer.
Lung Cancer. 2013 Sep; 81(3):462-467.LC

Abstract

Fibroblast growth factor receptor 1 (FGFR1) is an oncogene that can potentially be targeted by tyrosine kinase inhibitors. We aimed to investigate the prevalence and prognostic significance of alterations in FGFR1 copy number in non-small cell lung cancer (NSCLC). FGFR1 status was evaluated by chromogenic silver in situ hybridisation (ISH) in tissue microarray sections from a retrospective cohort of 304 surgically resected NSCLCs and results were correlated with the clinicopathological features and overall survival. High FGFR1 gene copy number (amplification or high-level polysomy) was significantly more frequent in squamous cell carcinomas (SCC) (24.8%) and large cell carcinomas (LCC) (25%) compared to adenocarcinomas (11.3%) (p = 0.01 and p = 0.03 respectively). Among NSCLC there was no significant correlation between FGFR1-positive status and other clinicopathological features including age, gender, smoking history, tumour size, lymph node status, stage, grade, vascular, lymphatic or perineural invasion. FGFR1-positive patients showed a tendency to longer overall survival in univariate analysis (p = 0.14). Multivariate survival analysis using Cox regression model confirmed FGFR1-positive patients had a significant reduction in the risk of death compared to FGFR1-negative patients (HR 0.6; p = 0.02). High FGFR1 gene copy number is a common finding in SCC and LCC and is an independent favourable prognostic factor.

Authors+Show Affiliations

Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.Kinghorn Cancer Centre and Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia; School of Medicine, University of Western Sydney, New South Wales, Australia; St Vincent's Clinical School, University of NSW, New South Wales, Australia.Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia; Sydney Medical School, University of Sydney, New South Wales, Australia.Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia; Kinghorn Cancer Centre and Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia; Sydney Medical School, University of Sydney, New South Wales, Australia.Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia; School of Medicine, University of Western Sydney, New South Wales, Australia. Electronic address: Wendy.Cooper@sswahs.nsw.gov.au.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23806793

Citation

Tran, Thang N., et al. "Fibroblast Growth Factor Receptor 1 (FGFR1) Copy Number Is an Independent Prognostic Factor in Non-small Cell Lung Cancer." Lung Cancer (Amsterdam, Netherlands), vol. 81, no. 3, 2013, pp. 462-467.
Tran TN, Selinger CI, Kohonen-Corish MRJ, et al. Fibroblast growth factor receptor 1 (FGFR1) copy number is an independent prognostic factor in non-small cell lung cancer. Lung Cancer. 2013;81(3):462-467.
Tran, T. N., Selinger, C. I., Kohonen-Corish, M. R. J., McCaughan, B. C., Kennedy, C. W., O'Toole, S. A., & Cooper, W. A. (2013). Fibroblast growth factor receptor 1 (FGFR1) copy number is an independent prognostic factor in non-small cell lung cancer. Lung Cancer (Amsterdam, Netherlands), 81(3), 462-467. https://doi.org/10.1016/j.lungcan.2013.05.015
Tran TN, et al. Fibroblast Growth Factor Receptor 1 (FGFR1) Copy Number Is an Independent Prognostic Factor in Non-small Cell Lung Cancer. Lung Cancer. 2013;81(3):462-467. PubMed PMID: 23806793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibroblast growth factor receptor 1 (FGFR1) copy number is an independent prognostic factor in non-small cell lung cancer. AU - Tran,Thang N, AU - Selinger,Christina I, AU - Kohonen-Corish,Maija R J, AU - McCaughan,Brian C, AU - Kennedy,Catherine W, AU - O'Toole,Sandra A, AU - Cooper,Wendy A, Y1 - 2013/06/24/ PY - 2013/03/07/received PY - 2013/05/03/revised PY - 2013/05/27/accepted PY - 2013/6/29/entrez PY - 2013/6/29/pubmed PY - 2014/4/9/medline KW - Amplification KW - Chromogenic silver in situ hybridisation KW - FGFR1 KW - Fibroblast growth factor receptor KW - Lung cancer KW - NSCLC KW - Squamous cell carcinoma SP - 462 EP - 467 JF - Lung cancer (Amsterdam, Netherlands) JO - Lung Cancer VL - 81 IS - 3 N2 - Fibroblast growth factor receptor 1 (FGFR1) is an oncogene that can potentially be targeted by tyrosine kinase inhibitors. We aimed to investigate the prevalence and prognostic significance of alterations in FGFR1 copy number in non-small cell lung cancer (NSCLC). FGFR1 status was evaluated by chromogenic silver in situ hybridisation (ISH) in tissue microarray sections from a retrospective cohort of 304 surgically resected NSCLCs and results were correlated with the clinicopathological features and overall survival. High FGFR1 gene copy number (amplification or high-level polysomy) was significantly more frequent in squamous cell carcinomas (SCC) (24.8%) and large cell carcinomas (LCC) (25%) compared to adenocarcinomas (11.3%) (p = 0.01 and p = 0.03 respectively). Among NSCLC there was no significant correlation between FGFR1-positive status and other clinicopathological features including age, gender, smoking history, tumour size, lymph node status, stage, grade, vascular, lymphatic or perineural invasion. FGFR1-positive patients showed a tendency to longer overall survival in univariate analysis (p = 0.14). Multivariate survival analysis using Cox regression model confirmed FGFR1-positive patients had a significant reduction in the risk of death compared to FGFR1-negative patients (HR 0.6; p = 0.02). High FGFR1 gene copy number is a common finding in SCC and LCC and is an independent favourable prognostic factor. SN - 1872-8332 UR - https://www.unboundmedicine.com/medline/citation/23806793/Fibroblast_growth_factor_receptor_1__FGFR1__copy_number_is_an_independent_prognostic_factor_in_non_small_cell_lung_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0169-5002(13)00247-X DB - PRIME DP - Unbound Medicine ER -