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Biphasic effects of Δ9-tetrahydrocannabinol on brain stimulation reward and motor activity.
Int J Neuropsychopharmacol. 2013 Nov; 16(10):2273-84.IJ

Abstract

Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the main psychoactive ingredient of marijuana, has led to equivocal results when tested with the intracranial self-stimulation (ICSS) procedure or the open-field test for motor activity, two behavioural models for evaluating the reward-facilitating and locomotor stimulating effects of drugs of abuse, respectively. Therefore, in the present study, the effects of high and low doses of Δ(9)-THC were compared in the ICSS procedure and the open-field test. Moreover, the involvement of CB(1) receptors in tentative Δ(9)-THC-induced effects was investigated by pre-treating the animals with the CB(1) receptor antagonist SR141716A (rimonabant). The results obtained show that low doses of Δ(9)-THC induce opposite effects from high doses of Δ(9)-THC. Specifically, 0.1 mg/kg Δ(9)-THC decreased ICSS thresholds and produced hyperactivity, whereas 1 mg/kg increased ICSS thresholds and produced hypoactivity. Both effects were reversed by pre-treatment with SR141716A, indicating the involvement of CB(1) receptors on these actions. Altogether, our results indicate that Δ(9)-THC can produce acute activating effects in locomotion that coincide with its reward-facilitating effects in the ICSS paradigm. The present findings provide further support that Δ(9)-THC induces behaviours typical of abuse and substantiate the notion that marijuana resembles other drugs of abuse.

Authors+Show Affiliations

Laboratory of Behavioral Neuroscience, Department of Psychology, School of Social Sciences, University of Crete, Crete, Greece.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23830148

Citation

Katsidoni, Vicky, et al. "Biphasic Effects of Δ9-tetrahydrocannabinol On Brain Stimulation Reward and Motor Activity." The International Journal of Neuropsychopharmacology, vol. 16, no. 10, 2013, pp. 2273-84.
Katsidoni V, Kastellakis A, Panagis G. Biphasic effects of Δ9-tetrahydrocannabinol on brain stimulation reward and motor activity. Int J Neuropsychopharmacol. 2013;16(10):2273-84.
Katsidoni, V., Kastellakis, A., & Panagis, G. (2013). Biphasic effects of Δ9-tetrahydrocannabinol on brain stimulation reward and motor activity. The International Journal of Neuropsychopharmacology, 16(10), 2273-84. https://doi.org/10.1017/S1461145713000709
Katsidoni V, Kastellakis A, Panagis G. Biphasic Effects of Δ9-tetrahydrocannabinol On Brain Stimulation Reward and Motor Activity. Int J Neuropsychopharmacol. 2013;16(10):2273-84. PubMed PMID: 23830148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biphasic effects of Δ9-tetrahydrocannabinol on brain stimulation reward and motor activity. AU - Katsidoni,Vicky, AU - Kastellakis,Andreas, AU - Panagis,George, Y1 - 2013/07/05/ PY - 2013/7/9/entrez PY - 2013/7/9/pubmed PY - 2014/7/2/medline SP - 2273 EP - 84 JF - The international journal of neuropsychopharmacology JO - Int J Neuropsychopharmacol VL - 16 IS - 10 N2 - Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the main psychoactive ingredient of marijuana, has led to equivocal results when tested with the intracranial self-stimulation (ICSS) procedure or the open-field test for motor activity, two behavioural models for evaluating the reward-facilitating and locomotor stimulating effects of drugs of abuse, respectively. Therefore, in the present study, the effects of high and low doses of Δ(9)-THC were compared in the ICSS procedure and the open-field test. Moreover, the involvement of CB(1) receptors in tentative Δ(9)-THC-induced effects was investigated by pre-treating the animals with the CB(1) receptor antagonist SR141716A (rimonabant). The results obtained show that low doses of Δ(9)-THC induce opposite effects from high doses of Δ(9)-THC. Specifically, 0.1 mg/kg Δ(9)-THC decreased ICSS thresholds and produced hyperactivity, whereas 1 mg/kg increased ICSS thresholds and produced hypoactivity. Both effects were reversed by pre-treatment with SR141716A, indicating the involvement of CB(1) receptors on these actions. Altogether, our results indicate that Δ(9)-THC can produce acute activating effects in locomotion that coincide with its reward-facilitating effects in the ICSS paradigm. The present findings provide further support that Δ(9)-THC induces behaviours typical of abuse and substantiate the notion that marijuana resembles other drugs of abuse. SN - 1469-5111 UR - https://www.unboundmedicine.com/medline/citation/23830148/Biphasic_effects_of_Δ9_tetrahydrocannabinol_on_brain_stimulation_reward_and_motor_activity_ L2 - https://academic.oup.com/ijnp/article-lookup/doi/10.1017/S1461145713000709 DB - PRIME DP - Unbound Medicine ER -