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Potential anti-inflammatory effect of Leea macrophylla Roxb. leaves: a wild edible plant.
Food Chem Toxicol. 2013 Sep; 59:514-20.FC

Abstract

Leea macrophylla (Leeaceae) is a wild edible plant with ethomedicinal importance as anti-inflammatory agent. However, no systematic studies on its anti-inflammatory activity and mechanisms have been reported. Present study was undertaken to evaluate anti-inflammatory activity of methanol extract of L. macrophylla leaves. Phytochemical investigation revealed presence of sterols, triterpenoids and ascorbic acid in extract. Methanol extract inhibited lipopolysaccharide stimulated production of inflammatory mediators viz. prostaglandin E2, tumor necrotic factor-α, interleukin-6 and interleukin-1β in vitro in mouse peritoneal macrophages. Additionally, the in vivo anti-inflammatory activity of this extract was evaluated by using carrageenan induced paw edema and cotton pellet granuloma assays in experimental rats. Oral administration of extract (100 and 200 mg/kg) exhibited dose dependant inhibition of carrageenan induced inflammation (p<0.05) and the reduction of the granuloma tissue formation (p<0.05-0.01). The extract (100 and 200 mg/kg, orally) exhibited significant central and peripheral analgesic activity in hot-plate test (p<0.01) and acetic acid induced writhing test (p<0.05-0.01) respectively in experimental mice. Treatment with extract (100 and 200 mg/kg, orally) significantly reduced the yeast provoked elevated body temperature (p<0.05-0.01) in experimental rats. These results confirmed the traditional anti-inflammatory indication of L. macrophylla leaves.

Authors+Show Affiliations

Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. s.dewanjeer@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23831308

Citation

Dewanjee, Saikat, et al. "Potential Anti-inflammatory Effect of Leea Macrophylla Roxb. Leaves: a Wild Edible Plant." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 59, 2013, pp. 514-20.
Dewanjee S, Dua TK, Sahu R. Potential anti-inflammatory effect of Leea macrophylla Roxb. leaves: a wild edible plant. Food Chem Toxicol. 2013;59:514-20.
Dewanjee, S., Dua, T. K., & Sahu, R. (2013). Potential anti-inflammatory effect of Leea macrophylla Roxb. leaves: a wild edible plant. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 59, 514-20. https://doi.org/10.1016/j.fct.2013.06.038
Dewanjee S, Dua TK, Sahu R. Potential Anti-inflammatory Effect of Leea Macrophylla Roxb. Leaves: a Wild Edible Plant. Food Chem Toxicol. 2013;59:514-20. PubMed PMID: 23831308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential anti-inflammatory effect of Leea macrophylla Roxb. leaves: a wild edible plant. AU - Dewanjee,Saikat, AU - Dua,Tarun K, AU - Sahu,Ranabir, Y1 - 2013/07/02/ PY - 2013/05/01/received PY - 2013/06/04/revised PY - 2013/06/19/accepted PY - 2013/7/9/entrez PY - 2013/7/9/pubmed PY - 2014/3/29/medline KW - Analgesic KW - Anti-inflammatory KW - Leea macrophylla KW - Methanol extract SP - 514 EP - 20 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 59 N2 - Leea macrophylla (Leeaceae) is a wild edible plant with ethomedicinal importance as anti-inflammatory agent. However, no systematic studies on its anti-inflammatory activity and mechanisms have been reported. Present study was undertaken to evaluate anti-inflammatory activity of methanol extract of L. macrophylla leaves. Phytochemical investigation revealed presence of sterols, triterpenoids and ascorbic acid in extract. Methanol extract inhibited lipopolysaccharide stimulated production of inflammatory mediators viz. prostaglandin E2, tumor necrotic factor-α, interleukin-6 and interleukin-1β in vitro in mouse peritoneal macrophages. Additionally, the in vivo anti-inflammatory activity of this extract was evaluated by using carrageenan induced paw edema and cotton pellet granuloma assays in experimental rats. Oral administration of extract (100 and 200 mg/kg) exhibited dose dependant inhibition of carrageenan induced inflammation (p<0.05) and the reduction of the granuloma tissue formation (p<0.05-0.01). The extract (100 and 200 mg/kg, orally) exhibited significant central and peripheral analgesic activity in hot-plate test (p<0.01) and acetic acid induced writhing test (p<0.05-0.01) respectively in experimental mice. Treatment with extract (100 and 200 mg/kg, orally) significantly reduced the yeast provoked elevated body temperature (p<0.05-0.01) in experimental rats. These results confirmed the traditional anti-inflammatory indication of L. macrophylla leaves. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/23831308/Potential_anti_inflammatory_effect_of_Leea_macrophylla_Roxb__leaves:_a_wild_edible_plant_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(13)00417-1 DB - PRIME DP - Unbound Medicine ER -