Tags

Type your tag names separated by a space and hit enter

Reviewing the molecular mechanisms which increase endometrial cancer (EC) risk in women with polycystic ovarian syndrome (PCOS): time for paradigm shift?

Abstract

Endometrial cancer (EC) is the commonest gynaecological cancer in North American and European women. Even though it has been shown that women with polycystic ovary syndrome (PCOS) have a three-fold increase in the risk of developing EC compared to women without PCOS, the precise molecular mechanisms which increase EC risk in women with PCOS remain unclear. Clinical strategies to prevent EC in PCOS are therefore not well researched and understood. Although raised estrogen levels, hyperinsulinaemia and, reduced apoptosis have been suggested as potential mechanisms, there is a lack of clarity about how these factors and other factors may interact to increase EC risk in PCOS. This article reviews the literature, on the potential molecular links between PCOS and EC but argues for a paradigm shift, to a systems biology-based approach in future research into the molecular links between PCOS and EC. The potential challenges of a systems biology-based approach are outlined but not considered insurmountable.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    The Division of Obstetrics and Gynaecology and Human Development, School of Clinical Sciences, D Floor, East Block, Queen's Medical Centre, Nottingham University Hospital NHS Trust, Derby Road, NG7 2UH, UK; The Department of Obstetrics and Gynaecology, Faculty of Medicine, UKM Medical Centre, Kuala Lumpur, 56000 Malaysia. Electronic address: mgxmnsh@nottingham.ac.uk.

    , , ,

    Source

    Gynecologic oncology 131:2 2013 Nov pg 489-92

    MeSH

    Endometrial Neoplasms
    Female
    Genomics
    Humans
    Metabolomics
    Polycystic Ovary Syndrome

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    23822891

    Citation

    Shafiee, Mohamad N., et al. "Reviewing the Molecular Mechanisms Which Increase Endometrial Cancer (EC) Risk in Women With Polycystic Ovarian Syndrome (PCOS): Time for Paradigm Shift?" Gynecologic Oncology, vol. 131, no. 2, 2013, pp. 489-92.
    Shafiee MN, Chapman C, Barrett D, et al. Reviewing the molecular mechanisms which increase endometrial cancer (EC) risk in women with polycystic ovarian syndrome (PCOS): time for paradigm shift? Gynecol Oncol. 2013;131(2):489-92.
    Shafiee, M. N., Chapman, C., Barrett, D., Abu, J., & Atiomo, W. (2013). Reviewing the molecular mechanisms which increase endometrial cancer (EC) risk in women with polycystic ovarian syndrome (PCOS): time for paradigm shift? Gynecologic Oncology, 131(2), pp. 489-92. doi:10.1016/j.ygyno.2013.06.032.
    Shafiee MN, et al. Reviewing the Molecular Mechanisms Which Increase Endometrial Cancer (EC) Risk in Women With Polycystic Ovarian Syndrome (PCOS): Time for Paradigm Shift. Gynecol Oncol. 2013;131(2):489-92. PubMed PMID: 23822891.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Reviewing the molecular mechanisms which increase endometrial cancer (EC) risk in women with polycystic ovarian syndrome (PCOS): time for paradigm shift? AU - Shafiee,Mohamad N, AU - Chapman,Caroline, AU - Barrett,David, AU - Abu,Jafaru, AU - Atiomo,William, Y1 - 2013/06/30/ PY - 2013/04/12/received PY - 2013/06/20/revised PY - 2013/06/24/accepted PY - 2013/7/5/entrez PY - 2013/7/5/pubmed PY - 2014/1/7/medline KW - Endometrial cancer KW - Genomic KW - IGF KW - Metabolomics KW - PCOS SP - 489 EP - 92 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 131 IS - 2 N2 - Endometrial cancer (EC) is the commonest gynaecological cancer in North American and European women. Even though it has been shown that women with polycystic ovary syndrome (PCOS) have a three-fold increase in the risk of developing EC compared to women without PCOS, the precise molecular mechanisms which increase EC risk in women with PCOS remain unclear. Clinical strategies to prevent EC in PCOS are therefore not well researched and understood. Although raised estrogen levels, hyperinsulinaemia and, reduced apoptosis have been suggested as potential mechanisms, there is a lack of clarity about how these factors and other factors may interact to increase EC risk in PCOS. This article reviews the literature, on the potential molecular links between PCOS and EC but argues for a paradigm shift, to a systems biology-based approach in future research into the molecular links between PCOS and EC. The potential challenges of a systems biology-based approach are outlined but not considered insurmountable. SN - 1095-6859 UR - https://www.unboundmedicine.com/medline/citation/23822891/Reviewing_the_molecular_mechanisms_which_increase_endometrial_cancer__EC__risk_in_women_with_polycystic_ovarian_syndrome__PCOS_:_time_for_paradigm_shift L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(13)00865-2 DB - PRIME DP - Unbound Medicine ER -