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Association between apolipoprotein E gene polymorphism and the risk of coronary artery disease in Chinese population: evidence from a meta-analysis of 40 studies.
PLoS One. 2013; 8(6):e66924.Plos

Abstract

BACKGROUND

Epidemiological studies have evaluated the association between apolipoprotein E (ApoE) gene polymorphism and coronary artery disease (CAD) risk which developed inconsistent conclusions. To derive a more precise estimation of the relationship in Chinese population, we performed this meta-analysis.

METHODS

Databases, including PubMed, EMbase, Web of Science, CBMdisc and CNKI, were searched to get the genetic association studies. Additionally, hand searching of the references of identified articles were performed. All the statistical tests were performed using Review Manager 5.1.2 and Stata 11.0.

RESULTS

We identified a total of 40 studies, including 4,564 CAD cases and 3,985 controls. The results showed evidence for significant association between ApoE ε4 allele and CAD risk (for ε2/ε4 vs. ε3/ε3: OR = 1.86, 95% CI = 1.42-2.43, p<0.00001; for ε3/ε4 vs. ε3/ε3: OR = 2.34, 95% CI = 2.07-2.65, p<0.00001; for ε4/ε4 vs. ε3/ε3: OR = 2.89, 95% CI = 1.87-4.47, p<0.00001; for ε4 allele vs. ε3 allele: OR = 2.11, 95% CI = 1.91-2.35, p<0.00001).

CONCLUSIONS

The present meta-analysis suggests an association between ApoE ε4 allele and increased risk of CAD in Chinese population. However, due to the small sample size in most of the included studies and the selection bias existed in some studies, the results should be interpreted with caution.

Authors+Show Affiliations

Department of Emergency, Chinese PLA Air Force General Hospital, Beijing, PR China. shuaishuaijita@sohu.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

23826174

Citation

Yin, Yan-Wei, et al. "Association Between Apolipoprotein E Gene Polymorphism and the Risk of Coronary Artery Disease in Chinese Population: Evidence From a Meta-analysis of 40 Studies." PloS One, vol. 8, no. 6, 2013, pp. e66924.
Yin YW, Sun QQ, Zhang BB, et al. Association between apolipoprotein E gene polymorphism and the risk of coronary artery disease in Chinese population: evidence from a meta-analysis of 40 studies. PLoS One. 2013;8(6):e66924.
Yin, Y. W., Sun, Q. Q., Zhang, B. B., Hu, A. M., Liu, H. L., Wang, Q., & Hou, Z. Z. (2013). Association between apolipoprotein E gene polymorphism and the risk of coronary artery disease in Chinese population: evidence from a meta-analysis of 40 studies. PloS One, 8(6), e66924. https://doi.org/10.1371/journal.pone.0066924
Yin YW, et al. Association Between Apolipoprotein E Gene Polymorphism and the Risk of Coronary Artery Disease in Chinese Population: Evidence From a Meta-analysis of 40 Studies. PLoS One. 2013;8(6):e66924. PubMed PMID: 23826174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between apolipoprotein E gene polymorphism and the risk of coronary artery disease in Chinese population: evidence from a meta-analysis of 40 studies. AU - Yin,Yan-Wei, AU - Sun,Qian-Qian, AU - Zhang,Bei-Bei, AU - Hu,Ai-Min, AU - Liu,Hong-Li, AU - Wang,Qi, AU - Hou,Zhi-Zhen, Y1 - 2013/06/24/ PY - 2012/12/18/received PY - 2013/05/13/accepted PY - 2013/7/5/entrez PY - 2013/7/5/pubmed PY - 2014/2/5/medline SP - e66924 EP - e66924 JF - PloS one JO - PLoS One VL - 8 IS - 6 N2 - BACKGROUND: Epidemiological studies have evaluated the association between apolipoprotein E (ApoE) gene polymorphism and coronary artery disease (CAD) risk which developed inconsistent conclusions. To derive a more precise estimation of the relationship in Chinese population, we performed this meta-analysis. METHODS: Databases, including PubMed, EMbase, Web of Science, CBMdisc and CNKI, were searched to get the genetic association studies. Additionally, hand searching of the references of identified articles were performed. All the statistical tests were performed using Review Manager 5.1.2 and Stata 11.0. RESULTS: We identified a total of 40 studies, including 4,564 CAD cases and 3,985 controls. The results showed evidence for significant association between ApoE ε4 allele and CAD risk (for ε2/ε4 vs. ε3/ε3: OR = 1.86, 95% CI = 1.42-2.43, p<0.00001; for ε3/ε4 vs. ε3/ε3: OR = 2.34, 95% CI = 2.07-2.65, p<0.00001; for ε4/ε4 vs. ε3/ε3: OR = 2.89, 95% CI = 1.87-4.47, p<0.00001; for ε4 allele vs. ε3 allele: OR = 2.11, 95% CI = 1.91-2.35, p<0.00001). CONCLUSIONS: The present meta-analysis suggests an association between ApoE ε4 allele and increased risk of CAD in Chinese population. However, due to the small sample size in most of the included studies and the selection bias existed in some studies, the results should be interpreted with caution. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23826174/Association_between_apolipoprotein_E_gene_polymorphism_and_the_risk_of_coronary_artery_disease_in_Chinese_population:_evidence_from_a_meta_analysis_of_40_studies_ L2 - https://dx.plos.org/10.1371/journal.pone.0066924 DB - PRIME DP - Unbound Medicine ER -