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Burden and health-related quality of life among caregivers of Brazilian Parkinson's disease patients.
Parkinsonism Relat Disord. 2013 Nov; 19(11):943-8.PR

Abstract

PURPOSE

To analyze the main determinants of burden and health-related quality-of-life (HRQoL) in caregivers of Brazilian Parkinson's disease (PD) patients.

METHODS

Caregivers answered Hospital Anxiety and Depression Scale (HADS), Zarit caregiver burden interview (ZCBI) and EQ-5D, a generic measure of HRQoL. Patients were assessed with Hoehn and Yahr (H&Y) staging; Scales for Outcomes in Parkinson's disease (SCOPA) Motor, Cognition, Psychosocial and Sleep scales; Non-Motor Symptoms Scale; HADS; Clinical Impression of Severity Index; EQ-5D and Parkinson's Psychosis Rating Scale.

RESULTS

50 Caregiver-patient dyads were assessed. Caregivers were significantly younger (55.7 vs. 65.4 years), p < 0.0001. Eighty-eight per cent of caregivers were females, and 78% were spouses. The proportion of caregivers who scored ≥11 points in the HADS-anxiety or HADS-depression subscales was 12% and 14% respectively. ZCBI mean score was 20.2 (SD 12.8), and significantly worsened as severity of disease, based on H&Y, increased (H&Y 1-2: 16.4, H&Y 3-5: 24.6; p = 0.02). Caregiver's EQ-5D Index and visual analog scale mean scores were 0.7 (SD: 0.26) and 76.3 (SD: 16.2) respectively. Weak to moderate association (r = -0.27 to -0.39) between EQ-5D Index and ZBCI mean scores was observed in caregivers. Patient outcomes (sleep disorders and behavioral-psychotic symptoms) and caregiver outcomes (mood, time of caregiving) were independent predictors of caregiver burden (adjusted R(2) = 0.55; p < 0.0001) in the multivariate regression analysis. Caregiver's mood status was a significant determinant of caregiver's HRQoL, as measured by the EQ-5D Index (adjusted R(2) = 0.28; p = 0.006).

CONCLUSIONS

Patients' psychiatric and sleep disorders and caregiver's mood significantly influenced burden and HRQoL in Brazilian PD caregivers.

Authors+Show Affiliations

Medicine and Health Sciences Faculty, Universitat Internacional de Catalunya (UIC), Barcelona, Spain. Electronic address: fjcarod-artal@hotmail.com.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

23831481

Citation

Carod-Artal, Francisco Javier, et al. "Burden and Health-related Quality of Life Among Caregivers of Brazilian Parkinson's Disease Patients." Parkinsonism & Related Disorders, vol. 19, no. 11, 2013, pp. 943-8.
Carod-Artal FJ, Mesquita HM, Ziomkowski S, et al. Burden and health-related quality of life among caregivers of Brazilian Parkinson's disease patients. Parkinsonism Relat Disord. 2013;19(11):943-8.
Carod-Artal, F. J., Mesquita, H. M., Ziomkowski, S., & Martinez-Martin, P. (2013). Burden and health-related quality of life among caregivers of Brazilian Parkinson's disease patients. Parkinsonism & Related Disorders, 19(11), 943-8. https://doi.org/10.1016/j.parkreldis.2013.06.005
Carod-Artal FJ, et al. Burden and Health-related Quality of Life Among Caregivers of Brazilian Parkinson's Disease Patients. Parkinsonism Relat Disord. 2013;19(11):943-8. PubMed PMID: 23831481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Burden and health-related quality of life among caregivers of Brazilian Parkinson's disease patients. AU - Carod-Artal,Francisco Javier, AU - Mesquita,Hudson Mourão, AU - Ziomkowski,Sofia, AU - Martinez-Martin,Pablo, Y1 - 2013/07/04/ PY - 2013/1/18/received PY - 2013/5/12/revised PY - 2013/6/10/accepted PY - 2013/7/9/entrez PY - 2013/7/9/pubmed PY - 2014/6/28/medline KW - Burden KW - Caregivers KW - Depression KW - Health status KW - Parkinson's disease KW - Quality of life SP - 943 EP - 8 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 19 IS - 11 N2 - PURPOSE: To analyze the main determinants of burden and health-related quality-of-life (HRQoL) in caregivers of Brazilian Parkinson's disease (PD) patients. METHODS: Caregivers answered Hospital Anxiety and Depression Scale (HADS), Zarit caregiver burden interview (ZCBI) and EQ-5D, a generic measure of HRQoL. Patients were assessed with Hoehn and Yahr (H&Y) staging; Scales for Outcomes in Parkinson's disease (SCOPA) Motor, Cognition, Psychosocial and Sleep scales; Non-Motor Symptoms Scale; HADS; Clinical Impression of Severity Index; EQ-5D and Parkinson's Psychosis Rating Scale. RESULTS: 50 Caregiver-patient dyads were assessed. Caregivers were significantly younger (55.7 vs. 65.4 years), p < 0.0001. Eighty-eight per cent of caregivers were females, and 78% were spouses. The proportion of caregivers who scored ≥11 points in the HADS-anxiety or HADS-depression subscales was 12% and 14% respectively. ZCBI mean score was 20.2 (SD 12.8), and significantly worsened as severity of disease, based on H&Y, increased (H&Y 1-2: 16.4, H&Y 3-5: 24.6; p = 0.02). Caregiver's EQ-5D Index and visual analog scale mean scores were 0.7 (SD: 0.26) and 76.3 (SD: 16.2) respectively. Weak to moderate association (r = -0.27 to -0.39) between EQ-5D Index and ZBCI mean scores was observed in caregivers. Patient outcomes (sleep disorders and behavioral-psychotic symptoms) and caregiver outcomes (mood, time of caregiving) were independent predictors of caregiver burden (adjusted R(2) = 0.55; p < 0.0001) in the multivariate regression analysis. Caregiver's mood status was a significant determinant of caregiver's HRQoL, as measured by the EQ-5D Index (adjusted R(2) = 0.28; p = 0.006). CONCLUSIONS: Patients' psychiatric and sleep disorders and caregiver's mood significantly influenced burden and HRQoL in Brazilian PD caregivers. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/23831481/Burden_and_health_related_quality_of_life_among_caregivers_of_Brazilian_Parkinson's_disease_patients_ DB - PRIME DP - Unbound Medicine ER -