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Abscisic Acid Promotes Susceptibility to the Rice Leaf Blight Pathogen Xanthomonas oryzae pv oryzae by Suppressing Salicylic Acid-Mediated Defenses.
PLoS One 2013; 8(6):e67413Plos

Abstract

The plant hormone abscisic acid (ABA) is involved in a wide variety of plant processes, including the initiation of stress-adaptive responses to various environmental cues. Recently, ABA also emerged as a central factor in the regulation and integration of plant immune responses, although little is known about the underlying mechanisms. Aiming to advance our understanding of ABA-modulated disease resistance, we have analyzed the impact, dynamics and interrelationship of ABA and the classic defense hormone salicylic acid (SA) during progression of rice infection by the leaf blight pathogen Xanthomonas oryzae pv. oryzae (Xoo). Consistent with ABA negatively regulating resistance to Xoo, we found that exogenously administered ABA renders rice hypersusceptible to infection, whereas chemical and genetic disruption of ABA biosynthesis and signaling, respectively, led to enhanced Xoo resistance. In addition, we found successful Xoo infection to be associated with extensive reprogramming of ABA biosynthesis and response genes, suggesting that ABA functions as a virulence factor for Xoo. Interestingly, several lines of evidence indicate that this immune-suppressive effect of ABA is due at least in part to suppression of SA-mediated defenses that normally serve to limit pathogen growth. Resistance induced by the ABA biosynthesis inhibitor fluridone, however, appears to operate in a SA-independent manner and is likely due to induction of non-specific physiological stress. Collectively, our findings favor a scenario whereby virulent Xoo hijacks the rice ABA machinery to cause disease and highlight the importance of ABA and its crosstalk with SA in shaping the outcome of rice-Xoo interactions.

Authors+Show Affiliations

Laboratory of Phytopathology, Ghent University, Ghent, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23826294

Citation

Xu, Jing, et al. "Abscisic Acid Promotes Susceptibility to the Rice Leaf Blight Pathogen Xanthomonas Oryzae Pv Oryzae By Suppressing Salicylic Acid-Mediated Defenses." PloS One, vol. 8, no. 6, 2013, pp. e67413.
Xu J, Audenaert K, Hofte M, et al. Abscisic Acid Promotes Susceptibility to the Rice Leaf Blight Pathogen Xanthomonas oryzae pv oryzae by Suppressing Salicylic Acid-Mediated Defenses. PLoS ONE. 2013;8(6):e67413.
Xu, J., Audenaert, K., Hofte, M., & De Vleesschauwer, D. (2013). Abscisic Acid Promotes Susceptibility to the Rice Leaf Blight Pathogen Xanthomonas oryzae pv oryzae by Suppressing Salicylic Acid-Mediated Defenses. PloS One, 8(6), pp. e67413. doi:10.1371/journal.pone.0067413.
Xu J, et al. Abscisic Acid Promotes Susceptibility to the Rice Leaf Blight Pathogen Xanthomonas Oryzae Pv Oryzae By Suppressing Salicylic Acid-Mediated Defenses. PLoS ONE. 2013;8(6):e67413. PubMed PMID: 23826294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abscisic Acid Promotes Susceptibility to the Rice Leaf Blight Pathogen Xanthomonas oryzae pv oryzae by Suppressing Salicylic Acid-Mediated Defenses. AU - Xu,Jing, AU - Audenaert,Kris, AU - Hofte,Monica, AU - De Vleesschauwer,David, Y1 - 2013/06/27/ PY - 2013/02/24/received PY - 2013/05/17/accepted PY - 2013/7/5/entrez PY - 2013/7/5/pubmed PY - 2013/7/5/medline SP - e67413 EP - e67413 JF - PloS one JO - PLoS ONE VL - 8 IS - 6 N2 - The plant hormone abscisic acid (ABA) is involved in a wide variety of plant processes, including the initiation of stress-adaptive responses to various environmental cues. Recently, ABA also emerged as a central factor in the regulation and integration of plant immune responses, although little is known about the underlying mechanisms. Aiming to advance our understanding of ABA-modulated disease resistance, we have analyzed the impact, dynamics and interrelationship of ABA and the classic defense hormone salicylic acid (SA) during progression of rice infection by the leaf blight pathogen Xanthomonas oryzae pv. oryzae (Xoo). Consistent with ABA negatively regulating resistance to Xoo, we found that exogenously administered ABA renders rice hypersusceptible to infection, whereas chemical and genetic disruption of ABA biosynthesis and signaling, respectively, led to enhanced Xoo resistance. In addition, we found successful Xoo infection to be associated with extensive reprogramming of ABA biosynthesis and response genes, suggesting that ABA functions as a virulence factor for Xoo. Interestingly, several lines of evidence indicate that this immune-suppressive effect of ABA is due at least in part to suppression of SA-mediated defenses that normally serve to limit pathogen growth. Resistance induced by the ABA biosynthesis inhibitor fluridone, however, appears to operate in a SA-independent manner and is likely due to induction of non-specific physiological stress. Collectively, our findings favor a scenario whereby virulent Xoo hijacks the rice ABA machinery to cause disease and highlight the importance of ABA and its crosstalk with SA in shaping the outcome of rice-Xoo interactions. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23826294/Abscisic_Acid_Promotes_Susceptibility_to_the_Rice_Leaf_Blight_Pathogen_Xanthomonas_oryzae_pv_oryzae_by_Suppressing_Salicylic_Acid_Mediated_Defenses_ L2 - http://dx.plos.org/10.1371/journal.pone.0067413 DB - PRIME DP - Unbound Medicine ER -