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Vascular risk factors: a ticking time bomb to Alzheimer's disease.

Abstract

Evidence is growing that vascular risk factors (VRFs) for Alzheimer's disease (AD) affect cerebral hemodynamics to launch a cascade of cellular and molecular changes that initiate cognitive deficits and eventual progression of AD. Neuroimaging studies have reported VRFs for AD to be accurate predictors of cognitive decline and dementia. In regions that participate in higher cognitive function, middle temporal, posterior cingulate, inferior parietal and precuneus regions, and neuroimaging studies indicate an association involving VRFs, cerebral hypoperfusion, and cognitive decline in elderly individuals who develop AD. The VRF can be present in cognitively intact individuals for decades before mild cognitive deficits or neuropathological signs are manifested. In that sense, they may be "ticking time bombs" before cognitive function is demolished. Preventive intervention of modifiable VRF may delay or block progression of AD. Intervention could target cerebral blood flow (CBF), since most VRFs act to lower CBF in aging individuals by promoting cerebrovascular dysfunction.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Psychology, University of Texas, Austin, TX 78712, USA. jcdelatorre@comcast.net

    Source

    MeSH

    Aged
    Aging
    Alzheimer Disease
    Brain
    Cerebrovascular Circulation
    Cerebrovascular Disorders
    Homeostasis
    Humans
    Risk Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23813612

    Citation

    de la Torre, Jack C.. "Vascular Risk Factors: a Ticking Time Bomb to Alzheimer's Disease." American Journal of Alzheimer's Disease and Other Dementias, vol. 28, no. 6, 2013, pp. 551-9.
    de la Torre JC. Vascular risk factors: a ticking time bomb to Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2013;28(6):551-9.
    de la Torre, J. C. (2013). Vascular risk factors: a ticking time bomb to Alzheimer's disease. American Journal of Alzheimer's Disease and Other Dementias, 28(6), pp. 551-9. doi:10.1177/1533317513494457.
    de la Torre JC. Vascular Risk Factors: a Ticking Time Bomb to Alzheimer's Disease. Am J Alzheimers Dis Other Demen. 2013;28(6):551-9. PubMed PMID: 23813612.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vascular risk factors: a ticking time bomb to Alzheimer's disease. A1 - de la Torre,Jack C, Y1 - 2013/06/28/ PY - 2013/7/2/entrez PY - 2013/7/3/pubmed PY - 2014/4/2/medline KW - Alzheimer’s KW - aging KW - cerebral blood flow KW - hypoperfusion KW - neuroimaging KW - vascular risk factors SP - 551 EP - 9 JF - American journal of Alzheimer's disease and other dementias JO - Am J Alzheimers Dis Other Demen VL - 28 IS - 6 N2 - Evidence is growing that vascular risk factors (VRFs) for Alzheimer's disease (AD) affect cerebral hemodynamics to launch a cascade of cellular and molecular changes that initiate cognitive deficits and eventual progression of AD. Neuroimaging studies have reported VRFs for AD to be accurate predictors of cognitive decline and dementia. In regions that participate in higher cognitive function, middle temporal, posterior cingulate, inferior parietal and precuneus regions, and neuroimaging studies indicate an association involving VRFs, cerebral hypoperfusion, and cognitive decline in elderly individuals who develop AD. The VRF can be present in cognitively intact individuals for decades before mild cognitive deficits or neuropathological signs are manifested. In that sense, they may be "ticking time bombs" before cognitive function is demolished. Preventive intervention of modifiable VRF may delay or block progression of AD. Intervention could target cerebral blood flow (CBF), since most VRFs act to lower CBF in aging individuals by promoting cerebrovascular dysfunction. SN - 1938-2731 UR - https://www.unboundmedicine.com/medline/citation/23813612/Vascular_risk_factors:_a_ticking_time_bomb_to_Alzheimer's_disease_ L2 - http://journals.sagepub.com/doi/full/10.1177/1533317513494457?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -