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Cytotoxic, antioxidant, antimicrobial properties and chemical composition of rose petals.
J Sci Food Agric. 2014 Feb; 94(3):560-7.JS

Abstract

BACKGROUND

Rosa rugosa petals are used for production of teas, jams, wines and juices. Despite the wide availability of rose cultivars, comprehensive information on petal chemical composition and healthful properties is still lacking. Therefore, the aim of this study was analysis of cytotoxic, antioxidant and antimicrobial activity and chemical composition of rugosa rose petals.

RESULTS

Petals of R. rugosa were evaluated for their cytotoxic effect against cervical (HeLa) and breast cancer (T47D) cell lines and for antiradical activity (with DPPH•). As a result, significant cytotoxic (up to 100% of dead cells) and antiradical properties (IC₅₀ 1.33-0.08 mg mg⁻¹ DPPH•) were demonstrated. Moreover, notable antimicrobial activity against eight bacterial (i.e. Staphylococcus. epidermidis, S. aureus, Bacillus subtilis, Micrococcus luteus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis) and two yeast strains (Candida. albicans, C. parapsilosis) was shown. Total phenolic, flavonoid, phenolic acid, tannin, carotenoid and polysaccharide content in petals was determined using spectrophotometric methods. Liquid chromatography-electrospray ionization-tandem mass spectrometry was used to thoroughly analyze phenolic acids and flavonoid glycosides in the methanolic extract and fractions obtained after its separation. Five phenolic acids and six flavonoids previously not reported in the plant material were identified.

CONCLUSION

This is the first such detailed report on chemical composition and biological activity of R. rugosa petals.

Authors+Show Affiliations

Department of Pharmaceutical Botany, Medical University, 20-093, Lublin, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23818393

Citation

Nowak, Renata, et al. "Cytotoxic, Antioxidant, Antimicrobial Properties and Chemical Composition of Rose Petals." Journal of the Science of Food and Agriculture, vol. 94, no. 3, 2014, pp. 560-7.
Nowak R, Olech M, Pecio L, et al. Cytotoxic, antioxidant, antimicrobial properties and chemical composition of rose petals. J Sci Food Agric. 2014;94(3):560-7.
Nowak, R., Olech, M., Pecio, L., Oleszek, W., Los, R., Malm, A., & Rzymowska, J. (2014). Cytotoxic, antioxidant, antimicrobial properties and chemical composition of rose petals. Journal of the Science of Food and Agriculture, 94(3), 560-7. https://doi.org/10.1002/jsfa.6294
Nowak R, et al. Cytotoxic, Antioxidant, Antimicrobial Properties and Chemical Composition of Rose Petals. J Sci Food Agric. 2014;94(3):560-7. PubMed PMID: 23818393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic, antioxidant, antimicrobial properties and chemical composition of rose petals. AU - Nowak,Renata, AU - Olech,Marta, AU - Pecio,Lukasz, AU - Oleszek,Wiesław, AU - Los,Renata, AU - Malm,Anna, AU - Rzymowska,Jolanta, Y1 - 2013/08/02/ PY - 2013/05/06/received PY - 2013/06/21/revised PY - 2013/07/01/accepted PY - 2013/7/3/entrez PY - 2013/7/3/pubmed PY - 2014/9/13/medline KW - LC-MS KW - Rosa rugosa KW - antibacterial activity KW - cytotoxic effect KW - phenolics KW - radical scavenging activity SP - 560 EP - 7 JF - Journal of the science of food and agriculture JO - J Sci Food Agric VL - 94 IS - 3 N2 - BACKGROUND: Rosa rugosa petals are used for production of teas, jams, wines and juices. Despite the wide availability of rose cultivars, comprehensive information on petal chemical composition and healthful properties is still lacking. Therefore, the aim of this study was analysis of cytotoxic, antioxidant and antimicrobial activity and chemical composition of rugosa rose petals. RESULTS: Petals of R. rugosa were evaluated for their cytotoxic effect against cervical (HeLa) and breast cancer (T47D) cell lines and for antiradical activity (with DPPH•). As a result, significant cytotoxic (up to 100% of dead cells) and antiradical properties (IC₅₀ 1.33-0.08 mg mg⁻¹ DPPH•) were demonstrated. Moreover, notable antimicrobial activity against eight bacterial (i.e. Staphylococcus. epidermidis, S. aureus, Bacillus subtilis, Micrococcus luteus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis) and two yeast strains (Candida. albicans, C. parapsilosis) was shown. Total phenolic, flavonoid, phenolic acid, tannin, carotenoid and polysaccharide content in petals was determined using spectrophotometric methods. Liquid chromatography-electrospray ionization-tandem mass spectrometry was used to thoroughly analyze phenolic acids and flavonoid glycosides in the methanolic extract and fractions obtained after its separation. Five phenolic acids and six flavonoids previously not reported in the plant material were identified. CONCLUSION: This is the first such detailed report on chemical composition and biological activity of R. rugosa petals. SN - 1097-0010 UR - https://www.unboundmedicine.com/medline/citation/23818393/Cytotoxic_antioxidant_antimicrobial_properties_and_chemical_composition_of_rose_petals_ L2 - https://doi.org/10.1002/jsfa.6294 DB - PRIME DP - Unbound Medicine ER -