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Cronkhite-Canada syndrome complicated with multiple gastric cancers and multiple colon adenomas.
Am J Case Rep. 2013; 14:120-8.AJ

Abstract

BACKGROUND

We experienced a case in which Cronkhite-Canada Syndrome presented with complications of multiple gastric cancers and multiple colon adenomas.

CASE REPORT

Our case is a 64-year-old male who visited a nearby hospital with diarrhea and weight loss. The patient was anemic and hypoproteinemic, with multiple polyps in the stomach, duodenum, and large intestine. He also presented with alopecia, onychatrophia, cutaneous pigmentation, and dysgeusia, and was diagnosed with Cronkhite-Canada Syndrome. Follow-up examinations found multiple gastric cancers and colon adenomas. We performed a total gastrectomy and a polypectomy of the large intestine lesions, revealing 4 well-differentiated adenocarcinomas in the resected stomach, and tubular adenomas in the large intestine lesions. Intraoperative findings included scattered melanoid pigmentation on the mesentery and the small intestinal wall. Tumor cells were positive for p53 and Ki67 and partially positive for MUC5AC and MUC2. Cronkhite-Canada Syndrome polyps are generally classified as juvenile type polyps, and these polyps rarely become cancerous. However, of the 383 cases of Cronkhite-Canada Syndrome reported in Japan, complications of gastric cancer were found in 39 cases (10.2%), and only 8 cases with multiple gastric cancer were reported in Japan. including the cases we have personally experienced. There were only two English literatures on Cronkhite-Canada Syndrome complicated with gastric cancer. So it is necessary to notify this information of Cronkhite-Canada Syndrome to the world.

CONCLUSIONS

Close gastrointestinal examination and strict follow-up are believed to be essential for Cronkhite-Canada Syndrome patients.

Authors+Show Affiliations

Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23826450

Citation

Isobe, Taro, et al. "Cronkhite-Canada Syndrome Complicated With Multiple Gastric Cancers and Multiple Colon Adenomas." The American Journal of Case Reports, vol. 14, 2013, pp. 120-8.
Isobe T, Kobayashi T, Hashimoto K, et al. Cronkhite-Canada syndrome complicated with multiple gastric cancers and multiple colon adenomas. Am J Case Rep. 2013;14:120-8.
Isobe, T., Kobayashi, T., Hashimoto, K., Kizaki, J., Miyagi, M., Aoyagi, K., Koufuji, K., & Shirouzu, K. (2013). Cronkhite-Canada syndrome complicated with multiple gastric cancers and multiple colon adenomas. The American Journal of Case Reports, 14, 120-8. https://doi.org/10.12659/AJCR.889083
Isobe T, et al. Cronkhite-Canada Syndrome Complicated With Multiple Gastric Cancers and Multiple Colon Adenomas. Am J Case Rep. 2013;14:120-8. PubMed PMID: 23826450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cronkhite-Canada syndrome complicated with multiple gastric cancers and multiple colon adenomas. AU - Isobe,Taro, AU - Kobayashi,Teppei, AU - Hashimoto,Kousuke, AU - Kizaki,Junya, AU - Miyagi,Motoshi, AU - Aoyagi,Keishiro, AU - Koufuji,Kikuo, AU - Shirouzu,Kazuo, Y1 - 2013/04/26/ PY - 2013/02/21/received PY - 2013/04/03/accepted PY - 2013/7/5/entrez PY - 2013/7/5/pubmed PY - 2013/7/5/medline KW - Cronkhite-Canada syndrome KW - colon adenoma KW - gastric cancer SP - 120 EP - 8 JF - The American journal of case reports JO - Am J Case Rep VL - 14 N2 - BACKGROUND: We experienced a case in which Cronkhite-Canada Syndrome presented with complications of multiple gastric cancers and multiple colon adenomas. CASE REPORT: Our case is a 64-year-old male who visited a nearby hospital with diarrhea and weight loss. The patient was anemic and hypoproteinemic, with multiple polyps in the stomach, duodenum, and large intestine. He also presented with alopecia, onychatrophia, cutaneous pigmentation, and dysgeusia, and was diagnosed with Cronkhite-Canada Syndrome. Follow-up examinations found multiple gastric cancers and colon adenomas. We performed a total gastrectomy and a polypectomy of the large intestine lesions, revealing 4 well-differentiated adenocarcinomas in the resected stomach, and tubular adenomas in the large intestine lesions. Intraoperative findings included scattered melanoid pigmentation on the mesentery and the small intestinal wall. Tumor cells were positive for p53 and Ki67 and partially positive for MUC5AC and MUC2. Cronkhite-Canada Syndrome polyps are generally classified as juvenile type polyps, and these polyps rarely become cancerous. However, of the 383 cases of Cronkhite-Canada Syndrome reported in Japan, complications of gastric cancer were found in 39 cases (10.2%), and only 8 cases with multiple gastric cancer were reported in Japan. including the cases we have personally experienced. There were only two English literatures on Cronkhite-Canada Syndrome complicated with gastric cancer. So it is necessary to notify this information of Cronkhite-Canada Syndrome to the world. CONCLUSIONS: Close gastrointestinal examination and strict follow-up are believed to be essential for Cronkhite-Canada Syndrome patients. SN - 1941-5923 UR - https://www.unboundmedicine.com/medline/citation/23826450/Cronkhite_Canada_syndrome_complicated_with_multiple_gastric_cancers_and_multiple_colon_adenomas_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23826450/ DB - PRIME DP - Unbound Medicine ER -
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