Saeedi Vahdat, Armin, et al. "Ultrasonic Approach for Viscoelastic and Microstructure Characterization of Granular Pharmaceutical Tablets." International Journal of Pharmaceutics, vol. 454, no. 1, 2013, pp. 333-43.
Saeedi Vahdat A, Krishna Prasad Vallabh C, Hancock BC, et al. Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets. Int J Pharm. 2013;454(1):333-43.
Saeedi Vahdat, A., Krishna Prasad Vallabh, C., Hancock, B. C., & Cetinkaya, C. (2013). Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets. International Journal of Pharmaceutics, 454(1), 333-43. https://doi.org/10.1016/j.ijpharm.2013.06.045
Saeedi Vahdat A, et al. Ultrasonic Approach for Viscoelastic and Microstructure Characterization of Granular Pharmaceutical Tablets. Int J Pharm. 2013 Sep 15;454(1):333-43. PubMed PMID: 23820132.
TY - JOUR
T1 - Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets.
AU - Saeedi Vahdat,Armin,
AU - Krishna Prasad Vallabh,Chaitanya,
AU - Hancock,Bruno C,
AU - Cetinkaya,Cetin,
Y1 - 2013/06/29/
PY - 2013/03/21/received
PY - 2013/06/10/revised
PY - 2013/06/23/accepted
PY - 2013/7/4/entrez
PY - 2013/7/4/pubmed
PY - 2014/2/28/medline
KW - Grain size distribution
KW - Granular pharmaceutical solid dosage
KW - Mechanical properties
KW - Non-destructive characterization techniques
KW - Rayleigh scattering
KW - Viscoelasticity
SP - 333
EP - 43
JF - International journal of pharmaceutics
JO - Int J Pharm
VL - 454
IS - 1
N2 - The mechanical properties of a solid dosage, defined by its granular micro-structure and geometry, play a key role in its dissolution profile and performance. An ultrasonic method for extracting the viscoelastic material properties and granular structure of drug tablet compacts is introduced and its utility is demonstrated for tablet compacts made of microcrystalline cellulose (MCC), lactose monohydrate, and sodium starch glycolate as well as magnesium stearate as lubricant. The approach is based on the effect of viscoelasticity and internal micro-structures on the frequency-dependent attenuation of an ultrasonic wave propagating in a granular medium. The models for viscoelastic (a two-parameter Zener model) and scattering attenuation (Rayleigh model) mechanisms are employed. The material parameters including viscoelastic and scattering parameters (average Young's modulus, stress and strain relaxation time constants, and the Rayleigh scattering material parameter) and grain size distribution with a known distribution profile are extracted by an optimization algorithm based on the least square method. The results also indicate good agreement between experimentally and computationally determined phase and group velocities in compacted samples. It is found that the effects of both attenuation mechanisms are present and the extracted grain size distribution parameters are in good agreement with the optically determined values.
SN - 1873-3476
UR - https://www.unboundmedicine.com/medline/citation/23820132/Ultrasonic_approach_for_viscoelastic_and_microstructure_characterization_of_granular_pharmaceutical_tablets_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(13)00554-1
DB - PRIME
DP - Unbound Medicine