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Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease.

Abstract

INTRODUCTION

Dietary fats influence intestinal inflammation and regulate mucosal immunity. Data on the association between dietary fat and risk of Crohn's disease (CD) and ulcerative colitis (UC) are limited and conflicting.

METHODS

We conducted a prospective study of women enrolled in the Nurses' Health Study cohorts. Diet was prospectively ascertained every 4 years using a validated semi-quantitative food frequency questionnaire. Self-reported CD and UC were confirmed through medical record review. We examined the effect of energy-adjusted cumulative average total fat intake and specific types of fat and fatty acids on the risk of CD and UC using Cox proportional hazards models adjusting for potential confounders.

RESULTS

Among 170,805 women, we confirmed 269 incident cases of CD (incidence 8/100,000 person-years) and 338 incident cases of UC (incidence 10/100,000 person-years) over 26 years and 3,317,338 person-years of follow-up. Cumulative energy-adjusted intake of total fat, saturated fats, unsaturated fats, n-6 and n-3 polyunsaturated fatty acids (PUFAs) were not associated with risk of CD or UC. However, greater intake of long-chain n-3 PUFAs was associated with a trend towards lower risk of UC (HR 0.72, 95% CI 0.51 to 1.01). In contrast, high long-term intake of trans-unsaturated fatty acids was associated with a trend towards an increased incidence of UC (HR 1.34, 95% CI 0.94 to 1.92).

CONCLUSIONS

A high intake of dietary long-chain n-3 PUFAs may be associated with a reduced risk of UC. In contrast, high intake of trans-unsaturated fats may be associated with an increased risk of UC.

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  • Authors+Show Affiliations

    ,

    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, , Boston, Massachusetts, USA.

    , , , , , , ,

    Source

    Gut 63:5 2014 May pg 776-84

    MeSH

    Adult
    Colitis, Ulcerative
    Crohn Disease
    Diet Surveys
    Dietary Fats
    Female
    Follow-Up Studies
    Humans
    Incidence
    Middle Aged
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Self Report
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    23828881

    Citation

    Ananthakrishnan, Ashwin N., et al. "Long-term Intake of Dietary Fat and Risk of Ulcerative Colitis and Crohn's Disease." Gut, vol. 63, no. 5, 2014, pp. 776-84.
    Ananthakrishnan AN, Khalili H, Konijeti GG, et al. Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease. Gut. 2014;63(5):776-84.
    Ananthakrishnan, A. N., Khalili, H., Konijeti, G. G., Higuchi, L. M., de Silva, P., Fuchs, C. S., ... Chan, A. T. (2014). Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease. Gut, 63(5), pp. 776-84. doi:10.1136/gutjnl-2013-305304.
    Ananthakrishnan AN, et al. Long-term Intake of Dietary Fat and Risk of Ulcerative Colitis and Crohn's Disease. Gut. 2014;63(5):776-84. PubMed PMID: 23828881.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease. AU - Ananthakrishnan,Ashwin N, AU - Khalili,Hamed, AU - Konijeti,Gauree G, AU - Higuchi,Leslie M, AU - de Silva,Punyanganie, AU - Fuchs,Charles S, AU - Willett,Walter C, AU - Richter,James M, AU - Chan,Andrew T, Y1 - 2013/07/04/ PY - 2013/7/6/entrez PY - 2013/7/6/pubmed PY - 2014/6/3/medline KW - Crohn's Disease KW - Diet KW - Dietary Factors KW - Ulcerative Colitis SP - 776 EP - 84 JF - Gut JO - Gut VL - 63 IS - 5 N2 - INTRODUCTION: Dietary fats influence intestinal inflammation and regulate mucosal immunity. Data on the association between dietary fat and risk of Crohn's disease (CD) and ulcerative colitis (UC) are limited and conflicting. METHODS: We conducted a prospective study of women enrolled in the Nurses' Health Study cohorts. Diet was prospectively ascertained every 4 years using a validated semi-quantitative food frequency questionnaire. Self-reported CD and UC were confirmed through medical record review. We examined the effect of energy-adjusted cumulative average total fat intake and specific types of fat and fatty acids on the risk of CD and UC using Cox proportional hazards models adjusting for potential confounders. RESULTS: Among 170,805 women, we confirmed 269 incident cases of CD (incidence 8/100,000 person-years) and 338 incident cases of UC (incidence 10/100,000 person-years) over 26 years and 3,317,338 person-years of follow-up. Cumulative energy-adjusted intake of total fat, saturated fats, unsaturated fats, n-6 and n-3 polyunsaturated fatty acids (PUFAs) were not associated with risk of CD or UC. However, greater intake of long-chain n-3 PUFAs was associated with a trend towards lower risk of UC (HR 0.72, 95% CI 0.51 to 1.01). In contrast, high long-term intake of trans-unsaturated fatty acids was associated with a trend towards an increased incidence of UC (HR 1.34, 95% CI 0.94 to 1.92). CONCLUSIONS: A high intake of dietary long-chain n-3 PUFAs may be associated with a reduced risk of UC. In contrast, high intake of trans-unsaturated fats may be associated with an increased risk of UC. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/23828881/Long_term_intake_of_dietary_fat_and_risk_of_ulcerative_colitis_and_Crohn's_disease_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=23828881 DB - PRIME DP - Unbound Medicine ER -