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Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease.
Gut 2014; 63(5):776-84Gut

Abstract

INTRODUCTION

Dietary fats influence intestinal inflammation and regulate mucosal immunity. Data on the association between dietary fat and risk of Crohn's disease (CD) and ulcerative colitis (UC) are limited and conflicting.

METHODS

We conducted a prospective study of women enrolled in the Nurses' Health Study cohorts. Diet was prospectively ascertained every 4 years using a validated semi-quantitative food frequency questionnaire. Self-reported CD and UC were confirmed through medical record review. We examined the effect of energy-adjusted cumulative average total fat intake and specific types of fat and fatty acids on the risk of CD and UC using Cox proportional hazards models adjusting for potential confounders.

RESULTS

Among 170,805 women, we confirmed 269 incident cases of CD (incidence 8/100,000 person-years) and 338 incident cases of UC (incidence 10/100,000 person-years) over 26 years and 3,317,338 person-years of follow-up. Cumulative energy-adjusted intake of total fat, saturated fats, unsaturated fats, n-6 and n-3 polyunsaturated fatty acids (PUFAs) were not associated with risk of CD or UC. However, greater intake of long-chain n-3 PUFAs was associated with a trend towards lower risk of UC (HR 0.72, 95% CI 0.51 to 1.01). In contrast, high long-term intake of trans-unsaturated fatty acids was associated with a trend towards an increased incidence of UC (HR 1.34, 95% CI 0.94 to 1.92).

CONCLUSIONS

A high intake of dietary long-chain n-3 PUFAs may be associated with a reduced risk of UC. In contrast, high intake of trans-unsaturated fats may be associated with an increased risk of UC.

Authors+Show Affiliations

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, , Boston, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23828881

Citation

Ananthakrishnan, Ashwin N., et al. "Long-term Intake of Dietary Fat and Risk of Ulcerative Colitis and Crohn's Disease." Gut, vol. 63, no. 5, 2014, pp. 776-84.
Ananthakrishnan AN, Khalili H, Konijeti GG, et al. Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease. Gut. 2014;63(5):776-84.
Ananthakrishnan, A. N., Khalili, H., Konijeti, G. G., Higuchi, L. M., de Silva, P., Fuchs, C. S., ... Chan, A. T. (2014). Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease. Gut, 63(5), pp. 776-84. doi:10.1136/gutjnl-2013-305304.
Ananthakrishnan AN, et al. Long-term Intake of Dietary Fat and Risk of Ulcerative Colitis and Crohn's Disease. Gut. 2014;63(5):776-84. PubMed PMID: 23828881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease. AU - Ananthakrishnan,Ashwin N, AU - Khalili,Hamed, AU - Konijeti,Gauree G, AU - Higuchi,Leslie M, AU - de Silva,Punyanganie, AU - Fuchs,Charles S, AU - Willett,Walter C, AU - Richter,James M, AU - Chan,Andrew T, Y1 - 2013/07/04/ PY - 2013/7/6/entrez PY - 2013/7/6/pubmed PY - 2014/6/3/medline KW - Crohn's Disease KW - Diet KW - Dietary Factors KW - Ulcerative Colitis SP - 776 EP - 84 JF - Gut JO - Gut VL - 63 IS - 5 N2 - INTRODUCTION: Dietary fats influence intestinal inflammation and regulate mucosal immunity. Data on the association between dietary fat and risk of Crohn's disease (CD) and ulcerative colitis (UC) are limited and conflicting. METHODS: We conducted a prospective study of women enrolled in the Nurses' Health Study cohorts. Diet was prospectively ascertained every 4 years using a validated semi-quantitative food frequency questionnaire. Self-reported CD and UC were confirmed through medical record review. We examined the effect of energy-adjusted cumulative average total fat intake and specific types of fat and fatty acids on the risk of CD and UC using Cox proportional hazards models adjusting for potential confounders. RESULTS: Among 170,805 women, we confirmed 269 incident cases of CD (incidence 8/100,000 person-years) and 338 incident cases of UC (incidence 10/100,000 person-years) over 26 years and 3,317,338 person-years of follow-up. Cumulative energy-adjusted intake of total fat, saturated fats, unsaturated fats, n-6 and n-3 polyunsaturated fatty acids (PUFAs) were not associated with risk of CD or UC. However, greater intake of long-chain n-3 PUFAs was associated with a trend towards lower risk of UC (HR 0.72, 95% CI 0.51 to 1.01). In contrast, high long-term intake of trans-unsaturated fatty acids was associated with a trend towards an increased incidence of UC (HR 1.34, 95% CI 0.94 to 1.92). CONCLUSIONS: A high intake of dietary long-chain n-3 PUFAs may be associated with a reduced risk of UC. In contrast, high intake of trans-unsaturated fats may be associated with an increased risk of UC. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/23828881/Long_term_intake_of_dietary_fat_and_risk_of_ulcerative_colitis_and_Crohn's_disease_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=23828881 DB - PRIME DP - Unbound Medicine ER -