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Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine.
Behav Brain Res 2013; 253:68-77BB

Abstract

Studies have suggested that cognitive deficits can precede motor alterations in Parkinson's disease (PD). However, in general, classic animal models are based on severe motor impairment after one single administration of neurotoxins, and thereby do not express the progressive nature of the pathology. A previous study showed that the repeated administration with a low dose (0.1mg/kg) of the monoamine depleting agent reserpine induces a gradual appearance of motor signs of pharmacological parkinsonism in rats. Here, we showed this repeated treatment with reserpine induced a memory impairment (evaluated by the novel object recognition task) before the gradual appearance of the motor signs. Additionally, these alterations were accompanied by decreased tyrosine hydroxylase (TH) striatal levels and reduced number of TH+ cells in substantia nigra pars compacta (SNpc). After 30 days without treatment, reserpine-treated animals showed normal levels of striatal TH, partial recovery of TH+ cells in SNpc, recovery of motor function, but not reversal of the memory impairment. Furthermore, the motor alterations were statistically correlated with decreased TH levels (GD, CA1, PFC and DS) and number of TH+ cells (SNpc and VTA) in the brain. Thus, we extended previous results showing that the gradual appearance of motor impairment induced by repeated treatment with a low dose of reserpine is preceded by short-term memory impairment, as well as accompanied by neurochemical alterations compatible with the pathology of PD.

Authors+Show Affiliations

Laboratory of Memory Studies, Physiology Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23831411

Citation

Santos, José R., et al. "Cognitive, Motor and Tyrosine Hydroxylase Temporal Impairment in a Model of Parkinsonism Induced By Reserpine." Behavioural Brain Research, vol. 253, 2013, pp. 68-77.
Santos JR, Cunha JA, Dierschnabel AL, et al. Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine. Behav Brain Res. 2013;253:68-77.
Santos, J. R., Cunha, J. A., Dierschnabel, A. L., Campêlo, C. L., Leão, A. H., Silva, A. F., ... Silva, R. H. (2013). Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine. Behavioural Brain Research, 253, pp. 68-77. doi:10.1016/j.bbr.2013.06.031.
Santos JR, et al. Cognitive, Motor and Tyrosine Hydroxylase Temporal Impairment in a Model of Parkinsonism Induced By Reserpine. Behav Brain Res. 2013 Sep 15;253:68-77. PubMed PMID: 23831411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine. AU - Santos,José R, AU - Cunha,João A S, AU - Dierschnabel,Aline L, AU - Campêlo,Clarissa L C, AU - Leão,Anderson H F F, AU - Silva,Anatildes F, AU - Engelberth,Rovena C G J, AU - Izídio,Geison S, AU - Cavalcante,Jeferson S, AU - Abílio,Vanessa C, AU - Ribeiro,Alessandra M, AU - Silva,Regina H, Y1 - 2013/07/03/ PY - 2012/12/05/received PY - 2013/06/21/revised PY - 2013/06/26/accepted PY - 2013/7/9/entrez PY - 2013/7/9/pubmed PY - 2014/3/19/medline KW - Animal model KW - Memory KW - Movement disorders KW - Parkinson's disease KW - Reserpine SP - 68 EP - 77 JF - Behavioural brain research JO - Behav. Brain Res. VL - 253 N2 - Studies have suggested that cognitive deficits can precede motor alterations in Parkinson's disease (PD). However, in general, classic animal models are based on severe motor impairment after one single administration of neurotoxins, and thereby do not express the progressive nature of the pathology. A previous study showed that the repeated administration with a low dose (0.1mg/kg) of the monoamine depleting agent reserpine induces a gradual appearance of motor signs of pharmacological parkinsonism in rats. Here, we showed this repeated treatment with reserpine induced a memory impairment (evaluated by the novel object recognition task) before the gradual appearance of the motor signs. Additionally, these alterations were accompanied by decreased tyrosine hydroxylase (TH) striatal levels and reduced number of TH+ cells in substantia nigra pars compacta (SNpc). After 30 days without treatment, reserpine-treated animals showed normal levels of striatal TH, partial recovery of TH+ cells in SNpc, recovery of motor function, but not reversal of the memory impairment. Furthermore, the motor alterations were statistically correlated with decreased TH levels (GD, CA1, PFC and DS) and number of TH+ cells (SNpc and VTA) in the brain. Thus, we extended previous results showing that the gradual appearance of motor impairment induced by repeated treatment with a low dose of reserpine is preceded by short-term memory impairment, as well as accompanied by neurochemical alterations compatible with the pathology of PD. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/23831411/Cognitive_motor_and_tyrosine_hydroxylase_temporal_impairment_in_a_model_of_parkinsonism_induced_by_reserpine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(13)00394-X DB - PRIME DP - Unbound Medicine ER -