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Serum sclerostin levels associated with lumbar spine bone mineral density and bone turnover markers in patients with postmenopausal osteoporosis.
Chin Med J (Engl). 2013 Jul; 126(13):2480-4.CM

Abstract

BACKGROUND

Sclerostin, expressed exclusively by osteocytes, is a negative regulator of bone formation. To gain insights into the action of sclerostin in postmenopausal osteoporosis, we evaluated serum sclerostin levels in postmenopausal women and investigated its possible associations with bone turnover markers in patients with postmenopausal osteoporosis.

METHODS

We detected serum sclerostin, and measured lumbar spine bone mineral density in 650 Chinese postmenopausal women. We also assessed serum levels of β-isomerized C-terminal crosslinking of type I collagen, intact N-terminal propeptide of type I collagen, N-mid fragment of osteocalcin, 25-hydroxyvitamin D, and estradiol.

RESULTS

Serum sclerostin levels were lower in postmenopausal osteoporotic women compared with non-osteoporotic postmenopausal women ((38.79 ± 7.43) vs. (52.86 ± 6.69) pmol/L, P < 0.001). Serum sclerostin was positively correlated with lumbar spine bone mineral density (r = 0.391, P < 0.001) and weakly negatively correlated with β-isomerized C-terminal crosslinking of type I collagen, intact N-terminal propeptide of type I collagen, N-mid fragment of osteocalcin (r = -0.225, P < 0.001; r = -0.091, P = 0.046; r = -0.108, P = 0.018; respectively) in postmenopausal osteoporosis. There was no significant association of serum sclerostin with age, body mass index, 25-hydroxyvitamin D, and estradiol (r = -0.004, P = 0.926; r = 0.067, P = 0.143; r = 0.063, P = 0.165; r = -0.045, P = 0.324; respectively).

CONCLUSION

Sclerostin may be involved in the pathogenesis of postmenopausal osteoporosis and may play a role in bone turnover.

Authors+Show Affiliations

Department of Integrated Traditional Chinese Medicine and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23823821

Citation

Xu, Xiao-juan, et al. "Serum Sclerostin Levels Associated With Lumbar Spine Bone Mineral Density and Bone Turnover Markers in Patients With Postmenopausal Osteoporosis." Chinese Medical Journal, vol. 126, no. 13, 2013, pp. 2480-4.
Xu XJ, Shen L, Yang YP, et al. Serum sclerostin levels associated with lumbar spine bone mineral density and bone turnover markers in patients with postmenopausal osteoporosis. Chin Med J. 2013;126(13):2480-4.
Xu, X. J., Shen, L., Yang, Y. P., Lu, F. R., Zhu, R., Shuai, B., Li, C. G., & Wu, M. X. (2013). Serum sclerostin levels associated with lumbar spine bone mineral density and bone turnover markers in patients with postmenopausal osteoporosis. Chinese Medical Journal, 126(13), 2480-4.
Xu XJ, et al. Serum Sclerostin Levels Associated With Lumbar Spine Bone Mineral Density and Bone Turnover Markers in Patients With Postmenopausal Osteoporosis. Chin Med J. 2013;126(13):2480-4. PubMed PMID: 23823821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum sclerostin levels associated with lumbar spine bone mineral density and bone turnover markers in patients with postmenopausal osteoporosis. AU - Xu,Xiao-juan, AU - Shen,Lin, AU - Yang,Yan-ping, AU - Lu,Fu-rong, AU - Zhu,Rui, AU - Shuai,Bo, AU - Li,Cheng-gang, AU - Wu,Man-xiang, PY - 2013/7/5/entrez PY - 2013/7/5/pubmed PY - 2014/1/24/medline SP - 2480 EP - 4 JF - Chinese medical journal JO - Chin. Med. J. VL - 126 IS - 13 N2 - BACKGROUND: Sclerostin, expressed exclusively by osteocytes, is a negative regulator of bone formation. To gain insights into the action of sclerostin in postmenopausal osteoporosis, we evaluated serum sclerostin levels in postmenopausal women and investigated its possible associations with bone turnover markers in patients with postmenopausal osteoporosis. METHODS: We detected serum sclerostin, and measured lumbar spine bone mineral density in 650 Chinese postmenopausal women. We also assessed serum levels of β-isomerized C-terminal crosslinking of type I collagen, intact N-terminal propeptide of type I collagen, N-mid fragment of osteocalcin, 25-hydroxyvitamin D, and estradiol. RESULTS: Serum sclerostin levels were lower in postmenopausal osteoporotic women compared with non-osteoporotic postmenopausal women ((38.79 ± 7.43) vs. (52.86 ± 6.69) pmol/L, P < 0.001). Serum sclerostin was positively correlated with lumbar spine bone mineral density (r = 0.391, P < 0.001) and weakly negatively correlated with β-isomerized C-terminal crosslinking of type I collagen, intact N-terminal propeptide of type I collagen, N-mid fragment of osteocalcin (r = -0.225, P < 0.001; r = -0.091, P = 0.046; r = -0.108, P = 0.018; respectively) in postmenopausal osteoporosis. There was no significant association of serum sclerostin with age, body mass index, 25-hydroxyvitamin D, and estradiol (r = -0.004, P = 0.926; r = 0.067, P = 0.143; r = 0.063, P = 0.165; r = -0.045, P = 0.324; respectively). CONCLUSION: Sclerostin may be involved in the pathogenesis of postmenopausal osteoporosis and may play a role in bone turnover. SN - 2542-5641 UR - https://www.unboundmedicine.com/medline/citation/23823821/Serum_sclerostin_levels_associated_with_lumbar_spine_bone_mineral_density_and_bone_turnover_markers_in_patients_with_postmenopausal_osteoporosis_ L2 - http://Insights.ovid.com/pubmed?pmid=23823821 DB - PRIME DP - Unbound Medicine ER -