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Interaction of antihypertensive acetazolamide with nonsteroidal anti-inflammatory drugs.
J Photochem Photobiol B. 2013 Aug 05; 125:155-63.JP

Abstract

The binding of antihypertensive acetazolamide with eleven nonsteroidal anti-inflammatory drugs (NSAIDs) was investigated at pH 3, 7 and 9.5 with the objective of monitoring their interactive pharmacokinetics during digestion and absorption in human body. The results of UV-Vis spectroscopy and cyclic voltammetry revealed two NSAIDs (acetaminophen and dichlofenic sodium) to interact with acetazolamide in stomach fluid conditions forming complexes of 1:1 and 1:2 stoichiometry. The complexation ratio was also verified by computational methods. The strong binding propensity of acetaminophen and dichlofenic sodium with acetazolamide prohibited their combined therapy. However, the poor binding affinity of aspirin and mefinamic acid suggested these drugs as preferred NSAIDs to be prescribed with acetazolamide.

Authors+Show Affiliations

Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23827754

Citation

Jabeen, Erum, et al. "Interaction of Antihypertensive Acetazolamide With Nonsteroidal Anti-inflammatory Drugs." Journal of Photochemistry and Photobiology. B, Biology, vol. 125, 2013, pp. 155-63.
Jabeen E, Qureshi R, Shah A. Interaction of antihypertensive acetazolamide with nonsteroidal anti-inflammatory drugs. J Photochem Photobiol B, Biol. 2013;125:155-63.
Jabeen, E., Qureshi, R., & Shah, A. (2013). Interaction of antihypertensive acetazolamide with nonsteroidal anti-inflammatory drugs. Journal of Photochemistry and Photobiology. B, Biology, 125, 155-63. https://doi.org/10.1016/j.jphotobiol.2013.06.002
Jabeen E, Qureshi R, Shah A. Interaction of Antihypertensive Acetazolamide With Nonsteroidal Anti-inflammatory Drugs. J Photochem Photobiol B, Biol. 2013 Aug 5;125:155-63. PubMed PMID: 23827754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of antihypertensive acetazolamide with nonsteroidal anti-inflammatory drugs. AU - Jabeen,Erum, AU - Qureshi,Rumana, AU - Shah,Afzal, Y1 - 2013/06/14/ PY - 2013/04/23/received PY - 2013/05/30/revised PY - 2013/06/06/accepted PY - 2013/7/6/entrez PY - 2013/7/6/pubmed PY - 2014/2/19/medline KW - Hyperchromism KW - Hypsochromic effect KW - Interaction KW - Isosbestic point KW - Stoichiometry SP - 155 EP - 63 JF - Journal of photochemistry and photobiology. B, Biology JO - J. Photochem. Photobiol. B, Biol. VL - 125 N2 - The binding of antihypertensive acetazolamide with eleven nonsteroidal anti-inflammatory drugs (NSAIDs) was investigated at pH 3, 7 and 9.5 with the objective of monitoring their interactive pharmacokinetics during digestion and absorption in human body. The results of UV-Vis spectroscopy and cyclic voltammetry revealed two NSAIDs (acetaminophen and dichlofenic sodium) to interact with acetazolamide in stomach fluid conditions forming complexes of 1:1 and 1:2 stoichiometry. The complexation ratio was also verified by computational methods. The strong binding propensity of acetaminophen and dichlofenic sodium with acetazolamide prohibited their combined therapy. However, the poor binding affinity of aspirin and mefinamic acid suggested these drugs as preferred NSAIDs to be prescribed with acetazolamide. SN - 1873-2682 UR - https://www.unboundmedicine.com/medline/citation/23827754/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1011-1344(13)00123-1 DB - PRIME DP - Unbound Medicine ER -