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Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets.
Int J Pharm. 2013 Sep 15; 454(1):333-43.IJ

Abstract

The mechanical properties of a solid dosage, defined by its granular micro-structure and geometry, play a key role in its dissolution profile and performance. An ultrasonic method for extracting the viscoelastic material properties and granular structure of drug tablet compacts is introduced and its utility is demonstrated for tablet compacts made of microcrystalline cellulose (MCC), lactose monohydrate, and sodium starch glycolate as well as magnesium stearate as lubricant. The approach is based on the effect of viscoelasticity and internal micro-structures on the frequency-dependent attenuation of an ultrasonic wave propagating in a granular medium. The models for viscoelastic (a two-parameter Zener model) and scattering attenuation (Rayleigh model) mechanisms are employed. The material parameters including viscoelastic and scattering parameters (average Young's modulus, stress and strain relaxation time constants, and the Rayleigh scattering material parameter) and grain size distribution with a known distribution profile are extracted by an optimization algorithm based on the least square method. The results also indicate good agreement between experimentally and computationally determined phase and group velocities in compacted samples. It is found that the effects of both attenuation mechanisms are present and the extracted grain size distribution parameters are in good agreement with the optically determined values.

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Authors+Show Affiliations

Saeedi Vahdat A
Department of Mechanical and Aeronautical Engineering, Photo-Acoustics Research Laboratory, Center for Advanced Materials Processing, Clarkson University, Potsdam, NY 13699-5725, USA.
Krishna Prasad Vallabh C
No affiliation info available
Hancock BC
No affiliation info available
Cetinkaya C
No affiliation info available

MeSH

AlgorithmsCelluloseChemistry, PharmaceuticalElastic ModulusElasticityExcipientsLactoseLeast-Squares AnalysisLubricantsModels, ChemicalMolecular StructureParticle SizeScattering, RadiationStarchStearic AcidsStress, MechanicalTabletsTechnology, PharmaceuticalTransducersUltrasonicsViscosity

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23820132

Citation

Saeedi Vahdat, Armin, et al. "Ultrasonic Approach for Viscoelastic and Microstructure Characterization of Granular Pharmaceutical Tablets." International Journal of Pharmaceutics, vol. 454, no. 1, 2013, pp. 333-43.
Saeedi Vahdat A, Krishna Prasad Vallabh C, Hancock BC, et al. Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets. Int J Pharm. 2013;454(1):333-43.
Saeedi Vahdat, A., Krishna Prasad Vallabh, C., Hancock, B. C., & Cetinkaya, C. (2013). Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets. International Journal of Pharmaceutics, 454(1), 333-43. https://doi.org/10.1016/j.ijpharm.2013.06.045
Saeedi Vahdat A, et al. Ultrasonic Approach for Viscoelastic and Microstructure Characterization of Granular Pharmaceutical Tablets. Int J Pharm. 2013 Sep 15;454(1):333-43. PubMed PMID: 23820132.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets. AU - Saeedi Vahdat,Armin, AU - Krishna Prasad Vallabh,Chaitanya, AU - Hancock,Bruno C, AU - Cetinkaya,Cetin, Y1 - 2013/06/29/ PY - 2013/03/21/received PY - 2013/06/10/revised PY - 2013/06/23/accepted PY - 2013/7/4/entrez PY - 2013/7/4/pubmed PY - 2014/2/28/medline KW - Grain size distribution KW - Granular pharmaceutical solid dosage KW - Mechanical properties KW - Non-destructive characterization techniques KW - Rayleigh scattering KW - Viscoelasticity SP - 333 EP - 43 JF - International journal of pharmaceutics JO - Int J Pharm VL - 454 IS - 1 N2 - The mechanical properties of a solid dosage, defined by its granular micro-structure and geometry, play a key role in its dissolution profile and performance. An ultrasonic method for extracting the viscoelastic material properties and granular structure of drug tablet compacts is introduced and its utility is demonstrated for tablet compacts made of microcrystalline cellulose (MCC), lactose monohydrate, and sodium starch glycolate as well as magnesium stearate as lubricant. The approach is based on the effect of viscoelasticity and internal micro-structures on the frequency-dependent attenuation of an ultrasonic wave propagating in a granular medium. The models for viscoelastic (a two-parameter Zener model) and scattering attenuation (Rayleigh model) mechanisms are employed. The material parameters including viscoelastic and scattering parameters (average Young's modulus, stress and strain relaxation time constants, and the Rayleigh scattering material parameter) and grain size distribution with a known distribution profile are extracted by an optimization algorithm based on the least square method. The results also indicate good agreement between experimentally and computationally determined phase and group velocities in compacted samples. It is found that the effects of both attenuation mechanisms are present and the extracted grain size distribution parameters are in good agreement with the optically determined values. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/23820132/Ultrasonic_approach_for_viscoelastic_and_microstructure_characterization_of_granular_pharmaceutical_tablets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(13)00554-1 DB - PRIME DP - Unbound Medicine ER -