Tags

Type your tag names separated by a space and hit enter

A new type of glucose biosensor based on surface acoustic wave resonator using Mn-doped ZnO multilayer structure.
Biosens Bioelectron. 2013 Nov 15; 49:512-8.BB

Abstract

This work reports a high-performance Mn-doped ZnO multilayer structure Love mode surface acoustic wave (SAW) biosensor for the detection of blood sugar. The biosensor was functionalized via immobilizing glucose oxidase onto a pH-sensitive polymer which was attached on Mn-doped ZnO biosensor. The fabricated SAW glucose biosensor is highly sensitive, accurate and fast with good anti-interference. The sensitivity of the SAW glucose biosensor is 7.184 MHz/mM and the accuracy is 6.96 × 10(-3)mM, which is sensitive and accurate enough for glucose monitoring. A good degree of reversibility and stability of the glucose sensor is also demonstrated, which keeps a constant differential frequency shift up to 32 days. Concerning the time response to human serum, the glucose sensor shows a value of 4.6 ± 0.4 min when increasing glucose concentrations and 7.1 ± 0.6 min when decreasing, which is less than 10 min and reach the fast response requirement for medical applications. The Mn-doped ZnO Love mode SAW biosensor can be fully integrated with CMOS Si chips and developed as a portable, passive and wireless real time detection system for blood sugar monitoring in human serum.

Links

Publisher Full Text

Authors+Show Affiliations

Luo J
Institute of Thin Film Physics and Applications, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen 518060, China. luojt@szu.edu.cn
Luo P
No affiliation info available
Xie M
No affiliation info available
Du K
No affiliation info available
Zhao B
No affiliation info available
Pan F
No affiliation info available
Fan P
No affiliation info available
Zeng F
No affiliation info available
Zhang D
No affiliation info available
Zheng Z
No affiliation info available
Liang G
No affiliation info available

MeSH

AnimalsBiosensing TechniquesBlood GlucoseEnzymes, ImmobilizedEquipment DesignGlucose OxidaseHumansManganeseSensitivity and SpecificitySoundZinc Oxide

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23816847

Citation

Luo, Jingting, et al. "A New Type of Glucose Biosensor Based On Surface Acoustic Wave Resonator Using Mn-doped ZnO Multilayer Structure." Biosensors & Bioelectronics, vol. 49, 2013, pp. 512-8.
Luo J, Luo P, Xie M, et al. A new type of glucose biosensor based on surface acoustic wave resonator using Mn-doped ZnO multilayer structure. Biosens Bioelectron. 2013;49:512-8.
Luo, J., Luo, P., Xie, M., Du, K., Zhao, B., Pan, F., Fan, P., Zeng, F., Zhang, D., Zheng, Z., & Liang, G. (2013). A new type of glucose biosensor based on surface acoustic wave resonator using Mn-doped ZnO multilayer structure. Biosensors & Bioelectronics, 49, 512-8. https://doi.org/10.1016/j.bios.2013.05.021
Luo J, et al. A New Type of Glucose Biosensor Based On Surface Acoustic Wave Resonator Using Mn-doped ZnO Multilayer Structure. Biosens Bioelectron. 2013 Nov 15;49:512-8. PubMed PMID: 23816847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new type of glucose biosensor based on surface acoustic wave resonator using Mn-doped ZnO multilayer structure. AU - Luo,Jingting, AU - Luo,Pingxiang, AU - Xie,Min, AU - Du,Ke, AU - Zhao,Bixia, AU - Pan,Feng, AU - Fan,Ping, AU - Zeng,Fei, AU - Zhang,Dongping, AU - Zheng,Zhuanghao, AU - Liang,Guangxing, Y1 - 2013/06/12/ PY - 2013/02/27/received PY - 2013/04/28/revised PY - 2013/05/20/accepted PY - 2013/7/3/entrez PY - 2013/7/3/pubmed PY - 2014/2/14/medline KW - Biosensor KW - Glucose KW - Glucose oxidase functional immobilization KW - Surface acoustic wave (SAW) KW - ZnO SP - 512 EP - 8 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 49 N2 - This work reports a high-performance Mn-doped ZnO multilayer structure Love mode surface acoustic wave (SAW) biosensor for the detection of blood sugar. The biosensor was functionalized via immobilizing glucose oxidase onto a pH-sensitive polymer which was attached on Mn-doped ZnO biosensor. The fabricated SAW glucose biosensor is highly sensitive, accurate and fast with good anti-interference. The sensitivity of the SAW glucose biosensor is 7.184 MHz/mM and the accuracy is 6.96 × 10(-3)mM, which is sensitive and accurate enough for glucose monitoring. A good degree of reversibility and stability of the glucose sensor is also demonstrated, which keeps a constant differential frequency shift up to 32 days. Concerning the time response to human serum, the glucose sensor shows a value of 4.6 ± 0.4 min when increasing glucose concentrations and 7.1 ± 0.6 min when decreasing, which is less than 10 min and reach the fast response requirement for medical applications. The Mn-doped ZnO Love mode SAW biosensor can be fully integrated with CMOS Si chips and developed as a portable, passive and wireless real time detection system for blood sugar monitoring in human serum. SN - 1873-4235 UR - https://www.unboundmedicine.com/medline/citation/23816847/A_new_type_of_glucose_biosensor_based_on_surface_acoustic_wave_resonator_using_Mn_doped_ZnO_multilayer_structure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(13)00345-X DB - PRIME DP - Unbound Medicine ER -