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Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats.
Auton Neurosci. 2013 Dec; 179(1-2):9-13.AN

Abstract

Polyphenols consumption detected in red wine and grape juice may prevent or help in the treatment of hypertension. However, cardiovascular autonomic effects of polyphenols were poorly studied. Therefore, we evaluated the effects of resveratrol and grape juice treatments in hemodynamics, baroreflex sensitivity, heart rate (HR) and blood pressure (BP) variability and cardiac redox parameters. Male Wistar rats were divided in 3 groups (n=7/each) and treated for 30 days: only L-NAME-treated (60 mg/kg/day by oral gavage), L-NAME+resveratrol (L-NAME+R) and L-NAME+grape juice (L-NAME+G). BP signal was directly recorded and pulse interval (PI) and systolic arterial pressure (SAP) variability were analyzed in time and frequency domains. Baroreflex sensitivity (BRS) was determined by the alpha index. Oxidized and reduced glutathione concentrations were determined in cardiac tissue. L-NAME increased BP with no differences among groups (mean BP: L-NAME=124±4, L-NAME+R=126±3 and L-NAME+G=125±4 mmHg). PI and SAP variability expressed by total variance were also similar among groups. However, normalized low frequency (LF) and high frequency (HF) components of PI variability were lower and higher, respectively, in both R and G-treated groups when compared to only L-NAME group. Interestingly, sympathetic modulation to the vessels (LF from SAP variability) and BRS were decreased and increased, respectively, only in L-NAME+R rats. Additionally, GSH/GSSG ratios were higher in L-NAME+R and L-NAME+G than in L-NAME group. Our results indicate that resveratrol and grape juice treatments can modulate autonomic function and promote cardiac redox benefits even when nitric oxide is decreased. Moreover, resveratrol influences not only cardiac but also vascular autonomic modulation.

Authors+Show Affiliations

Unidade de Pesquisa, Fundação Universitária de Cardiologia, Instituto de Cardiologia, Porto Alegre, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23810687

Citation

Dillenburg, Denise Ruttke, et al. "Resveratrol and Grape Juice Differentially Ameliorate Cardiovascular Autonomic Modulation in L-NAME-treated Rats." Autonomic Neuroscience : Basic & Clinical, vol. 179, no. 1-2, 2013, pp. 9-13.
Dillenburg DR, Mostarda C, Moraes-Silva IC, et al. Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats. Auton Neurosci. 2013;179(1-2):9-13.
Dillenburg, D. R., Mostarda, C., Moraes-Silva, I. C., Ferreira, D., Bós, D. d. a. . S., Duarte, A. A., Irigoyen, M. C., & Rigatto, K. (2013). Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats. Autonomic Neuroscience : Basic & Clinical, 179(1-2), 9-13. https://doi.org/10.1016/j.autneu.2013.06.002
Dillenburg DR, et al. Resveratrol and Grape Juice Differentially Ameliorate Cardiovascular Autonomic Modulation in L-NAME-treated Rats. Auton Neurosci. 2013;179(1-2):9-13. PubMed PMID: 23810687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats. AU - Dillenburg,Denise Ruttke, AU - Mostarda,Cristiano, AU - Moraes-Silva,Ivana Cinthya, AU - Ferreira,Daiane, AU - Bós,Denielli da Silva Gonçalves, AU - Duarte,Ana Amélia Machado, AU - Irigoyen,Maria Cláudia, AU - Rigatto,Katya, Y1 - 2013/06/28/ PY - 2013/01/29/received PY - 2013/06/05/revised PY - 2013/06/10/accepted PY - 2013/7/2/entrez PY - 2013/7/3/pubmed PY - 2014/8/7/medline KW - Autonomic modulation KW - Grape juice KW - L-NAME KW - Resveratrol SP - 9 EP - 13 JF - Autonomic neuroscience : basic & clinical JO - Auton Neurosci VL - 179 IS - 1-2 N2 - Polyphenols consumption detected in red wine and grape juice may prevent or help in the treatment of hypertension. However, cardiovascular autonomic effects of polyphenols were poorly studied. Therefore, we evaluated the effects of resveratrol and grape juice treatments in hemodynamics, baroreflex sensitivity, heart rate (HR) and blood pressure (BP) variability and cardiac redox parameters. Male Wistar rats were divided in 3 groups (n=7/each) and treated for 30 days: only L-NAME-treated (60 mg/kg/day by oral gavage), L-NAME+resveratrol (L-NAME+R) and L-NAME+grape juice (L-NAME+G). BP signal was directly recorded and pulse interval (PI) and systolic arterial pressure (SAP) variability were analyzed in time and frequency domains. Baroreflex sensitivity (BRS) was determined by the alpha index. Oxidized and reduced glutathione concentrations were determined in cardiac tissue. L-NAME increased BP with no differences among groups (mean BP: L-NAME=124±4, L-NAME+R=126±3 and L-NAME+G=125±4 mmHg). PI and SAP variability expressed by total variance were also similar among groups. However, normalized low frequency (LF) and high frequency (HF) components of PI variability were lower and higher, respectively, in both R and G-treated groups when compared to only L-NAME group. Interestingly, sympathetic modulation to the vessels (LF from SAP variability) and BRS were decreased and increased, respectively, only in L-NAME+R rats. Additionally, GSH/GSSG ratios were higher in L-NAME+R and L-NAME+G than in L-NAME group. Our results indicate that resveratrol and grape juice treatments can modulate autonomic function and promote cardiac redox benefits even when nitric oxide is decreased. Moreover, resveratrol influences not only cardiac but also vascular autonomic modulation. SN - 1872-7484 UR - https://www.unboundmedicine.com/medline/citation/23810687/Resveratrol_and_grape_juice_differentially_ameliorate_cardiovascular_autonomic_modulation_in_L_NAME_treated_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(13)00569-9 DB - PRIME DP - Unbound Medicine ER -