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Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain (1990-2009).
Int J Cancer 2014; 134(2):487-92IJ

Abstract

Recent studies support an important role for human papillomavirus (HPV) in oropharyngeal squamous cell carcinomas (OPSCC), although the incidence varies widely depending on the geographic location and time period studied. The aim of this study was to determine the proportion of HPV in a large cohort of OPSCC in northern Spain in the years 1990-2009. Clinical records and paraffin embedded tumor specimens of 248 consecutive patients surgically treated for OPSCC (140 tonsillar and 108 base of tongue) between 1990 and 2009 were retrieved. OPSCC cases were histomorphologically evaluated, and protein expression of p16 and p53 was analyzed by immunohistochemistry. Detection of high-risk HPV DNA was performed by GP5+/6+-PCR and in situ hybridization (ISH). Thirty cases (12%) were positive for p16 immunostaining, of which eight (3.2% of the total series) were found positive for HPV type 16 by genotyping of GP5+6+-PCR products. All HPV GP5+/6+-PCR-positive tumors were p53-immunonegative, seven had a basaloid morphology and seven were also positive by HPV ISH. Presence of HPV correlated inversely with tobacco and alcohol consumption (p < 0.001), but not with age of onset of OPSCC. Overall survival was better in the HPV-positive group, although not statistically significant (p = 0.175). OPSCC patients in northern Spain demonstrated a low involvement of HPV, increasing (although not significantly, p = 0.120) from 1.8% in 1990-1999 to 6.1% of cases in 2000-2009.

Authors+Show Affiliations

Department of Otolaryngology, IUOPA, Hospital Universitario Central de Asturias, Oviedo, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23824638

Citation

Rodrigo, Juan P., et al. "Time Trends in the Prevalence of HPV in Oropharyngeal Squamous Cell Carcinomas in Northern Spain (1990-2009)." International Journal of Cancer, vol. 134, no. 2, 2014, pp. 487-92.
Rodrigo JP, Heideman DA, García-Pedrero JM, et al. Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain (1990-2009). Int J Cancer. 2014;134(2):487-92.
Rodrigo, J. P., Heideman, D. A., García-Pedrero, J. M., Fresno, M. F., Brakenhoff, R. H., Díaz Molina, J. P., ... Hermsen, M. A. (2014). Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain (1990-2009). International Journal of Cancer, 134(2), pp. 487-92. doi:10.1002/ijc.28355.
Rodrigo JP, et al. Time Trends in the Prevalence of HPV in Oropharyngeal Squamous Cell Carcinomas in Northern Spain (1990-2009). Int J Cancer. 2014 Jan 15;134(2):487-92. PubMed PMID: 23824638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain (1990-2009). AU - Rodrigo,Juan P, AU - Heideman,Daniëlle A M, AU - García-Pedrero,Juana M, AU - Fresno,Manuel F, AU - Brakenhoff,Ruud H, AU - Díaz Molina,Juan P, AU - Snijders,Peter J F, AU - Hermsen,Mario A, Y1 - 2013/07/27/ PY - 2013/03/11/received PY - 2013/05/06/revised PY - 2013/06/14/accepted PY - 2013/7/5/entrez PY - 2013/7/5/pubmed PY - 2014/4/16/medline KW - PCR KW - human papillomavirus KW - immunohistochemistry KW - in situ hybridization KW - oropharyngeal squamous cell carcinoma SP - 487 EP - 92 JF - International journal of cancer JO - Int. J. Cancer VL - 134 IS - 2 N2 - Recent studies support an important role for human papillomavirus (HPV) in oropharyngeal squamous cell carcinomas (OPSCC), although the incidence varies widely depending on the geographic location and time period studied. The aim of this study was to determine the proportion of HPV in a large cohort of OPSCC in northern Spain in the years 1990-2009. Clinical records and paraffin embedded tumor specimens of 248 consecutive patients surgically treated for OPSCC (140 tonsillar and 108 base of tongue) between 1990 and 2009 were retrieved. OPSCC cases were histomorphologically evaluated, and protein expression of p16 and p53 was analyzed by immunohistochemistry. Detection of high-risk HPV DNA was performed by GP5+/6+-PCR and in situ hybridization (ISH). Thirty cases (12%) were positive for p16 immunostaining, of which eight (3.2% of the total series) were found positive for HPV type 16 by genotyping of GP5+6+-PCR products. All HPV GP5+/6+-PCR-positive tumors were p53-immunonegative, seven had a basaloid morphology and seven were also positive by HPV ISH. Presence of HPV correlated inversely with tobacco and alcohol consumption (p < 0.001), but not with age of onset of OPSCC. Overall survival was better in the HPV-positive group, although not statistically significant (p = 0.175). OPSCC patients in northern Spain demonstrated a low involvement of HPV, increasing (although not significantly, p = 0.120) from 1.8% in 1990-1999 to 6.1% of cases in 2000-2009. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/23824638/Time_trends_in_the_prevalence_of_HPV_in_oropharyngeal_squamous_cell_carcinomas_in_northern_Spain__1990_2009__ L2 - https://doi.org/10.1002/ijc.28355 DB - PRIME DP - Unbound Medicine ER -