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Vitamin D supplementation and risk of respiratory tract infections: a meta-analysis of randomized controlled trials.
Scand J Infect Dis. 2013 Sep; 45(9):696-702.SJ

Abstract

BACKGROUND

It is well-documented that serum levels of 25-hydroxyvitamin D (25-OHD) are inversely associated with the risk of respiratory tract infections (RTIs). However, whether or not vitamin D supplementation prevents RTIs remains inconclusive. The aim of this study was to evaluate the role of vitamin D supplementation in preventing RTIs in healthy populations by performing a meta-analysis of randomized controlled trials (RCTs).

METHODS

RCTs regarding the association between vitamin D supplementation and the risk of RTIs were identified by searching PubMed, Embase, and Cochrane databases through January 2013. Reference lists of retrieved articles were also reviewed. Either a fixed-effects or, in the presence of heterogeneity, a random-effects model was used to calculate the pooled preventive effects.

RESULTS

Seven RCTs involving 4827 participants were included in this meta-analysis. The pooled relative risk (RR) for subjects administered with vitamin D compared with control groups was 0.98 (95% confidence interval 0.93-1.03, p = 0.45). Meta-regression analyses showed almost no impact on the RR of age, vitamin D dosing regimen, and length of follow-up. Omission of any single trial had little impact on the pooled risk estimates. No evidence of publication bias was observed.

CONCLUSIONS

Our findings do not support the routine use of vitamin D supplementation for RTI prevention in healthy populations. Larger studies are needed to investigate the effects of vitamin D supplementation on RTI prevention in various populations and to further clarify the influences of age, vitamin D dosing regimen, baseline levels of vitamin D, and study length.

Authors+Show Affiliations

Department of Nephrology, Nanjing Children's Hospital of Nanjing Medical University, Nanjing, China.No affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23815596

Citation

Mao, Song, and Songming Huang. "Vitamin D Supplementation and Risk of Respiratory Tract Infections: a Meta-analysis of Randomized Controlled Trials." Scandinavian Journal of Infectious Diseases, vol. 45, no. 9, 2013, pp. 696-702.
Mao S, Huang S. Vitamin D supplementation and risk of respiratory tract infections: a meta-analysis of randomized controlled trials. Scand J Infect Dis. 2013;45(9):696-702.
Mao, S., & Huang, S. (2013). Vitamin D supplementation and risk of respiratory tract infections: a meta-analysis of randomized controlled trials. Scandinavian Journal of Infectious Diseases, 45(9), 696-702. https://doi.org/10.3109/00365548.2013.803293
Mao S, Huang S. Vitamin D Supplementation and Risk of Respiratory Tract Infections: a Meta-analysis of Randomized Controlled Trials. Scand J Infect Dis. 2013;45(9):696-702. PubMed PMID: 23815596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D supplementation and risk of respiratory tract infections: a meta-analysis of randomized controlled trials. AU - Mao,Song, AU - Huang,Songming, Y1 - 2013/07/02/ PY - 2013/7/3/entrez PY - 2013/7/3/pubmed PY - 2014/5/10/medline SP - 696 EP - 702 JF - Scandinavian journal of infectious diseases JO - Scand. J. Infect. Dis. VL - 45 IS - 9 N2 - BACKGROUND: It is well-documented that serum levels of 25-hydroxyvitamin D (25-OHD) are inversely associated with the risk of respiratory tract infections (RTIs). However, whether or not vitamin D supplementation prevents RTIs remains inconclusive. The aim of this study was to evaluate the role of vitamin D supplementation in preventing RTIs in healthy populations by performing a meta-analysis of randomized controlled trials (RCTs). METHODS: RCTs regarding the association between vitamin D supplementation and the risk of RTIs were identified by searching PubMed, Embase, and Cochrane databases through January 2013. Reference lists of retrieved articles were also reviewed. Either a fixed-effects or, in the presence of heterogeneity, a random-effects model was used to calculate the pooled preventive effects. RESULTS: Seven RCTs involving 4827 participants were included in this meta-analysis. The pooled relative risk (RR) for subjects administered with vitamin D compared with control groups was 0.98 (95% confidence interval 0.93-1.03, p = 0.45). Meta-regression analyses showed almost no impact on the RR of age, vitamin D dosing regimen, and length of follow-up. Omission of any single trial had little impact on the pooled risk estimates. No evidence of publication bias was observed. CONCLUSIONS: Our findings do not support the routine use of vitamin D supplementation for RTI prevention in healthy populations. Larger studies are needed to investigate the effects of vitamin D supplementation on RTI prevention in various populations and to further clarify the influences of age, vitamin D dosing regimen, baseline levels of vitamin D, and study length. SN - 1651-1980 UR - https://www.unboundmedicine.com/medline/citation/23815596/Vitamin_D_supplementation_and_risk_of_respiratory_tract_infections:_a_meta_analysis_of_randomized_controlled_trials_ L2 - http://www.tandfonline.com/doi/full/10.3109/00365548.2013.803293 DB - PRIME DP - Unbound Medicine ER -