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Determination of organophosphorus pesticides and metabolites in cereal-based baby foods and wheat flour by means of ultrasound-assisted extraction and hollow-fiber liquid-phase microextraction prior to gas chromatography with nitrogen phosphorus detection.
J Chromatogr A. 2013 Oct 25; 1313:166-74.JC

Abstract

A new method based on hollow-fiber liquid-phase microextraction (HF-LPME) has been developed for the determination of a group of organophosphorus pesticides, including some of their metabolites, in two commercial cereal-based baby foods and one wheat flour prior to gas chromatography-nitrogen phosphorus detection. Samples were first extracted by ultrasound-assisted extraction with acetonitrile (ACN) containing 1.25% (v/v) of formic acid. After evaporation and reconstitution in Milli-Q water, the HF-LPME procedure, using 1-octanol as extraction solvent, was applied followed by a desorption step in ACN, which clearly improved the performance of the technique. The effects of sample pH, ionic strength, stirring rate, extraction temperature and time as well as the desorption procedure were investigated. Under the optimum conditions that involved the extraction of the analytes from 10 mL of the water reconstituted extract at pH 7.0 containing 5% (w/v) of NaCl for 45 min at 960 rpm, the method was validated in terms of linearity, precision and accuracy. The limits of detection (LODs) were between 0.29 and 3.20 μg/kg. The extraction of Milli-Q water, as an example of the applicability of the procedure to aqueous samples, allowed achieving LODs in the range 0.01-0.04 μg/L. Such values, together with the ones achieved for the rest of the samples, are below or equal to the maximum residue limits specified by the European Union.

Authors+Show Affiliations

Departamento de Química Analítica, Nutrición y Bromatología, Facultad de Química, Universidad de La Laguna (ULL), Avenida Astrofísico Francisco Sánchez, s/n° 38206 La Laguna, Tenerife, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23809845

Citation

González-Curbelo, Miguel Ángel, et al. "Determination of Organophosphorus Pesticides and Metabolites in Cereal-based Baby Foods and Wheat Flour By Means of Ultrasound-assisted Extraction and Hollow-fiber Liquid-phase Microextraction Prior to Gas Chromatography With Nitrogen Phosphorus Detection." Journal of Chromatography. A, vol. 1313, 2013, pp. 166-74.
González-Curbelo MÁ, Hernández-Borges J, Borges-Miquel TM, et al. Determination of organophosphorus pesticides and metabolites in cereal-based baby foods and wheat flour by means of ultrasound-assisted extraction and hollow-fiber liquid-phase microextraction prior to gas chromatography with nitrogen phosphorus detection. J Chromatogr A. 2013;1313:166-74.
González-Curbelo, M. Á., Hernández-Borges, J., Borges-Miquel, T. M., & Rodríguez-Delgado, M. Á. (2013). Determination of organophosphorus pesticides and metabolites in cereal-based baby foods and wheat flour by means of ultrasound-assisted extraction and hollow-fiber liquid-phase microextraction prior to gas chromatography with nitrogen phosphorus detection. Journal of Chromatography. A, 1313, 166-74. https://doi.org/10.1016/j.chroma.2013.05.081
González-Curbelo MÁ, et al. Determination of Organophosphorus Pesticides and Metabolites in Cereal-based Baby Foods and Wheat Flour By Means of Ultrasound-assisted Extraction and Hollow-fiber Liquid-phase Microextraction Prior to Gas Chromatography With Nitrogen Phosphorus Detection. J Chromatogr A. 2013 Oct 25;1313:166-74. PubMed PMID: 23809845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of organophosphorus pesticides and metabolites in cereal-based baby foods and wheat flour by means of ultrasound-assisted extraction and hollow-fiber liquid-phase microextraction prior to gas chromatography with nitrogen phosphorus detection. AU - González-Curbelo,Miguel Ángel, AU - Hernández-Borges,Javier, AU - Borges-Miquel,Teresa María, AU - Rodríguez-Delgado,Miguel Ángel, Y1 - 2013/06/10/ PY - 2013/03/21/received PY - 2013/05/24/revised PY - 2013/05/27/accepted PY - 2013/7/2/entrez PY - 2013/7/3/pubmed PY - 2014/3/13/medline KW - Cereal-based baby foods KW - Gas chromatography-nitrogen phosphorus detection KW - Hollow-fiber liquid-phase microextraction KW - Organophosphorus pesticides KW - Ultrasound-assisted extraction KW - Wheat flour SP - 166 EP - 74 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1313 N2 - A new method based on hollow-fiber liquid-phase microextraction (HF-LPME) has been developed for the determination of a group of organophosphorus pesticides, including some of their metabolites, in two commercial cereal-based baby foods and one wheat flour prior to gas chromatography-nitrogen phosphorus detection. Samples were first extracted by ultrasound-assisted extraction with acetonitrile (ACN) containing 1.25% (v/v) of formic acid. After evaporation and reconstitution in Milli-Q water, the HF-LPME procedure, using 1-octanol as extraction solvent, was applied followed by a desorption step in ACN, which clearly improved the performance of the technique. The effects of sample pH, ionic strength, stirring rate, extraction temperature and time as well as the desorption procedure were investigated. Under the optimum conditions that involved the extraction of the analytes from 10 mL of the water reconstituted extract at pH 7.0 containing 5% (w/v) of NaCl for 45 min at 960 rpm, the method was validated in terms of linearity, precision and accuracy. The limits of detection (LODs) were between 0.29 and 3.20 μg/kg. The extraction of Milli-Q water, as an example of the applicability of the procedure to aqueous samples, allowed achieving LODs in the range 0.01-0.04 μg/L. Such values, together with the ones achieved for the rest of the samples, are below or equal to the maximum residue limits specified by the European Union. SN - 1873-3778 UR - https://www.unboundmedicine.com/medline/citation/23809845/Determination_of_organophosphorus_pesticides_and_metabolites_in_cereal_based_baby_foods_and_wheat_flour_by_means_of_ultrasound_assisted_extraction_and_hollow_fiber_liquid_phase_microextraction_prior_to_gas_chromatography_with_nitrogen_phosphorus_detection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(13)00878-9 DB - PRIME DP - Unbound Medicine ER -